Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Dirk Heckl"'
Autor:
Michelle Ng, Lonneke Verboon, Hasan Issa, Raj Bhayadia, Marit Willemijn Vermunt, Robert Winkler, Leah Schüler, Oriol Alejo, Konstantin Schuschel, Eniko Regenyi, Dorit Borchert, Michael Heuser, Dirk Reinhardt, Marie-Laure Yaspo, Dirk Heckl, Jan-Henning Klusmann
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107844- (2023)
Summary: The noncoding genome presents a largely untapped source of new biological insights, including thousands of long noncoding RNA (lncRNA) loci. While lncRNA dysregulation has been reported in myeloid malignancies, their functional relevance rem
Externí odkaz:
https://doaj.org/article/2ac8f8d3abed48ac804f570792af8c42
Publikováno v:
HemaSphere, Vol 7, p e76742f9 (2023)
Externí odkaz:
https://doaj.org/article/69faa97171454a889b916f895d1485b7
Autor:
Robert Winkler, Dirk Heckl, Michelle Ng, Reinier Boon, Hasan Issa, Raj Bhayadia, Jan-Henning Klusmann
Publikováno v:
HemaSphere, Vol 7, p e446889a (2023)
Externí odkaz:
https://doaj.org/article/0385288473564a408823c8c1cd12ff57
Publikováno v:
HemaSphere, Vol 7, p e9193694 (2023)
Externí odkaz:
https://doaj.org/article/f2d6bd2aa714465e89ac76e1d9ddbadf
Publikováno v:
Molecular and Cellular Pediatrics, Vol 9, Iss 1, Pp 1-9 (2022)
Abstract Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have yielded new molecular insights in
Externí odkaz:
https://doaj.org/article/4eb31c7015f64ce889708255f1d55ef5
The stem cell–specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia
Autor:
Sina Al-Kershi, Raj Bhayadia, Michelle Ng, Lonneke Verboon, Stephan Emmrich, Lucie Gack, Adrian Schwarzer, Till Strowig, Dirk Heckl, Jan-Henning Klusmann
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4252-4263 (2019)
Abstract: HOX genes are highly conserved, and their precisely controlled expression is crucial for normal hematopoiesis. Accordingly, deregulation of HOX genes can cause leukemia. However, despite of intensive research on the coding HOX genes, the ro
Externí odkaz:
https://doaj.org/article/1c4a87e290a14b1c9934a7dd5f6a96d1
Autor:
Yvonne Knopp, Franziska K. Geis, Dirk Heckl, Stefan Horn, Thomas Neumann, Johannes Kuehle, Janine Meyer, Boris Fehse, Christopher Baum, Michael Morgan, Johann Meyer, Axel Schambach, Melanie Galla
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 256-274 (2018)
The recently discovered CRISPR/Cas9 system is widely used in basic research and is a useful tool for disease modeling and gene editing therapies. However, long-term expression of DNA-modifying enzymes can be associated with cytotoxicity and is partic
Externí odkaz:
https://doaj.org/article/2595b6871a8e4673b10f1cd8093290c6
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Individuals with Down syndrome are genetically predisposed to developing acute megakaryoblastic leukemia. This myeloid leukemia associated with Down syndrome (ML–DS) demonstrates a model of step-wise leukemogenesis with perturbed hematopoiesis alre
Externí odkaz:
https://doaj.org/article/e07884162b0a44ccae34b02789140548
Autor:
Amit Sharma, Nidhi Jyotsana, Razif Gabdoulline, Dirk Heckl, Florian Kuchenbauer, Robert K. Slany, Arnold Ganser, Michael Heuser
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Mixed lineage leukemia (MLL/KMT2A) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9 and MEIS1, in human and murine MLL-rearran
Externí odkaz:
https://doaj.org/article/2c4504fcbbc6476ebb3bdac800d86d4d
Autor:
Adrian Schwarzer, Stephan Emmrich, Franziska Schmidt, Dominik Beck, Michelle Ng, Christina Reimer, Felix Ferdinand Adams, Sarah Grasedieck, Damian Witte, Sebastian Käbler, Jason W. H. Wong, Anushi Shah, Yizhou Huang, Razan Jammal, Aliaksandra Maroz, Mojca Jongen-Lavrencic, Axel Schambach, Florian Kuchenbauer, John E. Pimanda, Dirk Reinhardt, Dirk Heckl, Jan-Henning Klusmann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
While micro-RNAs are known regulators of haematopoiesis and leukemogenesis, the role of long non-coding RNAs is less clear. Here the authors provide a non-coding RNA expression landscape of the human hematopoietic system, highlighting their role in t
Externí odkaz:
https://doaj.org/article/ecded43fcdb64f949d09ac6436b134eb