Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Discrete optimized protein energy"'
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss, Pp 133-145 (2021)
Current Research in Structural Biology
Current Research in Structural Biology
The evolution of homologous and functionally equivalent multiprotein assemblies is intriguing considering sequence divergence of constituent proteins. Here, we studied the implications of protein sequence divergence on the structure, dynamics and fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efeea81e990e5e7c7957d60f1e6c8c1
http://www.sciencedirect.com/science/article/pii/S2665928X2100009X
http://www.sciencedirect.com/science/article/pii/S2665928X2100009X
Autor:
Mohammad Faranoush, Hamzeh Rahimi, Hasan Mirzahoseini, Seyed Mehdi Sajjadi, Gholamreza Toogeh, Saeed Mohammadi
Publikováno v:
Research in Pharmaceutical Sciences, Vol 12, Iss 1, Pp 60-66 (2017)
Research in Pharmaceutical Sciences
Research in Pharmaceutical Sciences
Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae005b05837fa5f4ec1ce5ca4821b02
http://www.rpsjournal.net/article.asp?issn=1735-5362
http://www.rpsjournal.net/article.asp?issn=1735-5362
Autor:
Gurung, Arun Bahadur
Publikováno v:
Gene Reports
The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment necessitates the identification of new antivirals. SARS-CoV-2 relies on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59819417a63124b98e4c37f0b5efbc6c
https://doi.org/10.1016/j.genrep.2020.100860
https://doi.org/10.1016/j.genrep.2020.100860
Autor:
Juan Francisco Morales, Agustina María Pino Martínez, María Daniela Ruiz, Lucas Nicolás Alberca, Pablo Hernán Palestro, María Laura Sbaraglini, Catalina D. Alba Soto, Roque Carlos Dietrich, Alan Talevi, Laura Virginia Fraccaroli, Carolina Carrillo, Cristian Gabriel Miranda
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Cellular and Infection Microbiology
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Cellular and Infection Microbiology
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Chagas disease is a neglected tropical disease endemic to Latin America, though migratory movements have recently spread it to other regions. Here, we have applied a cascade virtual screening campaign combining ligand- and structure-based methods. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ca34a9bef8119aedd5953fcd274f49
https://doi.org/10.3389/fcimb.2018.00173
https://doi.org/10.3389/fcimb.2018.00173
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Journal of Computational Chemistry. 33:1927-1935
A homology model builder using simple restraining potentials based on spline-interpolated quadratic functions is developed and interfaced with CHARMM package. The continuity and stability of the potential function were validated, and the parameters w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9d80ad59376dbb48dda0d5384d819e
https://doi.org/10.1002/jcc.23024
https://doi.org/10.1002/jcc.23024
Autor:
Yaoqi Zhou, Yuedong Yang
Publikováno v:
Protein Science. 17:1212-1219
One of the common methods for assessing energy functions of proteins is selection of native or near-native structures from decoys. This is an efficient but indirect test of the energy functions because decoy structures are typically generated either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f02b3cff0a939ac87f70b26f019e2a1
https://doi.org/10.1110/ps.033480.107
https://doi.org/10.1110/ps.033480.107
Autor:
Daisuke Kihara, Hao Chen
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 71:1255-1274
The error in protein tertiary structure prediction is unavoidable, but it is not explicitly shown in most of the current prediction algorithms. Estimated error of a predicted structure is crucial information for experimental biologists to use the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5ec21593551e3827c5953f2ac6f53e
https://doi.org/10.1002/prot.21819
https://doi.org/10.1002/prot.21819
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 69:394-408
We have revisited the protein coarse-grained optimized potential for efficient structure prediction (OPEP). The training and validation sets consist of 13 and 16 protein targets. Because optimization depends on details of how the ensemble of decoys i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a704e6da91e00ec040efbe99a81558
https://doi.org/10.1002/prot.21505
https://doi.org/10.1002/prot.21505
Publikováno v:
Protein Science. 16:2123-2139
We developed a series of statistical potentials to recognize the native protein from decoys, particularly when using only a reduced representation in which each side chain is treated as a single C(beta) atom. Beginning with a highly successful all-at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a56e7b2ff028813682d2975e2c7cc4
https://doi.org/10.1110/ps.072939707
https://doi.org/10.1110/ps.072939707