Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Dirk Ullmann"'
Autor:
Sonja Blasche, Mario Mörtl, Holger Steuber, Gabriella Siszler, Shahista Nisa, Frank Schwarz, Inna Lavrik, Thomas M A Gronewold, Klaus Maskos, Michael S Donnenberg, Dirk Ullmann, Peter Uetz, Manfred Kögl
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58937 (2013)
Enterohemorrhagic and enteropathogenic E. coli (EHEC and EPEC) can cause severe and potentially life-threatening infections. Their pathogenicity is mediated by at least 40 effector proteins which they inject into their host cells by a type-III secret
Externí odkaz:
https://doaj.org/article/73b654b40a5d425fa7021d4c8ba38cf5
Autor:
Steffen Grimm, Philipp Mracek, Janine Gastaldello, Dirk Ullmann, Adrian Kolodzik, Hamid R. Nasiri
Publikováno v:
MedChemComm. 8(6)
A highly miniaturized biochemical assay was set up to test a focused set of natural products against the enzymatic activity of protein tyrosine phosphatase 1B (PTP1B). The screen resulted in the identification of the natural product alkaloids, berber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7779e50bda5b9d65f1eaa4326e10eb
https://pubmed.ncbi.nlm.nih.gov/30108832
https://pubmed.ncbi.nlm.nih.gov/30108832
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(2)
Keap1 binds to the transcription factor Nrf2 and negatively modulates the expression of genes involved in cellular protection against oxidative stress. Small molecules have been discovered to inhibit the Nrf2:Keap1 interactions and act as antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abac31e8ce3fc2ef13b3494913dfe8f9
https://pubmed.ncbi.nlm.nih.gov/26653613
https://pubmed.ncbi.nlm.nih.gov/26653613
Publikováno v:
Marken und Medien ISBN: 9783658069339
Vom kleinen Privatsender mit geringer Reichweite in den 90er Jahren zum meistgehorten Lokalsender in Baden‐Wurttemberg. Anhand dieses Falls des Stuttgarter Senders DIE NEUE 107.7 wird der Weg vieler Sender mit steigender Professionalisierung beschr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd7391378c3a44b07e6ac842a7699f27
https://doi.org/10.1007/978-3-658-06934-6_30
https://doi.org/10.1007/978-3-658-06934-6_30
Reconstructing the Binding Site of Factor Xa in Trypsin Reveals Ligand-induced Structural Plasticity
Autor:
Sabine Reyda, Kathrin Rall, Gerhard Klebe, Hans Dieter Jakubke, Christian Sohn, Dirk Ullmann, Milton T. Stubbs
Publikováno v:
Journal of Molecular Biology. 325:963-977
In order to investigate issues of selectivity and specificity in protein-ligand interactions, we have undertaken the reconstruction of the binding pocket of human factor Xa in the structurally related rat trypsin by site-directed mutagenesis. Three s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8eac5fcf8474978f267c8c0ef7b6b9
https://doi.org/10.1016/s0022-2836(02)01337-2
https://doi.org/10.1016/s0022-2836(02)01337-2
Autor:
Dirk Ullmann, Nicolas Fay
Publikováno v:
Drug Discovery Today. 7:s181-s186
Recent advances in new analysis and prediction concepts in informatics, statistics and computational chemistry have drawn attention to mining the enormous flood of information generated from ultra-high-throughput screening (uHTS) and early drug disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c77752dfc0df379009c430fc73d2732
https://doi.org/10.1016/s1359-6446(02)02439-x
https://doi.org/10.1016/s1359-6446(02)02439-x
Autor:
Richard B. Hitchman, Shweta Singh, John J. Barker, Dirk Ullmann, Rahul B. Yadav, Nicolas Bertheleme, Stephanie Duclos
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:a429-a429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8389edeb8c2328361a624c9fea4f0bf8
https://doi.org/10.1107/s0108767317095812
https://doi.org/10.1107/s0108767317095812
Autor:
Dirk Ullmann, Julian Wölcke
Publikováno v:
Drug Discovery Today. 6:637-646
The transition from slow, manual, low-throughput screening to industrialized robotic ultra-high throughput screening (uHTS) in the past few years has made it possible to screen hundreds of thousands of chemical entities against a biological target in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96164e0edba46b8b3c2145547bd3dee0
https://doi.org/10.1016/s1359-6446(01)01807-4
https://doi.org/10.1016/s1359-6446(01)01807-4
Autor:
Sibylla Grahn, Dirk Ullmann, Sebastian H.J. Bauer, Torsten Kurth, Christian Elsner, Hans-Dieter Jakubke
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 8:193-200
Chemical modifications are a simple method to identify and modify functional determinants of enzymes. In the case of serine proteases, it is possible to induce characteristics which are advantageous for peptide synthesis. In this work, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2b6aabced0108e6b3dfcb8c13c7d657
https://doi.org/10.1016/s1381-1177(99)00057-0
https://doi.org/10.1016/s1381-1177(99)00057-0
Publikováno v:
Proceedings of the National Academy of Sciences. 96:13756-13761
A methodology, fluorescence-intensity distribution analysis, has been developed for confocal microscopy studies in which the fluorescence intensity of a sample with a heterogeneous brightness profile is monitored. An adjustable formula, modeling the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2495ab517cbcf24970617331fd0c1651
https://doi.org/10.1073/pnas.96.24.13756
https://doi.org/10.1073/pnas.96.24.13756