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COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models.

Autor: Maisonnasse P; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Aldon Y; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Marc A; Université de Paris, INSERM, IAME, F-75018 Paris, France., Marlin R; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Dereuddre-Bosquet N; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Kuzmina NA; Department of Pathology, University of Texas Medical Branch at Galveston, Texas, USA.; Galveston National Laboratory, Texas, USA., Freyn AW; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA., Snitselaar JL; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Gonçalves A; Université de Paris, INSERM, IAME, F-75018 Paris, France., Caniels TG; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Burger JA; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Poniman M; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Chesnais V; Life and Soft, 92350 Le Plessis-Robinson, France., Diry S; Life and Soft, 92350 Le Plessis-Robinson, France., Iershov A; Life and Soft, 92350 Le Plessis-Robinson, France., Ronk AJ; Department of Pathology, University of Texas Medical Branch at Galveston, Texas, USA.; Galveston National Laboratory, Texas, USA., Jangra S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA., Rathnasinghe R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York (NY), USA., Brouwer P; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Bijl T; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., van Schooten J; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Brinkkemper M; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Liu H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Yuan M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Mire CE; Galveston National Laboratory, Texas, USA.; Department of Microbiology, University of Texas Medical Branch at Galveston, Texas, USA., van Breemen MJ; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Contreras V; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Naninck T; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Lemaître J; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Kahlaoui N; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Relouzat F; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Chapon C; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., Ho Tsong Fang R; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France., McDanal C; Duke Human Vaccine Institute & Department of Surgery, Durham, NC 27710, USA., Osei-Twum M; Nexelis, Laval, Québec, Canada., St-Amant N; Nexelis, Laval, Québec, Canada., Gagnon L; Nexelis, Laval, Québec, Canada., Montefiori DC; Duke Human Vaccine Institute & Department of Surgery, Durham, NC 27710, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Ginoux E; Life and Soft, 92350 Le Plessis-Robinson, France., de Bree GJ; Internal Medicine of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York (NY), USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York (NY), USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York (NY), USA., Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York (NY), USA., Coughlan L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York (NY), USA.; University of Maryland School of Medicine, Department of Microbiology and Immunology and Center for Vaccine Development and Global Health (CVD), 685 W. Baltimore Street, HSF1, Office #380E, Baltimore, MD 21201., Bukreyev A; Department of Pathology, University of Texas Medical Branch at Galveston, Texas, USA.; Galveston National Laboratory, Texas, USA.; Department of Microbiology, University of Texas Medical Branch at Galveston, Texas, USA., van der Werf S; Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, CNRS UMR 3569, Université de Paris, Paris, France.; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France., Guedj J; Université de Paris, INSERM, IAME, F-75018 Paris, France., Sanders RW; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands.; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA., van Gils MJ; Departments of Medical Microbiology of the Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105 AZ, Amsterdam, The Netherlands., Le Grand R; Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

Publikováno v: Research square [Res Sq] 2021 Feb 15. Date of Electronic Publication: 2021 Feb 15.