Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dirk L. Teagarden"'
Autor:
Evgenyi Shalaev, Jayesh Sonje, Raj Suryanarayanan, Susan W. H. Martin, Dirk L. Teagarden, Bakul Bhatnagar
Publikováno v:
Physical Chemistry Chemical Physics. 22:1583-1590
While water is the solvent of choice for the lyophilization of pharmaceuticals, tert-butyl alcohol (TBA) along with water can confer several advantages including increased solubility of hydrophobic drugs, decreased drying time, improved product stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f95a7641c3e69c5d83dbf7128984d5a
https://doi.org/10.1039/c9cp06576h
https://doi.org/10.1039/c9cp06576h
Publikováno v:
Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products ISBN: 9780429151859
INTRODUCTION Freeze-drying of pharmaceutical and biological solutions to produce an elegant stable powder has been a standard practice employed to manufacture many marketed pharmaceutical and biological products for over 50 years. The vast majority o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16277f47e7e9d599fbba4a031b9afbcf
https://doi.org/10.3109/9781439825761-13
https://doi.org/10.3109/9781439825761-13
Autor:
Dirk L. Teagarden, Tapan K. Das, Evgenyi Shalaev, Liji Joseph, Bakul Bhatnagar, Susan W. H. Martin, Hodge Tamara Shafer, Raj Suryanarayanan
Publikováno v:
Journal of Pharmaceutical Sciences. 100:3062-3075
The objectives of the current study were to investigate (i) the phase behavior of a PEGylated recombinant human growth hormone (PEG-rhGH, ∼60 kDa) during freeze-drying and (ii) its storage stability. The phase transitions during freeze-thawing of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951f550680ccfb2e116ee3e1e2e9b7e6
https://doi.org/10.1002/jps.22562
https://doi.org/10.1002/jps.22562
Autor:
Robert E. Johnson, Claire E. Madden-Smith, Delphine Le Roux, Saleem S. Ahmed, Dirk L. Teagarden, David O. Bates, S Rigby-Singleton, Lavinia M. Lewis, Mark Perkins, Andrew Parker, Clive J. Roberts
Publikováno v:
Journal of Pharmaceutical Sciences. 99:4616-4629
This work investigated the impact of primary drying conditions on the microstructure and protein stability of bovine serum albumin (BSA) containing lyophilized cakes. Two primary drying conditions were employed (termed ‘conservative’, slower dryi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44847603323c4da92256d1e090c262c7
https://doi.org/10.1002/jps.22185
https://doi.org/10.1002/jps.22185
Autor:
Speaker Stanley M, Thomas J. Thamann, Tore Ramstad, Dirk L. Teagarden, Gary E. Martin, Chad E. Hadden
Publikováno v:
International Journal of Pharmaceutics. 296:55-63
A binding constant was determined for the complexation reaction between alprostadil (PGE1) and alpha-cyclodextrin (alpha-CD). This constant was used to calculate the fraction PGE1 free upon reconstitution of Caverject dual chamber syringe, indicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3d425568cd213e1b8b8907d512c9db
https://doi.org/10.1016/j.ijpharm.2005.02.018
https://doi.org/10.1016/j.ijpharm.2005.02.018
Publikováno v:
Advanced Drug Delivery Reviews. 20:155-164
The partitioning of PGE1 in a lipid emulsion has been shown to be consistent with a three-phase model which assumes that solute may reside in the bulk aqueous and oil phases and at the oil-water interface. Ultrafiltration and dialysis techniques were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::046b8fb2f5a00d27683e57d8b9fc1020
https://doi.org/10.1016/0169-409x(95)00118-q
https://doi.org/10.1016/0169-409x(95)00118-q
Publikováno v:
Journal of pharmaceutical sciences. 99(11)
Our objective was to characterize, by DSC and XRD, the equilibrium thermal behavior of frozen aqueous solutions containing polyethylene glycol (PEG) and sucrose. Aqueous solutions of (i) PEG (2.5-50% w/w), (ii) sucrose (10% w/v) with different concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295d6f522e65a6c0fda2c5bd650e3f03
https://pubmed.ncbi.nlm.nih.gov/20845450
https://pubmed.ncbi.nlm.nih.gov/20845450
Autor:
Bakul S. Bhatnagar, Susan M. Martin, Dirk L. Teagarden, Evgenyi Y. Shalaev, Raj Suryanarayanan
Publikováno v:
Journal of pharmaceutical sciences. 99(6)
Our objective was to characterize the nonequilibrium thermal behavior of frozen aqueous solutions containing PEG and sucrose. Aqueous solutions of (i) sucrose (10%, w/v) with different concentrations of PEG (1-20%, w/v), and (ii) PEG (10%, w/v) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e81867e034d3dbbb332ccb4c29374a2
https://pubmed.ncbi.nlm.nih.gov/20091827
https://pubmed.ncbi.nlm.nih.gov/20091827
Publikováno v:
International journal of pharmaceutics. 390(2)
Proteins generally will tend to aggregate under a variety of environmental conditions in comparison with small drug molecules. The extent of aggregation is dependent on many factors that can be broadly classified as intrinsic (primary, secondary, ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eec1e5f81053ed70fc00c006cdbd532
https://pubmed.ncbi.nlm.nih.gov/20188160
https://pubmed.ncbi.nlm.nih.gov/20188160
Autor:
David S. Baker, Dirk L. Teagarden
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 15(2)
Non-aqueous co-solvent systems have been evaluated for their potential use in the freeze-drying of pharmaceutical products. The advantages of using these non-aqueous solvent systems include: increased drug wetting or solubility, increased sublimation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8ac08ec592bc5155ef3abe5327fea9
https://pubmed.ncbi.nlm.nih.gov/11849908
https://pubmed.ncbi.nlm.nih.gov/11849908