Zobrazeno 1 - 10
of 6 548
pro vyhledávání: '"Disease Modeling"'
Autor:
Andrew Omame, Qing Han, Sarafa A. Iyaniwura, Adeniyi Ebenezer, Nicola L. Bragazzi, Xiaoying Wang, Jude D. Kong, Woldegebriel A. Woldegerima
Publikováno v:
Infectious Disease Modelling, Vol 9, Iss 4, Pp 1117-1137 (2024)
The recent mpox outbreak (in 2022–2023) has different clinical and epidemiological features compared with previous outbreaks of the disease. During this outbreak, sexual contact was believed to be the primary transmission route of the disease. In a
Externí odkaz:
https://doaj.org/article/0af8961613b343deafe8ac46a6601bdf
Publikováno v:
AIMS Mathematics, Vol 9, Iss 11, Pp 32962-32999 (2024)
This paper provided a review of the Lurie problem and its applications to control as well as modeling problems in the medical and biological fields, highlighting its connection with robust control theory, more specifically the works of Doyle, Skogest
Externí odkaz:
https://doaj.org/article/4131a9ee1c9c4f2eb050e946220308c3
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Neurodegenerative diseases (NDDs) present significant challenges due to limited treatment options, ethical concerns surrounding traditional animal models, and the time-consuming and costly process of using human-induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/8d6fcf1c87ad4891982aede737fb459d
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Background Three common isoforms of the apolipoprotein E (APOE) gene - APOE2, APOE3, and APOE4 - hold varying significance in Alzheimer’s Disease (AD) risk. The APOE4 allele is the strongest known genetic risk factor for late-onset Alzheim
Externí odkaz:
https://doaj.org/article/7a403e4b781f42eca1801c88e8400139
Autor:
Habibou Fofana, Ali Sié, Moussa Ouédraogo, Moubassira Kagoné, Chinyere O. Mbachu, Obinna E. Onwujekwe, Latha Chilgod, Maulik Chokshi, Arun B. Nair, Tushar Mokashi, Abeba Taddese, Peter Muriuki, Apoorva Handigol, Leah Ewald
Publikováno v:
Gates Open Research, Vol 7 (2024)
Background This study sought to document and understand facilitators and barriers to producing, translating, and using modeled evidence in decision-making in Burkina Faso, Nigeria, India, and Kenya. We explored researcher-decision-maker engagement me
Externí odkaz:
https://doaj.org/article/f1c414d4dab142b68dfbc7df9e4af3c9
Publikováno v:
Bioactive Materials, Vol 43, Iss , Pp 195-224 (2025)
The epithelium is one of the important tissues in the body as it plays a crucial barrier role serving as a gateway into and out of the body. Most organs in the body contain an epithelial tissue component, where the tightly connected, organ-specific e
Externí odkaz:
https://doaj.org/article/7626a8e8837d4e0fb320a3cded852d9a
Publikováno v:
Precision and Future Medicine, Vol 8, Iss 3, Pp 65-73 (2024)
Understanding the genetic basis and pathomechanisms underlying dementia arising from single-gene mutations is crucial to expand our knowledge in the field of dementia research. In this review, we comprehensively summarize the results of existing rese
Externí odkaz:
https://doaj.org/article/c08a397c1cc341138594419aeef7b6af
Autor:
Veronika Juráková, Balázs Széky, Martina Zapletalová, Anita Fehér, Melinda Zana, Shashank Pandey, Radek Kučera, Omar Šerý, Jiří Hudeček, András Dinnyés, Jan Lochman
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract Background Astrocytes have recently gained attention as key players in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease. Numerous differentiation protocols have been developed to study human astrocytes in vitro.
Externí odkaz:
https://doaj.org/article/a22ceaa92f594db0b4bcadad8bf67b48
Autor:
Thomas Hutschalik, Ozan Özgül, Marilù Casini, Brigitta Szabó, Rémi Peyronnet, Óscar Bártulos, Mariana Argenziano, Ulrich Schotten, Elena Matsa
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Atrial fibrillation has an estimated prevalence of 1.5–2%, making it the most common cardiac arrhythmia. The processes that cause and sustain the disease are still not completely understood. An association between atrial fibrill
Externí odkaz:
https://doaj.org/article/62230f7377c342b9b213ccfb407b8704
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Multiple sclerosis (MS), a debilitating autoimmune disorder targeting the central nervous system (CNS), is marked by relentless demyelination and inflammation. Clinically, it presents in three distinct forms: relapsing–remitting MS (RRMS), primary
Externí odkaz:
https://doaj.org/article/98f7cc3806334440adc14f61a3d80635