Sixteen diverse laboratory mouse reference genomes define strain specific haplotypes and novel functional loci

Autor: Leo Goodstadt, Mark Gerstein, Mark G. Thomas, Jingtao Lilue, Glen Threadgold, Fengtang Yang, Sarah Pelan, Jane E. Loveland, Kim Wong, Fabio C. P. Navarro, Jennifer Harrow, Ruth Bennett, Richard Durbin, Dent Earl, Monica Abrudan, Mario Stanke, David J. Adams, Adam Frankish, Son Pham, Anne Czechanski, Charles A. Steward, Jonathan Flint, Beiyuan Fu, Ian T. Fiddes, William Chow, Duncan T. Odom, Marcela K. Sjoberg-Herrera, Naomi Park, Paul Flicek, Anne C. Ferguson-Smith, James G. R. Gilbert, Lelliott C, Mikhail Kolmogorov, Mark Diekhans, Laura G. Reinholdt, Stefanie Nachtweide, Cristina Sisu, Thomas M. Keane, James Torrance, Richard Mott, Benedict Paten, Petr Danecek, Dirk-Dominik Dolle, Paul R. Muir, Ximena Ibarra-Soria, Stephan C. Collins, Binnaz Yalcin, Darren W. Logan, Lars Romoth, Matthew Dunn, Lesley Shirley, Kerstin Howe, David Thybert, Michael A. Quail, Clayton E. Mathews, Jonathan Wood, Anthony G. Doran, Joanna Collins, Joel Armstrong

Publikováno v: Nature Genetics
Nature Genetics, Nature Publishing Group, 2018, 50 (11), pp.1574-1583. ⟨10.1038/s41588-018-0223-8⟩
Nature Genetics, 2018, 50 (11), pp.1574-1583. ⟨10.1038/s41588-018-0223-8⟩
Nature genetics

We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains and find extensive strain-specific haplotype variation. We identify and characterize 2,567 regions on the current mouse reference genome exhibiting the grea

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http://bura.brunel.ac.uk/handle/2438/16930