Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Dirk Scharn"'
Autor:
Nina Kerres, Steffen Steurer, Stefanie Schlager, Gerd Bader, Helmut Berger, Maureen Caligiuri, Christian Dank, John R. Engen, Peter Ettmayer, Bernhard Fischerauer, Gerlinde Flotzinger, Daniel Gerlach, Thomas Gerstberger, Teresa Gmaschitz, Peter Greb, Bingsong Han, Elizabeth Heyes, Roxana E. Iacob, Dirk Kessler, Heike Kölle, Lyne Lamarre, David R. Lancia, Simon Lucas, Moriz Mayer, Katharina Mayr, Nikolai Mischerikow, Katja Mück, Christoph Peinsipp, Oliver Petermann, Ulrich Reiser, Dorothea Rudolph, Klaus Rumpel, Carina Salomon, Dirk Scharn, Renate Schnitzer, Andreas Schrenk, Norbert Schweifer, Diane Thompson, Elisabeth Traxler, Roland Varecka, Tilman Voss, Alexander Weiss-Puxbaum, Sandra Winkler, Xiaozhang Zheng, Andreas Zoephel, Norbert Kraut, Darryl McConnell, Mark Pearson, Manfred Koegl
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2860-2875 (2017)
The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We
Externí odkaz:
https://doaj.org/article/43ac770ae3294c078849cf3143253f8a
Autor:
Jürgen Moll, Natarajan Muthusamy, Norbert Kraut, Darryl B. McConnell, Mark Pearson, Segundo Gonzalez, Peter Ettmayer, Sumithira Vasu, Swagata Goswami, Girish Rajgolikar, Michael P. Sanderson, Thomas Gerstberger, Renate Schnitzer, Andreas Zoephel, Heribert Arnhof, Dirk Scharn, Jark Böttcher, Seila Lorenzo-Herrero, Marc Kerenyi, Sebastian Carotta, Maria A. Impagnatiello, Harald Engelhardt, Rajeswaran Mani, Marco H. Hofmann
Supplementary Data including Table S1-Table S5 and Figure S1 - Figure S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d553495bd4441df245e0ecc2903f83f
https://doi.org/10.1158/1535-7163.22520835
https://doi.org/10.1158/1535-7163.22520835
Autor:
Jürgen Moll, Natarajan Muthusamy, Norbert Kraut, Darryl B. McConnell, Mark Pearson, Segundo Gonzalez, Peter Ettmayer, Sumithira Vasu, Swagata Goswami, Girish Rajgolikar, Michael P. Sanderson, Thomas Gerstberger, Renate Schnitzer, Andreas Zoephel, Heribert Arnhof, Dirk Scharn, Jark Böttcher, Seila Lorenzo-Herrero, Marc Kerenyi, Sebastian Carotta, Maria A. Impagnatiello, Harald Engelhardt, Rajeswaran Mani, Marco H. Hofmann
Natural killer (NK) cells play a pivotal role in controlling cancer. Multiple extracellular receptors and internal signaling nodes tightly regulate NK activation. Cyclin-dependent kinases of the mediator complex (CDK8 and CDK19) were described as a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7267496a9a3dfd136c6ecb06ec5a6826
https://doi.org/10.1158/1535-7163.c.6542802.v1
https://doi.org/10.1158/1535-7163.c.6542802.v1
Autor:
Segundo Gonzalez, Dirk Scharn, Mark Pearson, Sebastian Carotta, Swagata Goswami, Natarajan Muthusamy, Heribert Arnhof, Sumithira Vasu, Norbert Kraut, Seila Lorenzo-Herrero, Harald Engelhardt, Michael P. Sanderson, Marc Kerenyi, Maria Antonietta Impagnatiello, Rajeswaran Mani, Renate Schnitzer, Jark Böttcher, Peter Ettmayer, Girish Rajgolikar, Marco H. Hofmann, Jürgen Moll, Andreas Zoephel, Darryl B. McConnell, Thomas Gerstberger
Publikováno v:
Mol Cancer Ther
Natural killer (NK) cells play a pivotal role in controlling cancer. Multiple extracellular receptors and internal signaling nodes tightly regulate NK activation. Cyclin-dependent kinases of the mediator complex (CDK8 and CDK19) were described as a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaac64dc345ae1363e27768a9e757d9
https://doi.org/10.1158/1535-7163.mct-19-0789
https://doi.org/10.1158/1535-7163.mct-19-0789
Autor:
Birgit Wilding, Dirk Scharn, Dietrich Böse, Anke Baum, Valeria Santoro, Paolo Chetta, Renate Schnitzer, Dana A. Botesteanu, Christoph Reiser, Stefan Kornigg, Petr Knesl, Alexandra Hörmann, Anna Köferle, Maja Corcokovic, Simone Lieb, Guido Scholz, Jens Bruchhaus, Markus Spina, Josef Balla, Biljana Peric-Simov, Jasmin Zimmer, Sophie Mitzner, Thomas N. Fett, Alexandra Beran, Lyne Lamarre, Thomas Gerstberger, Daniel Gerlach, Markus Bauer, Andreas Bergner, Andreas Schlattl, Gerd Bader, Matthias Treu, Harald Engelhardt, Stephan Zahn, Julian E. Fuchs, Johannes Zuber, Peter Ettmayer, Mark Pearson, Mark Petronczki, Norbert Kraut, Darryl B. McConnell, Flavio Solca, Ralph A. Neumüller
Publikováno v:
Nature cancer. 3(7)
Oncogenic alterations in human epidermal growth factor receptor 2 (HER2) occur in approximately 2% of patients with non-small cell lung cancer and predominantly affect the tyrosine kinase domain and cluster in exon 20 of the ERBB2 gene. Most clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57bd9ab03550201530aeff623cc359c
https://pubmed.ncbi.nlm.nih.gov/35883002
https://pubmed.ncbi.nlm.nih.gov/35883002
Autor:
Zhulin Tan, Nitinchandra D. Patel, Harald Engelhardt, Mark Petronczki, Georg Egger, Elisabeth Grondal, Lyne Lamarre, Joyce C. Leung, Bernadette Sharps, Nizar Haddad, Anke Baum, Andreas Bergner, Andreas Schrenk, Renate Schnitzer, Eugene Chong, Tobias Wunberg, Moriz Mayer, Thomas Gerstberger, Dietrich Böse, Andreas Zoephel, Darryl B. McConnell, Christian Engelhardt, Monika Kriz, Nina C. Gonnella, Mariusz Krawiec, Heinz Stadtmüller, Peter Ettmayer, Jonathan T. Reeves, Julian E. Fuchs, Barbara Hopfgartner, Dirk Scharn, Andreas Grimm, Biljana Peric Simov, Flavio Solca, Gerd Bader, Sandra Döbel, Roland Kousek
Publikováno v:
Journal of Medicinal Chemistry. 62:10272-10293
The epidermal growth factor receptor (EGFR), when carrying an activating mutation like del19 or L858R, acts as an oncogenic driver in a subset of lung tumors. While tumor responses to tyrosine kinase inhibitors (TKIs) are accompanied by marked tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d9f6cbebee7f9e20944c7e79b6bc3f
https://doi.org/10.1021/acs.jmedchem.9b01169
https://doi.org/10.1021/acs.jmedchem.9b01169
Autor:
Yugandhar Beesetty, Carrie F. Browning, Alex G. Waterson, Andrew J. Little, Jesse A. Coker, Michael C. Burns, Jiqing Sai, Timothy R. Hodges, Dhruba Sarkar, Jason R. Abbott, Jennifer E. Howes, Allison L. Arnold, Qi Sun, Stephen W. Fesik, Jason Phan, Denis T. Akan, Olivia W. Rossanese, Tammy Sobolik, James M. Salovich, Dirk Scharn, Darryl B. McConnell, Heinz Stadtmueller
Publikováno v:
J Med Chem
Son of sevenless homologue 1 (SOS1) is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS. In its active form, GTP-bound RAS is responsible for numerous critical cellular processes. Aberrant RAS activity is involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff60f993116e1c493cb7f3552884bdc
https://doi.org/10.1021/acs.jmedchem.8b01108
https://doi.org/10.1021/acs.jmedchem.8b01108
Autor:
Dirk Scharn, Harald Engelhardt, Janina Beck, Norbert Schweifer, Anke Baum, Thomas Gerstberger, Ulrike Tontsch-Grunt, Onur Kaya, Marco H. Hofmann, Johannes Popow, Johannes Zuber, Daniel Gerlach, Fabio Savarese, Norbert Kraut
Publikováno v:
Oncogene
Bromodomain and extra-terminal (BET) protein inhibitors have been reported as treatment options for acute myeloid leukemia (AML) in preclinical models and are currently being evaluated in clinical trials. This work presents a novel potent and selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73991aebe3c2d04f3bb645d6da3592f
https://doi.org/10.1038/s41388-018-0150-2
https://doi.org/10.1038/s41388-018-0150-2
Autor:
Daniel Gerlach, Markus Schaefer, Sabine Olt, Ulrike Tontsch-Grunt, Sebastian Carotta, Rebecca Langlois, Martin Aichinger, Sarah Rieser, Maria Antonietta Impagnatiello, Norbert Kraut, Johannes Zuber, Valeria Santoro, Andreas Wernitznig, Sabine Kallenda, Daniel Zach, Julian Jude, Martina Weissenboeck, Thomas Zichner, Melanie Talata De Almeida, Andrea Neudolt, Ksenija Slavic-Obradovic, Andreas Schlattl, Dirk Scharn, Martina Sykora, Markus Reschke, Michaela Fellner, Stefanie Ruhland, Florian Ebner, Juergen Moll, Carina Salomon
Publikováno v:
Cancer Research. 80:6221-6221
Background: Engagement of Tumor Necrosis Factor-α (TNF-α) with its receptor can lead to dramatically different cellular outcomes ranging from regulating cell survival and inflammation to induction of programmed forms of cell death. A critical proxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c634258996b7b748420180e5b3cff11
https://doi.org/10.1158/1538-7445.am2020-6221
https://doi.org/10.1158/1538-7445.am2020-6221
Autor:
David R. Lancia, John R. Engen, Elizabeth Heyes, Katharina Mayr, Lyne Lamarre, Mark Pearson, Carina Salomon, Simon Lucas, Steffen Steurer, Alexander Weiss-Puxbaum, Klaus Rumpel, Gerlinde Flotzinger, Norbert Kraut, Xiaozhang Zheng, Daniel Gerlach, Katja Mück, Sandra Winkler, Heike Kölle, Peter Ettmayer, Nikolai Mischerikow, Christian Dank, Ulrich Reiser, Dirk Scharn, Bingsong Han, Teresa Gmaschitz, Andreas Schrenk, Nina Kerres, Norbert Schweifer, Dirk Kessler, Tilman Voss, Renate Schnitzer, Manfred Koegl, Roland Varecka, Moriz Mayer, Dorothea Rudolph, Oliver Petermann, Diane Thompson, Thomas Gerstberger, Christoph Peinsipp, Roxana E. Iacob, Stefanie Schlager, Gerd Bader, Helmut Berger, Peter Greb, Maureen Caligiuri, Elisabeth Traxler, Bernhard Fischerauer, Andreas Zoephel, Darryl B. McConnell
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2860-2875 (2017)
Summary The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fde7bf1e49edbe7d290947dd0fdf49
https://pubmed.ncbi.nlm.nih.gov/28930682
https://pubmed.ncbi.nlm.nih.gov/28930682