Výsledky vyhledávání - "Dirk van Papendorp"

Akademický článek

Ultrastructural changes of erythrocytes in whole blood after exposure to prospective in silico-designed anticancer agents: a qualitative case study

Autor: Lisa Repsold, Thandi Mqoco, Elize Wolmarans, Sandra Nkandeu, Joji Theron, Tomek Piorkowski, Peet du Toit, Dirk van Papendorp, Annie Margaretha Joubert

Publikováno v: Biological Research, Vol 47, Iss 0, Pp 1-7 (2014)

BACKGROUND: Novel, in silico-designed anticancer compounds were synthesized in our laboratory namely, 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) and 2-ethyl-3-O-sulphamoyl-estra-1,3,5(10)16-tetraene (ESE-16). These compounds

Externí odkaz: https://doaj.org/article/2a43e687de674add8279c3c7fc6d2e1d

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hFOB 1.19 osteoblast cells grown on a biomimetic biphasic nanoscaffold: An in vitro evaluation for possible bone tissue engineering

Autor: Ilse du Preez, Wim Richter, Dirk van Papendorp, Annie M. Joubert

Publikováno v: Biomedical Research. 29

Much research over the past five decades has focussed on the repair and replacement of bone. Recently, the research focus has shifted to nanotechnology since it provides a platform from which to alter and possibly improve materials’ properties. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd660e07c6d917a70e0cb4afc2f5fa35
https://doi.org/10.4066/biomedicalresearch.67-17-2720

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A Novel 2-Methoxyestradiol Analogue Is Responsible for Vesicle Disruption and Lysosome Aggregation in Breast Cancer Cells

Autor: Sandra D. Nkandeu, Anna Margaretha Joubert, Marianne J. Cronjé, Iman van den Bout, Dirk van Papendorp

Publikováno v: Pharmacology. 102(1-2)

Background: 2-Methoxyestradiol (2ME2) is an endogenous metabolite of 17-β-estradiol with anti-proliferative and anti-angiogenic properties. Due to 2ME2’s rapid metabolism and low oral bioavailability in in vivo settings, 2ME2 analogues have been d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a1fb77c6125f7acc8ec575b76b2225
https://pubmed.ncbi.nlm.nih.gov/29672318

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Adenosine Triphosphate (ATP) in the MCF-12A Epithelial Cell: Square Wave (150 Hz Pulsed Saw Tooth-like Waveform) versus AC Electric Stimulation in vitro

Autor: Mona-Liza Lottering, Annie M. Joubert, Dirk van Papendorp, Alida Koorts

Publikováno v: Biomedical Research. 23:249-253

Electrotherapy has been used for a variety of clinical conditions with varying results. In 1982 it was shown that a small DC current leads to an increase in ATP generation. ATP has been implicated as a peripheral mediator of pain. This study compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fce99de8a8654831185df28a74f643c3
https://doi.org/10.2220/biomedres.23.249

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Novel in silico-designed estradiol analogues are cytotoxic to a multidrug-resistant cell line at nanomolar concentrations

Autor: E.M. Nolte, Renaud Prudent, Peet J. Du Toit, Anne Elisabeth Theron, Annie M. Joubert, Rivak Punchoo, Sumari Marais, Yvette Hlophe, Dirk van Papendorp, Iman van den Bout, Laurence Lafanechère

Publikováno v: Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology, Springer Verlag, 2015, 75 (2), pp.431-437. ⟨10.1007/s00280-014-2653-z⟩

2-Methoxyestradiol (2ME) is a promising anti-cancer agent that disrupts the integrity and dynamics of the spindle network. In order to overcome the pharmacokinetic constraints of this compound, a panel of sulphamoylated estradiol analogues were in si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302dbaab893adcef1c739ea73950fc0f
https://pubmed.ncbi.nlm.nih.gov/25547405

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Ultrastructural changes of erythrocytes in whole blood after exposure to prospective in silico-designed anticancer agents: a qualitative case study

Autor: Tomek Piorkowski, Sandra D. Nkandeu, J. J. Theron, Peet J. Du Toit, T.V. Mqoco, Lisa Repsold, Elize Wolmarans, Annie M. Joubert, Dirk van Papendorp

Publikováno v: Biological Research v.47 2014
SciELO Chile
CONICYT Chile
instacron:CONICYT
Biological Research
Biological Research, Volume: 47, Pages: 1-7, Published: 2014
Biological Research, Vol 47, Iss 0, Pp 1-7 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ba7643b6bcec26f2ae7d21f02cbfd7
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100039

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The mammalian metabolite, 2-methoxyestradiol, affects p53 levels and apoptosis induction in transformed cells but not in normal cells

Autor: Dirk van Papendorp, Robert C. Habbersett, Yulin Shou, Bruce E. Lehnert, J.C. Seegers, Mona-Liza Lottering, Christina J.S. Grobler

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 62:253-267

The endogenous metabolite, 2-methoxyestradiol (2ME), is an inhibitor of tubulin polymerization and is therefore toxic to dividing fast-growing tumor cells. Transformed cells are not equally susceptible to the effects of 2ME. In this study the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c932f1004d2e345e16dd5d6ee68d9e
https://doi.org/10.1016/s0960-0760(97)00043-5

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In vitro effects of 2-methoxyestradiol on cell numbers, morphology, cell cycle progression, and apoptosis induction in oesophageal carcinoma cells

Autor: Dirk van Papendorp, Veneesha Thaver, Mona-Liza Lottering, Annie M. Joubert

Publikováno v: Cell biochemistry and function. 27(4)

The influence of 2-methoxyestradiol(2-ME) was investigated oncell numbers, morphology, cellcycleprogression,and apoptosis inductionin an oesophageal carcinoma cell line (WHCO3). Dose-dependent studies (1 � 10 � 9 M‐1 � 10 � 6 M) revealed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fa52914f0406047266cd82df1cdbc9
https://pubmed.ncbi.nlm.nih.gov/19343733

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