Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Dirk Saerens"'
Publikováno v:
Sensors, Vol 8, Iss 8, Pp 4669-4686 (2008)
Today’s proteomic analyses are generating increasing numbers of biomarkers, making it essential to possess highly specific probes able to recognize those targets. Antibodies are considered to be the first choice as molecular recognition
Externí odkaz:
https://doaj.org/article/6f1b5d9f0d4848d8a08b6f0c604768d9
Autor:
Guy Caljon, Benoît Stijlemans, Dirk Saerens, Jan Van Den Abbeele, Serge Muyldermans, Stefan Magez, Patrick De Baetselier
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 12 (2012)
Externí odkaz:
https://doaj.org/article/981c95463f5a4a838a331ad8b43d7102
Autor:
Guy Caljon, Benoît Stijlemans, Dirk Saerens, Jan Van Den Abbeele, Serge Muyldermans, Stefan Magez, Patrick De Baetselier
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 11, p e1902 (2012)
BACKGROUND: The discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites. The anti-trypanosomal activity relies on perturbing the high
Externí odkaz:
https://doaj.org/article/3894b70394804fe885feec3f4191e617
Autor:
Benoît Stijlemans, Guy Caljon, Senthil Kumar A Natesan, Dirk Saerens, Katja Conrath, David Pérez-Morga, Jeremy N Skepper, Alexandros Nikolaou, Lea Brys, Etienne Pays, Stefan Magez, Mark C Field, Patrick De Baetselier, Serge Muyldermans
Publikováno v:
PLoS Pathogens, Vol 7, Iss 6, p e1002072 (2011)
The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a high
Externí odkaz:
https://doaj.org/article/a7f47e4a605e405ca7807a71666c3a46
Autor:
Dirk Saerens, Yoshihisa Hagihara
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1844:2016-2023
Antibodies have evolved to function in oxidative, extracellular environments. A pair of cysteines in close proximity will oxidatively react to form a disulfide bond that fixes and stabilizes the tertiary structure of a protein. Immunoglobulin G (IgG)
Autor:
Jeremy N. Skepper, Dirk Saerens, Senthil Kumar A. Natesan, Lea Brys, Mark C. Field, Alexandros Nikolaou, Serge Muyldermans, Stefan Magez, Etienne Pays, David Perez-Morga, Katja Conrath, Benoit Stijlemans, Patrick De Baetselier, Guy Caljon
Publikováno v:
Vrije Universiteit Brussel
PLoS Pathogens, Vol 7, Iss 6, p e1002072 (2011)
PLoS Pathogens
P L o S Pathogens, 7 (6
PLoS Pathogens, Vol 7, Iss 6, p e1002072 (2011)
PLoS Pathogens
P L o S Pathogens, 7 (6
The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion. Specifically, antigenic variation of the variant-specific surface glycoprotein (VSG) and a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b0c24441acd735f0e34b460deb7685
https://doi.org/10.1371/journal.ppat.1002072
https://doi.org/10.1371/journal.ppat.1002072
Autor:
Serge Muyldermans, Cécile Vincke, Nick Deschacht, Dirk Saerens, Jochen Govaert, Mireille Pellis, Katja Conrath
Publikováno v:
Journal of Biological Chemistry. 287:1970-1979
The antigen-binding fragment of functional heavy chain antibodies (HCAbs) in camelids comprises a single domain, named the variable domain of heavy chain of HCAbs (VHH). The VHH harbors remarkable amino acid substitutions in the framework region-2 to
Autor:
Naima Abidi, Serge Muyldermans, Rahma Ben Abderrazek, Dirk Saerens, Balkiss Bouhaouala-Zahar, Issam Hmila, Mohamed El Ayeb, Cécile Vincke
Publikováno v:
Protein Engineering, Design and Selection
Protein Engineering, Design and Selection, Oxford University Press (OUP), 2011, 24 (9), pp.727-35. ⟨10.1093/protein/gzr037⟩
Vrije Universiteit Brussel
Protein Engineering, Design and Selection, Oxford University Press (OUP), 2011, 24 (9), pp.727-35. ⟨10.1093/protein/gzr037⟩
Vrije Universiteit Brussel
International audience; During scorpion envenoming, highly toxic small polypeptides of the venom diffuse rapidly within the victim, causing serious medical problems. Nanobodies (Nbs), the recombinant single-domain antigen-binding fragments of camel-s
Autor:
Gholamreza Hassanzadeh-Ghassabeh, Serge Muyldermans, Bert Thys, Bart Rombaut, Gerrit De Bleeser, Lise Schotte, Dirk Saerens
Publikováno v:
Journal of Virological Methods. 173:300-305
Recently, single-domain recombinant antibody fragments (VHHs or nanobodies) against poliovirus type 1 were isolated. To examine the antigenicity of poliovirus using these recombinant VHHs, an alternative technique mimicking protein A immunoprecipitat
Publikováno v:
Expert Review of Molecular Diagnostics. 10:777-785
With the advent of new antibody engineering technologies, conventional antibodies have been minimized into smaller antibody formats. Small size is an important advantage for current and future diagnostic development. Nanobodies® (Ablynx) are among t