Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Dirk G de Rooij"'
Autor:
Natalia Felipe-Medina, Sandrine Caburet, Fernando Sánchez-Sáez, Yazmine B Condezo, Dirk G de Rooij, Laura Gómez-H, Rodrigo Garcia-Valiente, Anne Laure Todeschini, Paloma Duque, Manuel Adolfo Sánchez-Martin, Stavit A Shalev, Elena Llano, Reiner A Veitia, Alberto M Pendás
Publikováno v:
eLife, Vol 9 (2020)
Primary Ovarian Insufficiency (POI) is a major cause of infertility, but its etiology remains poorly understood. Using whole-exome sequencing in a family with three cases of POI, we identified the candidate missense variant S167L in HSF2BP, an essent
Externí odkaz:
https://doaj.org/article/26db10f852a84974ae97f713af8a613d
Autor:
Maria M Mikedis, Yuting Fan, Peter K Nicholls, Tsutomu Endo, Emily K Jackson, Sarah A Cobb, Dirk G de Rooij, David C Page
Publikováno v:
eLife, Vol 9 (2020)
Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined w
Externí odkaz:
https://doaj.org/article/2312dd28ddac47b695b92a14710794bd
Autor:
Megan A Gura, Maria M Mikedis, Kimberly A Seymour, Dirk G de Rooij, David C Page, Richard N Freiman
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008515 (2020)
Germ cells undergo many developmental transitions before ultimately becoming either eggs or sperm, and during embryonic development these transitions include epigenetic reprogramming, quiescence, and meiosis. To begin understanding the transcriptiona
Externí odkaz:
https://doaj.org/article/621760bfc3a2474c9061383b9789fb7a
Autor:
Laura Gómez-H, Natalia Felipe-Medina, Yazmine B Condezo, Rodrigo Garcia-Valiente, Isabel Ramos, José Angel Suja, José Luis Barbero, Ignasi Roig, Manuel Sánchez-Martín, Dirk G de Rooij, Elena Llano, Alberto M Pendas
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008316 (2019)
The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. In mammals, the pr
Externí odkaz:
https://doaj.org/article/84914a7598074ee385fc28b2784651a2
Publikováno v:
eLife, Vol 8 (2019)
The germ line provides the cellular link between generations of multicellular organisms, its cells entering the meiotic cell cycle only once each generation. However, the mechanisms governing this initiation of meiosis remain poorly understood. Here,
Externí odkaz:
https://doaj.org/article/c5375aede47b4eeba12f1cea69233681
Autor:
Alexis S Bailey, Pedro J Batista, Rebecca S Gold, Y Grace Chen, Dirk G de Rooij, Howard Y Chang, Margaret T Fuller
Publikováno v:
eLife, Vol 6 (2017)
The switch from mitosis to meiosis is the key event marking onset of differentiation in the germline stem cell lineage. In Drosophila, the translational repressor Bgcn is required for spermatogonia to stop mitosis and transition to meiotic prophase a
Externí odkaz:
https://doaj.org/article/c1bb0fbf955f4358a4ae2280819dbc35
Autor:
Y Q Shirleen Soh, Maria M Mikedis, Mina Kojima, Alexander K Godfrey, Dirk G de Rooij, David C Page
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006704 (2017)
The meiosis-specific chromosomal events of homolog pairing, synapsis, and recombination occur over an extended meiotic prophase I that is many times longer than prophase of mitosis. Here we show that, in mice, maintenance of an extended meiotic proph
Externí odkaz:
https://doaj.org/article/d3d9eaae61064bb9bce366404b6f56be
Autor:
Nadege Vernet, Shantha K Mahadevaiah, Fanny Decarpentrie, Guy Longepied, Dirk G de Rooij, Paul S Burgoyne, Michael J Mitchell
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145398 (2016)
A previous study indicated that genetic information encoded on the mouse Y chromosome short arm (Yp) is required for efficient completion of the second meiotic division (that generates haploid round spermatids), restructuring of the sperm head, and d
Externí odkaz:
https://doaj.org/article/c8cef4fe7d39456f85ddb9d4a3ba2d14
Autor:
Hye-Won Song, Anilkumar Bettegowda, Daniel Oliver, Wei Yan, Mimi H Phan, Dirk G de Rooij, Mark A Corbett, Miles F Wilkinson
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118549 (2015)
RNA interference (RNAi) is widely used to determine the function of genes. We chose this approach to assess the collective function of the highly related reproductive homeobox 3 (Rhox3) gene paralogs. Using a Rhox3 short hairpin (sh) RNA with 100% co
Externí odkaz:
https://doaj.org/article/73370c86494f44caa7cd55fcfbf2fd02
Autor:
Mengcheng Luo, Jian Zhou, N Adrian Leu, Carla M Abreu, Jianle Wang, Montserrat C Anguera, Dirk G de Rooij, Maria Jasin, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004954 (2015)
Polycomb group proteins mediate transcriptional silencing in diverse developmental processes. Sex chromosomes undergo chromosome-wide transcription silencing during male meiosis. Here we report that mouse SCML2 (Sex comb on midleg-like 2), an X chrom
Externí odkaz:
https://doaj.org/article/621c5b5e66ee41edb4a88fdf68d700cc