Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dirk Stenkamp"'
Autor:
Andreas Gollner, Markus Köster, Paul Nicklin, Thomas Trieselmann, Elliott Klein, Jaromir Vlach, Claudia Heine, Marc Grundl, Jürgen Ramharter, David Wyatt, Menorca Chaturvedi, Alessio Ciulli, Katharine C. Carter, Susanne Müller, Daniel Bischoff, Peter Ettmayer, Eric Haaksma, Jürgen Mack, Darryl McConnell, Dirk Stenkamp, Harald Weinstabl, Matthias Zentgraf, Clive R. Wood, Florian Montel
Publikováno v:
Nature reviews. Drug discovery. 21(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0532092410ea682f9e1120d72a6dd5c
https://pubmed.ncbi.nlm.nih.gov/35459938
https://pubmed.ncbi.nlm.nih.gov/35459938
Autor:
Thorsten Lehmann, Ralf Lotz, Thorsten Oost, Mueller Stephan Georg, Klaus Rudolf, Dirk Stenkamp, Armin Heckel, Ralph Budzinski, Jörg Kley, Gerd-Michael Maier, Gerald Juergen Roth, Leo Thomas, Martin Lenter, Kirsten Arndt, Michael Markert
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(16)
Although overweight and obesity are highly prevalent conditions, options to treat them are still very limited. As part of our search for safe and effective MCH-R1 antagonists for the treatment of obesity, two series of pyridones and pyridazinones wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91aeff56d7e815683ba2afe39561cfc7
https://pubmed.ncbi.nlm.nih.gov/26105194
https://pubmed.ncbi.nlm.nih.gov/26105194
Autor:
Gerd-Michael Maier, Thorsten Lehmann, Ralf Lotz, Jörg Kley, Martin Lenter, Michael Markert, Mueller Stephan Georg, Kirsten Arndt, Philipp Lustenberger, Klaus Rudolf, Thorsten Oost, Armin Heckel, Marcus Schindler, Gerald Juergen Roth, Dirk Stenkamp
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(16)
Despite recent approvals of anti-obesity drugs there is still a high therapeutic need for alternative options with higher efficacy in humans. As part of our MCH-R1 antagonist program for the treatment of obesity, a series of biphenylacetamide HTS hit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa1c429b6b312f875d5eaae07087eee
https://pubmed.ncbi.nlm.nih.gov/26112443
https://pubmed.ncbi.nlm.nih.gov/26112443
Autor:
Kirsten Arndt, Ralf Lotz, Klaus Rudolf, Thorsten Lehmann, Mueller Stephan Georg, Ralph Budzinski, Gerald Juergen Roth, Leo Thomas, Martin Lenter, Dirk Stenkamp, Armin Heckel, Thorsten Oost, Marcus Schindler, Jörg Kley
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(16)
Despite recent success there remains a high therapeutic need for the development of drugs targeting diseases associated with the metabolic syndrome. As part of our search for safe and effective MCH-R1 antagonists for the treatment of obesity, a serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f0c990c1fa596f4574b57cdd52b38e
https://pubmed.ncbi.nlm.nih.gov/26077492
https://pubmed.ncbi.nlm.nih.gov/26077492
Publikováno v:
Angewandte Chemie International Edition. 41:4573-4576
In the preceding communication,[1] the proposed synthesis plan identified the two principal pectenotoxin-4 subunits II and III (Figure 1). It was our intention to couple these fragments through the alkylation of the metalloenamine derived from hydraz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afdf026ea8399d783c6488913d263273
https://doi.org/10.1002/1521-3773(20021202)41:23<4573::aid-anie4573>3.0.co
https://doi.org/10.1002/1521-3773(20021202)41:23<4573::aid-anie4573>3.0.co
Publikováno v:
Angewandte Chemie International Edition. 41:4569-4573
The first members of the pectenotoxin family of marine natural products were isolated off the northeastern coast of Japan in 1985. Subsequently, ten members of this group have been identified.[1] The structural diversity within the pectenotoxins stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::135f1941fdbdb4d7d642c5658e8e80c5
https://doi.org/10.1002/1521-3773(20021202)41:23<4569::aid-anie4569>3.0.co
https://doi.org/10.1002/1521-3773(20021202)41:23<4569::aid-anie4569>3.0.co
Autor:
Heike A. Wieland, Henri Doods, Richard M. Söll, Annette G. Beck-Sickinger, Bärbel Lämmle, Dirk Stenkamp, Rudolf Hurnaus
Publikováno v:
European Journal of Biochemistry. 269:1128-1135
I-labelled orexin B from the recombinant orexin 1receptor stablyexpressedinChinesehamsterovarycells.Toexaminetheroleoftheshortenedorexin A23–33infeeding,its effects in mimicking or antagonizing the effects of orexinA were studied in rats after ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f34a200334eee25ddf035290726983a0
https://doi.org/10.1046/j.0014-2956.2001.02739.x
https://doi.org/10.1046/j.0014-2956.2001.02739.x
Publikováno v:
European Journal of Organic Chemistry. 1999:2929-2936
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785b9e4a1f40827a565de3bd0eca9ded
https://doi.org/10.1002/(sici)1099-0690(199911)1999:11<2929::aid-ejoc2929>3.0.co
https://doi.org/10.1002/(sici)1099-0690(199911)1999:11<2929::aid-ejoc2929>3.0.co
Publikováno v:
European Journal of Organic Chemistry. 1999:2915-2927
2,4-Disubstituted pentanes are molecules which adopt essentially only two conformations. Substituents have been varied in order to find those which lead to a strong preference of the conformer equilibrium. Studying 2-substituted 4-methylpentanes 3 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a24d1ed23e8704282e9b5524e13c7453
https://doi.org/10.1002/(sici)1099-0690(199911)1999:11<2915::aid-ejoc2915>3.0.co
https://doi.org/10.1002/(sici)1099-0690(199911)1999:11<2915::aid-ejoc2915>3.0.co
Autor:
Dirk Stenkamp, Reinhard W. Hoffmann
Publikováno v:
Tetrahedron. 55:7169-7176
The preference of (2R∗,4r∗,6S∗)-2,4,6-trichloroheptane ( 6 ) for populating the fully extended conformation mirrors the local conformational preferences of the 2,4-dichloropentane subunits. Likewise, the preference of (2R∗,4r∗,6S∗)-2,6-di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55657d9e788a044945250705de7a38ee
https://doi.org/10.1016/s0040-4020(99)00349-x
https://doi.org/10.1016/s0040-4020(99)00349-x