Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Dirk Lindeman"'
Autor:
Alexander Gerbaulet, Rayk Behrendt, Benjamin Gabriel, Martin Kleefisch, Min Ae Lee-Kirsch, Axel Roers, Martin Achleitner, Uwe Fiebig, Anastasia Polikarpova, Reinhard Oertel, Alexander Hennig, Livia Schulze, Katrin Peschke, Dirk Lindeman
Publikováno v:
The Journal of Immunology. 199:2261-2269
Biallelic mutations of three prime repair exonuclease 1 (TREX1) cause the lupus-like disease Aicardi–Goutières syndrome in which accumulation of a yet unknown endogenous DNA substrate of TREX1 triggers a cyclic GMP–AMP synthase-dependent type I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee5ef202789f65933d8ab8fe2003969
https://doi.org/10.4049/jimmunol.1700714
https://doi.org/10.4049/jimmunol.1700714
Autor:
Juan A. Bueren, Susana Navarro, Jennifer E. Adair, Paula Río, Michael Antoniou, Cynthia C. Bartholomae, Julián Sevilla, Pamela S. Becker, Anne Galy, Adrian J. Thrasher, Bruce R. Blazar, David A. Williams, Marina Cavazzana-Calvo, Thomas Carroll, Luigi Naldini, Robert Dalgleish, Els Verhoeyen, Helmut Hanenberg, Raffaele Renella, H. Bobby Gaspar, D. Wade Clapp, Dirk Lindeman, Hans-Peter Kiem, Jakub Tolar, John E. Wagner, Manfred Schmidt, Christof von Kalle
Publikováno v:
Molecular Therapy; Vol 19
Molecular Therapy
Molecular Therapy, Cell Press, 2011, 19 (7), pp.1193-8. ⟨10.1038/mt.2011.78⟩
Molecular Therapy, 2011, 19 (7), pp.1193-8. ⟨10.1038/mt.2011.78⟩
Molecular Therapy
Molecular Therapy, Cell Press, 2011, 19 (7), pp.1193-8. ⟨10.1038/mt.2011.78⟩
Molecular Therapy, 2011, 19 (7), pp.1193-8. ⟨10.1038/mt.2011.78⟩
Survival rates after allogeneic hematopoietic cell transplantation (HCT) for Fanconi anemia (FA) have increased dramatically since 2000. However, the use of autologous stem cell gene therapy, whereby the patient's own blood stem cells are modified to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972e99d15287ee06abcb4d938647669c
Autor:
Clara Marie Munz, Henriette Kreher, Alexander Erdbeer, Stefanie Richter, Dana Westphal, Buqing Yi, Rayk Behrendt, Nicole Stanke, Fabian Lindel, Dirk Lindemann
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 394-412 (2022)
Foamy viruses (FVs) or heterologous retroviruses pseudotyped with FV glycoprotein enable transduction of a great variety of target tissues of disparate species. Specific cellular entry receptors responsible for this exceptionally broad tropism await
Externí odkaz:
https://doaj.org/article/044c613578284b6f96968e002a24ff59
Autor:
Charlotte Steenblock, Stefanie Richter, Ilona Berger, Marko Barovic, Janine Schmid, Undine Schubert, Natalia Jarzebska, Anne von Mässenhausen, Andreas Linkermann, Annette Schürmann, Jessica Pablik, Thomas Dienemann, Katja Evert, Roman N. Rodionov, Natalia Y. Semenova, Vsevolod A. Zinserling, Raul R. Gainetdinov, Gustavo Baretton, Dirk Lindemann, Michele Solimena, Barbara Ludwig, Stefan R. Bornstein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
New-onset hyperglycemia and complications of preexisting diabetes have been observed in COVID-19 patients, however, the underlying mechanisms are not fully understood. Here, the authors show that SARS-CoV-2 is detectable in both endocrine and exocrin
Externí odkaz:
https://doaj.org/article/ec0c8556edd84043baaaaa998aa628a8
Individual HLA-A, -B, -C, and -DRB1 Genotypes Are No Major Factors Which Determine COVID-19 Severity
Autor:
Johannes Schetelig, Falk Heidenreich, Henning Baldauf, Sarah Trost, Bose Falk, Christian Hoßbach, Ruben Real, Axel Roers, Dirk Lindemann, Alexander Dalpke, Martin Kolditz, Katja de With, Martin Bornhäuser, Ezio E. Bonifacio, Elke Rücker-Braun, Vinzenz Lange, Jan Markert, Ralf Barth, Jan A. Hofmann, Jürgen Sauter, Stefanie N. Bernas, Alexander H. Schmidt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
HLA molecules are key restrictive elements to present intracellular antigens at the crossroads of an effective T-cell response against SARS-CoV-2. To determine the impact of the HLA genotype on the severity of SARS-CoV-2 courses, we investigated data
Externí odkaz:
https://doaj.org/article/9c792e9eb8444f45a4ce94afa0664139
Autor:
Fabian Lindel, Carolin R. Dodt, Niklas Weidner, Monique Noll, Fabian Bergemann, Rayk Behrendt, Sarah Fischer, Josephine Dietrich, Marc Cartellieri, Martin V. Hamann, Dirk Lindemann
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 708-726 (2019)
The adaptation of CRISPR/Cas technology for use in mammals has revolutionized genome engineering. In particular with regard to clinical application, efficient expression of Cas9 within a narrow time frame is highly desirable to minimize the accumulat
Externí odkaz:
https://doaj.org/article/36bae1567ab84d818e9e97c53017f3b3
Autor:
Jennifer Donau, Huan Luo, Iiris Virta, Annett Skupin, Margarita Pushina, Jana Loeffler, Frauke V. Haertel, Anupam Das, Thomas Kurth, Michael Gerlach, Dirk Lindemann, Peter S. Reinach, Stefan Mergler, Monika Valtink
Publikováno v:
Membranes, Vol 12, Iss 3, p 281 (2022)
The functional contribution of transient receptor potential vanilloid 4 (TRPV4) expression in maintaining human corneal endothelial cells (HCEC) homeostasis is unclear. Accordingly, we determined the effects of TRPV4 gene and protein overexpression o
Externí odkaz:
https://doaj.org/article/62217a0e5400493ab9c9ac586cf5c0f0
Autor:
John R. Counsell, Rajvinder Karda, Juan Antinao Diaz, Louise Carey, Tatiana Wiktorowicz, Suzanne M.K. Buckley, Shima Ameri, Joanne Ng, Julien Baruteau, Filipa Almeida, Rohan de Silva, Roberto Simone, Eleonora Lugarà, Gabriele Lignani, Dirk Lindemann, Axel Rethwilm, Ahad A. Rahim, Simon N. Waddington, Steven J. Howe
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 626-634 (2018)
Viral vectors are rapidly being developed for a range of applications in research and gene therapy. Prototype foamy virus (PFV) vectors have been described for gene therapy, although their use has mainly been restricted to ex vivo stem cell modificat
Externí odkaz:
https://doaj.org/article/6238edf25cf544478737c499f40dbd36
Autor:
Sumitra Srimasorn, Matthias Kirsch, Susanne Hallmeyer-Ellgner, Dirk Lindemann, Alexander Storch, Andreas Hermann
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Human pluripotent stem cells (hPSCs), including induced pluripotent stem cells (iPSCs), provide access to hard-to-obtain cells for studies under physiological and disease conditions. For the study of neurodegenerative diseases, especially sporadic ca
Externí odkaz:
https://doaj.org/article/a59838d2db3a4093a6981b341411e905
Publikováno v:
Viruses, Vol 13, Iss 1, p 105 (2021)
Within the family of Retroviridae, foamy viruses (FVs) are unique and unconventional with respect to many aspects in their molecular biology, including assembly and release of enveloped viral particles. Both components of the minimal assembly and rel
Externí odkaz:
https://doaj.org/article/5f82a4fd6d90401680a3ee8003580a76