Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dirk Ruesch"'
Publikováno v:
Anesthesiology. 116:47-55
Background Propofol produces its major actions via γ-aminobutyric acid type A (GABA(A)) receptors. At low concentrations, propofol enhances agonist-stimulated GABA(A) receptor activity, and high propofol concentrations directly activate receptors. E
Publikováno v:
The Open Critical Care Medicine Journal. 1:7-11
Background: The goal of Basic Life Support is the oxygenation of vital organs during cardiac arrest. Therefore, chest compressions are combined with ventilation in a fixed ratio. This study investigated the influence of bag/mask venti- lation on pulm
Publikováno v:
The Journal of Neuroscience. 27:13151-13160
Serotonin type 3 (5-HT3) receptors are members of the pentameric Cys-loop superfamily of receptors that modulate synaptic neurotransmission. In response to agonist binding and unbinding, members of this superfamily undergo a series of conformational
Autor:
Dirk Ruesch, S. Shaukat Husain, Keith W. Miller, Jonathan B. Cohen, Stuart A. Forman, Enrique Arevalo, Filbert Hong, Michael R. Ziebell, Richard W. Olsen, Jonathan A. Kosterlitz
Publikováno v:
Journal of Medicinal Chemistry. 46:1257-1265
To locate general anesthetic binding sites on ligand-gated ion channels, a diazirine derivative of the potent intravenous anesthetic, R-(+)-etomidate (2-ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate), has been synthesized and characterized. R-(+
Background Etomidate acts at gamma-Aminobutyric acid type A (GABAA) receptors containing beta2 or beta3, but not beta1 subunits. Mutations at beta residue 265 (Ser in beta1; Asn in beta2 or beta3) profoundly affect etomidate sensitivity. Whether thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba6dd06ac83252f317123c44bb7e238
https://europepmc.org/articles/PMC2798018/
https://europepmc.org/articles/PMC2798018/
Autor:
Stuart A. Forman, Selvanayagam Nirthanan, Guodong Li, Keith W. Miller, Ken Solt, Richard W. Olsen, S. Shaukat Husain, Qi Cheng, Dirk Ruesch, Enrique Arevalo, Douglas E. Raines, Jonathan B. Cohen
Publikováno v:
Journal of medicinal chemistry. 49(16)
To locate the binding sites of general anesthetics on ligand-gated ion channels, two derivatives of the intravenous general anesthetic etomidate (2-ethyl 1-(phenylethyl)-1H-imidazole-5-carboxylate), in which the 2-ethyl group has been replaced by pho
Publikováno v:
Anesthesiology. 96:A1265