Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dirk H Siepe"'
Autor:
Dirk H Siepe, Lukas T Henneberg, Steven C Wilson, Gaelen T Hess, Michael C Bassik, Kai Zinn, K Christopher Garcia
Publikováno v:
eLife, Vol 11 (2022)
Secreted proteins, which include cytokines, hormones, and growth factors, are extracellular ligands that control key signaling pathways mediating cell-cell communication within and between tissues and organs. Many drugs target secreted ligands and th
Externí odkaz:
https://doaj.org/article/90ea4d2824bf4511ac733cb205b973f5
In recent years, targeted protein degradation (TPD) of plasma membrane proteins by hijacking the ubiquitin proteasome system (UPS) or the lysosomal pathway have emerged as novel therapeutic avenues in drug development to address and inhibit canonical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a24eeaa9f9988c7405198d5f9697dcb
https://doi.org/10.1101/2022.10.31.514624
https://doi.org/10.1101/2022.10.31.514624
Autor:
John Janetzko, Ryoji Kise, Benjamin Barsi‐Rhyne, Dirk H. Siepe, Franziska M. Heydenreich, Matthieu Masureel, Kouki Kawakami, K. C. Garcia, Mark Zastrow, Asuka Inoue, Brian K. Kobilka
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61af36971992f108e0a5ac3ee1f54248
https://doi.org/10.1096/fasebj.2022.36.s1.r6320
https://doi.org/10.1096/fasebj.2022.36.s1.r6320
Autor:
John Janetzko, Ryoji Kise, Benjamin Barsi-Rhyne, Dirk H. Siepe, Franziska M. Heydenreich, Kouki Kawakami, Matthieu Masureel, Shoji Maeda, K. Christopher Garcia, Mark von Zastrow, Asuka Inoue, Brian K. Kobilka
Publikováno v:
Cell
Binding of arrestin to phosphorylated G protein-coupled receptors (GPCRs) is crucial for modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins, while others interact only transiently; this difference affects GPCR sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0080dd89b74624622aa3a8a342956a