Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Dirk M, Nettelbeck"'
Autor:
Stefan Joos, Dirk M. Nettelbeck, Anette Reil‐Held, Katja Engelmann, Alexandra Moosmann, Angelika Eggert, Wolfgang Hiddemann, Mechthild Krause, Christoph Peters, Martin Schuler, Klaus Schulze‐Osthoff, Hubert Serve, Wolfgang Wick, Josef Puchta, Michael Baumann
Publikováno v:
Molecular Oncology, Vol 13, Iss 3, Pp 535-542 (2019)
The German Cancer Consortium (‘Deutsches Konsortium für Translationale Krebsforschung’, DKTK) is a long‐term cancer consortium, bringing together the German Cancer Research Center (DKFZ), Germany's largest life science research center, and the
Externí odkaz:
https://doaj.org/article/52ff11e087e14d8197c990619a3e66d0
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Cancer therapeutics approved for clinical application include oncolytic viruses and antibodies, which evolved by nature, but were improved by molecular engineering. Both facilitate outstanding tumor selectivity and pleiotropic activities, but also fa
Externí odkaz:
https://doaj.org/article/efb7def1050c412b8a11a7aaf395721f
Autor:
Dirk M. Nettelbeck, Mathias F. Leber, Jennifer Altomonte, Assia Angelova, Julia Beil, Susanne Berchtold, Maike Delic, Jürgen Eberle, Anja Ehrhardt, Christine E. Engeland, Henry Fechner, Karsten Geletneky, Katrin Goepfert, Per Sonne Holm, Stefan Kochanek, Florian Kreppel, Lea Krutzke, Florian Kühnel, Karl Sebastian Lang, Antonio Marchini, Markus Moehler, Michael D. Mühlebach, Ulrike Naumann, Roman Nawroth, Jürg Nüesch, Jean Rommelaere, Ulrich M. Lauer, Guy Ungerechts
Publikováno v:
Viruses, Vol 13, Iss 8, p 1420 (2021)
Virotherapy research involves the development, exploration, and application of oncolytic viruses that combine direct killing of cancer cells by viral infection, replication, and spread (oncolysis) with indirect killing by induction of anti-tumor immu
Externí odkaz:
https://doaj.org/article/2afbc836e8844aa9a40984a8fca1af73
Autor:
Riikka Havunen, Mikko Siurala, Suvi Sorsa, Susanna Grönberg-Vähä-Koskela, Michael Behr, Siri Tähtinen, João Manuel Santos, Pauliina Karell, Juuso Rusanen, Dirk M. Nettelbeck, Anja Ehrhardt, Anna Kanerva, Akseli Hemminki
Publikováno v:
Molecular Therapy: Oncolytics, Vol 4, Iss C, Pp 77-86 (2017)
Adoptive cell therapy holds much promise in the treatment of cancer but results in solid tumors have been modest. The notable exception is tumor-infiltrating lymphocyte (TIL) therapy of melanoma, but this approach only works with high-dose preconditi
Externí odkaz:
https://doaj.org/article/ee6fb35e852f4da1817ebf04ed9d2d6f
Autor:
Dirk M. Nettelbeck, David T. Curiel, Thomas R. Broker, Louise T. Chow, Minghui Wang, Angel A. Rivera, N. Sanjib Banerjee
We have generated novel conditionally replicative adenoviruses (CRAds) targeted to melanoma cells. In these adenoviruses, the E4 region (AdΔ24TyrE4) or both E1 and E4 regions (Ad2xTyr) were controlled by a synthetic tyrosinase enhancer/promoter (Tyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2527e9824ea87d37389a39e8048b45de
https://doi.org/10.1158/1535-7163.c.6532106
https://doi.org/10.1158/1535-7163.c.6532106
Autor:
Ilka Knippertz, Andrea Deinzer, Jan Dörrie, Niels Schaft, Dirk M. Nettelbeck, Alexander Steinkasserer
Publikováno v:
Journal of Immunology Research, Vol 2016 (2016)
To specifically target dendritic cells (DCs) to simultaneously express different therapeutic transgenes for inducing immune responses against tumors, we used a combined promoter system of adenoviral vectors. We selected a 216 bp short Hsp70B′ core
Externí odkaz:
https://doaj.org/article/e9134c94b29545eaa243b7805a594b46
Autor:
Guy Ungerechts, Sascha Bossow, Barbara Leuchs, Per S Holm, Jean Rommelaere, Matt Coffey, Rob Coffin, John Bell, Dirk M Nettelbeck
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Oncolytic viruses (OVs) are unique anticancer agents based on their pleotropic modes of action, which include, besides viral tumor cell lysis, activation of antitumor immunity. A panel of diverse viruses, often genetically engineered, has advanced to
Externí odkaz:
https://doaj.org/article/0ae5904ce6684981aeeee2ff23c841d3
Autor:
Ernst Wagner, Claudio Mussolino, Dirk M. Nettelbeck, Boris Fehse, Wolfgang Uckert, Toni Cathomen, Christian Kupatt, Hildegard Büning, Axel Schambach, Stefan Kochanek, Ulrike Koehl, Zoltán Ivics
Publikováno v:
Human gene therapy. 32(19-20)
Gene therapies have been successfully applied to treat severe inherited and acquired disorders. Although research and development are sufficiently well funded in Germany and while the output of scientific publications and patents is comparable with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04cb29b3fa50701bdd556c31e1024ab
https://pubmed.ncbi.nlm.nih.gov/34662229
https://pubmed.ncbi.nlm.nih.gov/34662229
Autor:
Hubert Serve, Alexandra Moosmann, Stefan Joos, Klaus Schulze-Osthoff, Dirk M. Nettelbeck, Wolfgang Hiddemann, Angelika Eggert, Josef Puchta, Martin Schuler, Anette Reil-Held, Christoph Peters, Katja Engelmann, Wolfgang Wick, Michael Baumann, Mechthild Krause
Publikováno v:
Molecular Oncology, Vol 13, Iss 3, Pp 535-542 (2019)
Molecular Oncology
Molecular Oncology
The German Cancer Consortium (‘Deutsches Konsortium für Translationale Krebsforschung’, DKTK) is a long-term cancer consortium, bringing together the German Cancer Research Center (DKFZ), Germany's largest life science research center, and the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ab9c50b460c617122b80fc353b0f17
https://doaj.org/article/52ff11e087e14d8197c990619a3e66d0
https://doaj.org/article/52ff11e087e14d8197c990619a3e66d0
Autor:
Michael Behr, Johanna K Kaufmann, Patrick Ketzer, Sarah Engelhardt, Martin Mück-Häusl, Pamela M Okun, Gabriele Petersen, Frank Neipel, Jessica C Hassel, Anja Ehrhardt, Alexander H Enk, Dirk M Nettelbeck
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95723 (2014)
Adenoviral gene therapy and oncolysis would critically benefit from targeted cell entry by genetically modified capsids. This requires both the ablation of native adenovirus tropism and the identification of ligands that remain functional in virus co
Externí odkaz:
https://doaj.org/article/0d5eab96f90d4bbea3c40ff9fa1dd40b