Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Dirk Schmidt Arras"'
Autor:
Michela Luciano, Helene Sieberer, Peter W. Krenn, Hieu-Hoa Dang, Julia Vetter, Theresa Neuper, Diana Amend, Constantin Blöchl, Christian X. Weichenberger, Anna Eglseer, Michael S. Unger, Ancuela Andosch, Philip Steiner, Daniel Neureiter, Renate Bauer, Laura Hummer, Suzana Tesanovic, Stephanie Binder, Dominik P. Elmer, Helen Strandt, Susanne Schaller, Dirk Strunk, Lisa Pleyer, Richard Greil, Stephan Winkler, Tanja N. Hartmann, Dirk Schmidt-Arras, Christian G. Huber, Fritz Aberger, Jutta Horejs-Hoeck
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Acute myeloid leukemia (AML) is characterized by the abnormal proliferation of myeloid precursor cells and presents significant challenges in treatment due to its heterogeneity. Recently, the NLRP3 inflammasome has emerged as a po
Externí odkaz:
https://doaj.org/article/4d77e7ab0fdf4883bc818ffc7dd4f0d8
Autor:
Miryam Müller, Claire Saunders, Anke Senftleben, Johannes P. W. Heidbuechel, Birgit Halwachs, Julia Bolik, Nina Hedemann, Christian Röder, Dirk Bauerschlag, Stefan Rose-John, Dirk Schmidt-Arras
Publikováno v:
Cells, Vol 11, Iss 17, p 2683 (2022)
Ectodomain shedding is an irreversible process to regulate inter- and intracellular signaling. Members of the a disintegrin and metalloprotease (ADAM) family are major mediators of ectodomain shedding. ADAM17 is involved in the processing of multiple
Externí odkaz:
https://doaj.org/article/a9ea442961a64afa94499ce585b8ac1d
Autor:
Lisa Charlotte Heinig, Emily Valentina Madelaine Huth, Karsten Yan, Neele Schumacher, Mikolaj Nawrocki, Niels Christian Lory, Peter Bradtke, Tabea Bertram, Guido Rattay, Joanna Schmid, Samuel Huber, Thorsten Wiech, Dirk Schmidt-Arras, Stefan Rose-John, Hans-Willi Mittrücker
Publikováno v:
The Journal of Immunology. 210:1717-1727
IL-6 plays a fundamental role in T cell differentiation and is strictly controlled by surface expression and shedding of IL-6R. IL-6 also acts on other cells that might affect T cell maturation. To study the impact of cell-autonomous and uncontrolled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce32af72331795eb40e1e9af5aa7977
https://doi.org/10.4049/jimmunol.2200461
https://doi.org/10.4049/jimmunol.2200461
Autor:
Dirk Schmidt-Arras, Stefan Rose-John
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Interleukin-6 (IL-6) is the name-giving cytokine of a family of eleven members, including IL-6, CNTF, LIF, and IL-27. IL-6 was first recognized as a B-cell stimulating factor but we now know that the cytokine plays a pivotal role in the orchestration
Externí odkaz:
https://doaj.org/article/b692ebaa7fb3483e92dc272bae81f960
Autor:
Nofar Rosenberg, Matthias Van Haele, Tali Lanton, Neta Brashi, Zohar Bromberg, Hanan Adler, Hilla Giladi, Amnon Peled, Daniel S. Goldenberg, Jonathan H. Axelrod, Alina Simerzin, Chofit Chai, Mor Paldor, Auerlia Markezana, Dayana Yaish, Zohar Shemulian, Dvora Gross, Shanny Barnoy, Maytal Gefen, Osher Amran, Sofie Claerhout, Mirian Fernández-Vaquero, María García-Beccaria, Danijela Heide, Michal Shoshkes-Carmel, Dirk Schmidt Arras, Sharona Elgavish, Yuval Nevo, Hadar Benyamini, Janina E.E. Tirnitz-Parker, Aranzazu Sanchez, Blanca Herrera, Rifaat Safadi, Klaus H. Kaestner, Stefan Rose-John, Tania Roskams, Mathias Heikenwalder, Eithan Galun
Publikováno v:
Journal of Hepatology, 77(6), 1631-1641. Elsevier Science
BACKGROUND AND AIMS: Primary liver cancers include: Hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (CCA) and combined HCC-CCA tumors (cHCC-CCA). It has been suggested, but not unequivocally proven, that hepatic progenitor cells (HPCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35f9f989208ee8547dd302a2d0a5adb
https://cris.maastrichtuniversity.nl/en/publications/d57c548d-5429-4934-8f7c-86ffde92aab1
https://cris.maastrichtuniversity.nl/en/publications/d57c548d-5429-4934-8f7c-86ffde92aab1
Autor:
Jürgen Fritsch, Julia Frankenheim, Lothar Marischen, Timea Vadasz, Anja Troeger, Stefan Rose-John, Dirk Schmidt-Arras, Wulf Schneider-Brachert
Publikováno v:
Cells, Vol 10, Iss 11, p 3100 (2021)
Signaling via death receptor family members such as TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Pro-survival signaling is mediated via TNF-R1 complex I at the cellular plasma membrane. Ce
Externí odkaz:
https://doaj.org/article/2cc8bd0542a9418ea1186cc177177a4a
Publikováno v:
Journal of Renal and Hepatic Disorders, Vol 3, Iss 1 (2019)
Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as th
Externí odkaz:
https://doaj.org/article/aa6a783e26754c7ba23f2f8f3050ce91
Publikováno v:
Seminars in Immunopathology
The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines are mediators of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5623676a67b3b3cdd06365ca28d5fa1
http://europepmc.org/articles/PMC8443519
http://europepmc.org/articles/PMC8443519
Autor:
Dirk Schmidt-Arras, Stefan Rose-John
Publikováno v:
Cells, Vol 8, Iss 10, p 1226 (2019)
Fibrosis in the liver is mainly associated with the activation of hepatic stellate cells (HSCs). Both activation and clearance of HSCs can be mediated by ligand−receptor interactions. Members of the a disintegrin and metalloprotease (ADAM) family a
Externí odkaz:
https://doaj.org/article/6c31a6c0482d4d398d6a086c8e93dccc
Autor:
Dirk Schmidt-Arras, Frank-D. Böhmer
Publikováno v:
Trends in Molecular Medicine. 26:833-847
Activating mutations in genes encoding receptor tyrosine kinases (RTKs) mediate proliferation, cell migration, and cell survival, and are therefore important drivers of oncogenesis. Numerous targeted cancer therapies are directed against activated RT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e608a4f950d2f3d5e5241a5a21db916
https://doi.org/10.1016/j.molmed.2020.06.002
https://doi.org/10.1016/j.molmed.2020.06.002