Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Dirk Schnappinger"'
Autor:
Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M. Bean, Inna V. Krieger, James C. Sacchettini, Sabine Ehrt, Courtney C. Aldrich, Dirk Schnappinger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Lipid biosynthesis in the pathogen Mycobacterium tuberculosis depends on biotin for posttranslational modification of key enzymes. However, the mycobacterial biotin synthetic pathway is not fully understood. Here, we show that rv1590, a gene
Externí odkaz:
https://doaj.org/article/3054e679f3564df091570ea68d735626
Autor:
Alexandra H. Miller, Frances Marks, Luming Chan, Helene Botella, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT Iron scavenging is required for full virulence of mycobacterial pathogens. During infection, the host immune response restricts mycobacterial access to iron, which is essential for bacterial respiration and DNA synthesis. The Mycobacterium t
Externí odkaz:
https://doaj.org/article/7d3f4a8023bb46768a12876ed6100852
Autor:
Sanjeevani Choudhery, Michael A DeJesus, Aarthi Srinivasan, Jeremy Rock, Dirk Schnappinger, Thomas R Ioerger
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1011408 (2024)
An important application of CRISPR interference (CRISPRi) technology is for identifying chemical-genetic interactions (CGIs). Discovery of genes that interact with exposure to antibiotics can yield insights to drug targets and mechanisms of action or
Externí odkaz:
https://doaj.org/article/22ac04704c36435b8f988a2b75a6c6b9
Autor:
Steven J. Grigsby, G.V.R. Krishna Prasad, Joshua B. Wallach, Ekansh Mittal, Fong-Fu Hsu, Dirk Schnappinger, Jennifer A. Philips
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114201- (2024)
Externí odkaz:
https://doaj.org/article/a32504df14934b809f3f49f6039f5fbf
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTType 2 NADH dehydrogenase (Ndh-2) is an oxidative phosphorylation enzyme discussed as a promising drug target in different pathogens, including Plasmodium falciparum and Mycobacterium tuberculosis (Mtb). To kill Mtb, Ndh-2 needs to be inactiv
Externí odkaz:
https://doaj.org/article/382a28c89f744f648c74ecee7b81358b
Autor:
Ritu Sharma, Travis E. Hartman, Tiago Beites, Jee-Hyun Kim, Hyungjin Eoh, Curtis A. Engelhart, Linnan Zhu, Daniel J. Wilson, Courtney C. Aldrich, Sabine Ehrt, Kyu Young Rhee, Dirk Schnappinger
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegen
Externí odkaz:
https://doaj.org/article/58351c1678134138a2c61182375d718c
Autor:
Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthet
Externí odkaz:
https://doaj.org/article/3aefb9dc25794e5b8cda7dfd998654ed
Autor:
Kaj M. Kreutzfeldt, Robert S. Jansen, Travis E. Hartman, Alexandre Gouzy, Ruojun Wang, Inna V. Krieger, Matthew D. Zimmerman, Martin Gengenbacher, Jansy P. Sarathy, Min Xie, Véronique Dartois, James C. Sacchettini, Kyu Y. Rhee, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Drug tolerance complicates the treatment of tuberculosis. Here, Kreutzfeldt et al. show that the protein CinA mediates drug tolerance in Mycobacterium tuberculosis by cleaving NAD-drug adducts, suggesting CinA as a potential target to shorten tubercu
Externí odkaz:
https://doaj.org/article/0ffbbce15de04ec482009cd19552b697
Autor:
Andrew I Wong, Tiago Beites, Kyle A Planck, Rachael A Fieweger, Kathryn A Eckartt, Shuqi Li, Nicholas C Poulton, Brian C VanderVen, Kyu Y Rhee, Dirk Schnappinger, Sabine Ehrt, Jeremy Rock
Publikováno v:
eLife, Vol 12 (2023)
Cyclic AMP (cAMP) is a ubiquitous second messenger that transduces signals from cellular receptors to downstream effectors. Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, devotes a considerable amount of coding capacity to p
Externí odkaz:
https://doaj.org/article/fe201b0981a543b4b8b62123b421ec24
Autor:
Tiago Beites, Robert S. Jansen, Ruojun Wang, Adrian Jinich, Kyu Y. Rhee, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The pathogen Mycobacterium tuberculosis depends on host fatty acids and cholesterol as carbon sources. Here, Beites et al. identify a protein complex that is essential for fatty acid and cholesterol utilization and thus for survival of M. tuberculosi
Externí odkaz:
https://doaj.org/article/56aca39f6d034a83b6674d2ac18e0572