Zobrazeno 1 - 10
of 782
pro vyhledávání: '"Dirk J, Duncker"'
Autor:
Jorik H. Amesz, MSc, Sanne J.J. Langmuur, BSc, Mark F.A. Bierhuizen, MD, LLM, Dwight Dumay, BSc, Pieter C. van de Woestijne, MD, Jelena Sjatskig, MD, Lisa E. Sluijter, MSc, Dirk J. Duncker, MD, PhD, Olivier C. Manintveld, MD, PhD, Yannick J.H.J. Taverne, MD, PhD, MSc
Publikováno v:
JHLT Open, Vol 6, Iss , Pp 100159- (2024)
Background: This study investigated oxygen handling of human hearts donated after circulatory death (DCD) on normothermic ex-situ heart perfusion (ESHP) and evaluated oxygen handling markers as adjuncts to cardiac viability assessment. Methods: This
Externí odkaz:
https://doaj.org/article/9ea7165bce94486e818ee49f3d40fc84
Autor:
Francesca Razzi, Jouke Dijkstra, Ayla Hoogendoorn, Karen Witberg, Jurgen Ligthart, Dirk J. Duncker, Jan van Esch, Jolanda J. Wentzel, Volkert van Steijn, Gijs van Soest, Evelyn Regar, Heleen M. M. van Beusekom
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Safety and efficacy of coronary drug-eluting stents (DES) are often preclinically tested using healthy or minimally diseased swine. These generally show significant fibrotic neointima at follow-up, while in patients, incomplete healing is of
Externí odkaz:
https://doaj.org/article/8100e34e390c48c59235ae0ae3e2d934
Autor:
Nuria Slijkhuis, Francesca Razzi, Suze-Anne Korteland, Bram Heijs, Kim van Gaalen, Dirk J. Duncker, Antonius F.W. van der Steen, Volkert van Steijn, Heleen M.M. van Beusekom, Gijs van Soest
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100504- (2024)
Coronary atherosclerosis is caused by plaque build-up, with lipids playing a pivotal role in its progression. However, lipid composition and distribution within coronary atherosclerosis remain unknown. This study aims to characterize lipids and inves
Externí odkaz:
https://doaj.org/article/34e3e0defba24f9090b9be90a38e5f97
Autor:
Zongye Cai, Siyu Tian, Theo Klein, Ly Tu, Laurie W. Geenen, Thomas Koudstaal, Annemien E. van den Bosch, Yolanda B. de Rijke, Irwin K. M. Reiss, Eric Boersma, Claude van der Ley, Martijn Van Faassen, Ido Kema, Dirk J. Duncker, Karin A. Boomars, Karin Tran-Lundmark, Christophe Guignabert, Daphne Merkus
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Activation of the kynurenine pathway (KP) has been reported in patients with pulmonary arterial hypertension (PAH) undergoing PAH therapy. We aimed to determine KP-metabolism in treatment-naïve PAH patients, investigate its prognostic value
Externí odkaz:
https://doaj.org/article/79f725107d30412dac03fd519e49b69d
Autor:
Merel Stok, Helen de Boer, Marshall W. Huston, Edwin H. Jacobs, Onno Roovers, Trudi P. Visser, Holger Jahr, Dirk J. Duncker, Elza D. van Deel, Arnold J.J. Reuser, Niek P. van Til, Gerard Wagemaker
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 1014-1025 (2020)
Pompe disease is an autosomal recessive lysosomal storage disorder characterized by progressive muscle weakness. The disease is caused by mutations in the acid α-glucosidase (GAA) gene. Despite the currently available enzyme replacement therapy (ERT
Externí odkaz:
https://doaj.org/article/81835f573420466a90338ee21c4f9707
Autor:
Markus Hecker, Dirk J. Duncker
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/3ba2035383e549a6b2546f1af2f36162
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The coronary microvasculature plays a key role in regulating the tight coupling between myocardial perfusion and myocardial oxygen demand across a wide range of cardiac activity. Short-term regulation of coronary blood flow in response to metabolic s
Externí odkaz:
https://doaj.org/article/e352a5fe0b154980b79e98ee00500aab
Autor:
Mira van der Naald, Steven A J Chamuleau, Julia M L Menon, Wim de Leeuw, Judith J de Haan, Dirk J Duncker, Kimberley E Wever
Publikováno v:
PLoS Biology, Vol 19, Iss 9, p e3001397 (2021)
In 2018, the first registry dedicated to preregistration of animal study protocols was launched. Despite international support, the overall number of (pre)registered protocols is still low, illustrating the need for pushing the preregistration agenda
Externí odkaz:
https://doaj.org/article/7b4fe5d10b654104899ac79fb5e86b92
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 1, Pp 64-69 (2019)
Activation of both adenosine A2A and A2B receptors (A2BR) contributes to coronary vasodilation. We previously demonstrated that uridine adenosine tetraphosphate (Up4A) is a novel vasodilator in the porcine coronary microcirculation, acting mainly on
Externí odkaz:
https://doaj.org/article/a1130ed6bf4649d9956ef35d1e6d8e7d
Autor:
Dirk J. Duncker, Oana Sorop, Jens van de Wouw, Gao Fen, Vincent J. de Beer, Yannick J. Taverne, Henri J. D. de Graaff, Daphne Merkus
Publikováno v:
American journal of physiology. Heart and circulatory physiology, 323(6), H1080-H1090. American Physiological Society
The interplay of mechanisms regulating coronary blood flow (CBF) remains incompletely understood. Previous studies in dogs indicated that CBF regulation by KATP channels, adenosine, and nitric oxide (NO) follows a nonlinear redundancy design and full
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1f07593c9c6912d29237d522d8f23
https://doi.org/10.1152/ajpheart.00109.2021
https://doi.org/10.1152/ajpheart.00109.2021