Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dirk J. Slotboom"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cellular homeostasis depends on the supply of metabolic energy in the form of ATP and electrochemical ion gradients. The construction of synthetic cells requires a constant supply of energy to drive membrane transport and metabolism. Here, w
Externí odkaz:
https://doaj.org/article/85f29c3a80cc43e6a9e594ec94c07a7d
Autor:
Anna M. Borowska, Maria Gabriella Chiariello, Alisa A. Garaeva, Jan Rheinberger, Siewert J. Marrink, Cristina Paulino, Dirk J. Slotboom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract ASCT2 is an obligate exchanger of neutral amino acids, contributing to cellular amino acid homeostasis. ASCT2 belongs to the same family (SLC1) as Excitatory Amino Acid Transporters (EAATs) that concentrate glutamate in the cytosol. The mech
Externí odkaz:
https://doaj.org/article/9fd4fa60482e4bd8bd187afb119c679a
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract BacA is a mycobacterial ATP-binding cassette (ABC) transporter involved in the translocation of water-soluble compounds across the lipid bilayer. Whole-cell-based assays have shown that BacA imports cobalamin as well as unrelated hydrophilic
Externí odkaz:
https://doaj.org/article/128177cbcc9849f08942e44fabe07375
Autor:
Eleonora Diamanti, Paulo C. T. Souza, Inda Setyawati, Spyridon Bousis, Leticia Monjas, Lotteke J.Y.M. Swier, Atanaz Shams, Aleksei Tsarenko, Weronika K. Stanek, Manuel Jäger, Siewert J. Marrink, Dirk J. Slotboom, Anna K. H. Hirsch
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract The energy-coupling factor (ECF) transporters are a family of transmembrane proteins involved in the uptake of vitamins in a wide range of bacteria. Inhibition of the activity of these proteins could reduce the viability of pathogens that de
Externí odkaz:
https://doaj.org/article/cb7fa63baaae402daad67c5aaefc6bbd
Autor:
Chancievan Thangaratnarajah, Mark Nijland, Luís Borges-Araújo, Aike Jeucken, Jan Rheinberger, Siewert J. Marrink, Paulo C. T. Souza, Cristina Paulino, Dirk J. Slotboom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Energy-coupling factor (ECF)-type transporters mediate the uptake of micronutrients in many bacteria. They consist of a substrate-translocating subunit (S-component) and an ATP-hydrolysing motor (ECF module) Previous data indicate that the S
Externí odkaz:
https://doaj.org/article/a86a02f4371e40bf9108dd6718f5be87
Autor:
Emanuela Colucci, Zaid R. Anshari, Miyer F. Patiño-Ruiz, Mariia Nemchinova, Jacob Whittaker, Dirk J. Slotboom, Albert Guskov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Episodic ataxias (EAs) are rare neurological conditions that cause motor impairment. Here the authors investigated the molecular mechanism of such a pathological condition caused by a mutation of a conserved proline into arginine residue.
Externí odkaz:
https://doaj.org/article/dafbb430cae04e6aaf9a15a554186aee
Autor:
Eleonora Diamanti, Paulo C. T. Souza, Inda Setyawati, Spyridon Bousis, Leticia Monjas, Lotteke J.Y.M. Swier, Atanaz Shams, Aleksei Tsarenko, Weronika K. Stanek, Manuel Jäger, Siewert J. Marrink, Dirk J. Slotboom, Anna K. H. Hirsch
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/a48c550ad9f746d9bae5648d35e2e359
Autor:
Gianluca Trinco, Valentina Arkhipova, Alisa A. Garaeva, Cedric A. J. Hutter, Markus A. Seeger, Albert Guskov, Dirk J. Slotboom
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Trinco et al. measure aspartate uptake rates in proteoliposomes containing purified prokaryotic Na+-coupled aspartate transporter GltTk. To overcome limitation of protein orientation, they use synthetic nanobody that blocks transporters from outside
Externí odkaz:
https://doaj.org/article/76bc5140efca4c9482b7af7a5ab080f1
Autor:
Ignacio Faustino, Haleh Abdizadeh, Paulo C. T. Souza, Aike Jeucken, Weronika K. Stanek, Albert Guskov, Dirk J. Slotboom, Siewert J. Marrink
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Energy coupling factor (ECF) transporters are responsible for the uptake of micronutrients and consist of an integral membrane unit, the S-component, which confers substrate specificity. Here, authors present multi-scale molecular dynamics simulation
Externí odkaz:
https://doaj.org/article/8db3b4bf1fbd48c08e8894be97681363
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Glutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explai
Externí odkaz:
https://doaj.org/article/5a15e2c8a0a34570bdd68f209b8447e0