Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dirke Imig"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007812 (2020)
Apoptotic cell death can be initiated through the extrinsic and intrinsic signaling pathways. While cell cycle progression promotes the responsiveness to intrinsic apoptosis induced by genotoxic stress or spindle poisons, this has not yet been studie
Externí odkaz:
https://doaj.org/article/df01bb7e1d354c4297daaf5098cedcc8
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198203 (2018)
Dysregulation of the mitochondrial signaling pathway of apoptosis induction represents a major hurdle in tumor therapy. The objective of the presented work was to investigate the role of the intrinsic (mitochondrial) apoptotic pathway in the non-smal
Externí odkaz:
https://doaj.org/article/9e232127ea1d4ef3932132940bc1d1b5
Cell cycle progression and transmitotic apoptosis resistance promote escape from extrinsic apoptosis
Autor:
Peter Scheurich, Frank Allgöwer, Daniela Stöhr, Markus Rehm, Isabel Heinrich, Karsten Kuritz, Nadine Pollak, Aline Lindner, Lorena Decker, Jacques S Fritze, Jannis Stadager, Dirke Imig, Stephan A. Eisler
Publikováno v:
Journal of Cell Science. 134
Extrinsic apoptosis relies on TNF-family receptor activation by immune cells or receptor-activating drugs. Here, we monitored cell cycle progression at a resolution of minutes to relate apoptosis kinetics and cell-to-cell heterogeneities in death dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d58a0d8bb5223055bc6ed248d9a2252
https://doi.org/10.1242/jcs.258966
https://doi.org/10.1242/jcs.258966
Publikováno v:
IFAC-PapersOnLine. 52:207-212
The endogenous ligand TRAIL induces cell death and constitutes a promising molecule for cancer therapies. However, reasons for TRAIL-insensitivity of various tumor-based cancer cell lines remain unclear. In this paper, we introduce a complex individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f9c86e489d2b21a56fda944eff7817e
https://doi.org/10.1016/j.ifacol.2019.12.259
https://doi.org/10.1016/j.ifacol.2019.12.259
Autor:
Nadine Pollak, Jacques S Fritze, Peter Scheurich, Karsten Kuritz, Heinrich I, Daniela Stöhr, Stadager J, Frank Allgöwer, Morrison (Rehm) M, Stephan A. Eisler, Lindner A, Dirke Imig
Extrinsic apoptosis relies on TNF-family receptor activation by immune cells or receptor-activating biologics. Here, we monitored cell cycle progression at minutes resolution to relate apoptosis kinetics and cell-to-cell heterogeneities in death deci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10c31887ebdd075fce8b628a8c953b7
https://doi.org/10.1101/2021.02.26.433034
https://doi.org/10.1101/2021.02.26.433034
Publikováno v:
IFAC-PapersOnLine. 51:90-93
Drug-induced cell death on the one hand, and dynamics of the cell cycle on the other hand, represent two well-investigated biological principles. As the cell death machinery is highly regulated and depends on a large number of signaling proteins, a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd23fc305bf367f6b32da76dba56489
https://doi.org/10.1016/j.ifacol.2018.09.028
https://doi.org/10.1016/j.ifacol.2018.09.028
Publikováno v:
IFAC-PapersOnLine. 51:44-47
We investigate the problem of synchronizing a population of cellular oscillators in their cell cycle. Restrictions on the observability and controllability of the population imposed by the nature of cell biology give rise to an ensemble control probl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8523a0633a23068f6f1e19a3d482fe9
https://doi.org/10.1016/j.ifacol.2018.09.034
https://doi.org/10.1016/j.ifacol.2018.09.034
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007812 (2020)
PLoS Computational Biology
PLoS Computational Biology
Apoptotic cell death can be initiated through the extrinsic and intrinsic signaling pathways. While cell cycle progression promotes the responsiveness to intrinsic apoptosis induced by genotoxic stress or spindle poisons, this has not yet been studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ba88e3645a069f766b74d32753e0bf
https://doi.org/10.1371/journal.pcbi.1007812
https://doi.org/10.1371/journal.pcbi.1007812
Autor:
Markus Rehm, Frank A. Lincoln, Roland E. Kontermann, Frank Allgöwer, Brona M. Murphy, Dirke Imig, Janis Noonan, Viktorija Juric, Chiara Boccellato
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 11, Pp 1-14 (2018)
Cell Death and Disease, Vol 9, Iss 11, Pp 1-14 (2018)
Due to the lack of effective treatments for glioblastoma (GBM), we here studied the responsiveness of GBM cell lines to the combination of death ligand, TRAIL and the IAP antagonist, TL32711 (Birinapant). Responses were highly heterogeneous, with syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3f79eba16d11aa3bb872216149e53c
ispartof: Journal of Coupled Systems and Multiscale vol:3 issue:2 pages:143-155 status: published
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b40addcb796b3fa8ab5ec540fc4933
https://lirias.kuleuven.be/handle/123456789/561541
https://lirias.kuleuven.be/handle/123456789/561541