Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Dirk Fey"'
Autor:
Katharina F. Heil, Anze Zupanic, Chris T. Evelo, Carole Goble, Kristel Van Steen, Tadeja Rezen, Hans V Westerhoff, Rahuman S. Malik Sheriff, Maria Suarez Diez, Henning Hermjakob, Marco Pagni, Damjana Rozman, Barbara Szomolay, Miguel Rocha, Jasper Koehorst, Alexey Kolodkin, Victoria Dominguez Del Angel, David Šafránek, Dirk Fey, Ilja Arts, Rui Benfeitas, Vitor Martins dos Santos, Mihail Anton, Marek Ostaszewski, Ulrike Wittig, John M. Hancock, Brane Leskošek, Katherine Wolstencroft, Martin Golebiewski, Wolfgang Müller, Polonca Ferk, Kristina Gruden, William T. Scott, Elena Domínguez-Romero, Martina Kutmon, Maria I. Klapa, Sébastien Moretti, Pascal Kahlem
Publikováno v:
F1000Research, Vol 11 (2024)
In this white paper, we describe the founding of a new ELIXIR Community - the Systems Biology Community - and its proposed future contributions to both ELIXIR and the broader community of systems biologists in Europe and worldwide. The Community beli
Externí odkaz:
https://doaj.org/article/231bbdc173f041d7b339528a06d2b5e4
Autor:
Katharina F. Heil, Anze Zupanic, Chris T. Evelo, Carole Goble, Kristel Van Steen, Tadeja Rezen, Hans V Westerhoff, Rahuman S. Malik Sheriff, Maria Suarez Diez, Henning Hermjakob, Marco Pagni, Damjana Rozman, Barbara Szomolay, Miguel Rocha, Jasper Koehorst, Alexey Kolodkin, Victoria Dominguez Del Angel, David Šafránek, Dirk Fey, Ilja Arts, Rui Benfeitas, Vitor Martins dos Santos, Mihail Anton, Marek Ostaszewski, Ulrike Wittig, John M. Hancock, Brane Leskošek, Katherine Wolstencroft, Martin Golebiewski, Wolfgang Müller, Polonca Ferk, Kristina Gruden, Martina Kutmon, Maria I. Klapa, Sébastien Moretti, Pascal Kahlem
Publikováno v:
F1000Research, Vol 11 (2022)
In this white paper, we describe the founding of a new ELIXIR Community - the Systems Biology Community - and its proposed future contributions to both ELIXIR and the broader community of systems biologists in Europe and worldwide. The Community beli
Externí odkaz:
https://doaj.org/article/da5bfc6068504a22a6da45f585378940
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The initiation of apoptosis is a core mechanism in cellular biology by which organisms control the removal of damaged or unnecessary cells. The irreversible activation of caspases is essential for apoptosis, and mathematical models have demo
Externí odkaz:
https://doaj.org/article/0aa6015556d4479ab8ffa900097c7e38
Autor:
Vít Nováček, Gavin McGauran, David Matallanas, Adrián Vallejo Blanco, Piero Conca, Emir Muñoz, Luca Costabello, Kamalesh Kanakaraj, Zeeshan Nawaz, Brian Walsh, Sameh K Mohamed, Pierre-Yves Vandenbussche, Colm J Ryan, Walter Kolch, Dirk Fey
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1007578 (2020)
Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular processes. However, discovering specific kinase-substrate relationships is time-consuming and often rather serendipi
Externí odkaz:
https://doaj.org/article/25d2415552804e8fa21e45dbf2bf6550
Autor:
Annabelle Nwaokorie, Dirk Fey
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9970 (2021)
Gaining insight into the mechanisms of signal transduction networks (STNs) by using critical features from patient-specific mathematical models can improve patient stratification and help to identify potential drug targets. To achieve this, these mod
Externí odkaz:
https://doaj.org/article/a37aef430b8c4b35b0ca333dd0df1c76
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-9 (2017)
Systems biology: Performance of parameter estimation procedures A systematic comparison of critical choices for faithful parameter-estimation identifies a combination of a hybrid optimisation algorithm (GLSDC) with data-driven normalisation of simula
Externí odkaz:
https://doaj.org/article/f39d9d389cf242828144b415430ae66d
Autor:
Hyunryul Ryu, Minhwan Chung, Maciej Dobrzyński, Dirk Fey, Yannick Blum, Sung Sik Lee, Matthias Peter, Boris N Kholodenko, Noo Li Jeon, Olivier Pertz
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp n/a-n/a (2016)
Externí odkaz:
https://doaj.org/article/7353e927188549d0889c7d2e5e6ed064
Autor:
Jordan F. Hastings, Sharissa L. Latham, Alvin Kamili, Madeleine S. Wheatley, Jeremy Z. R. Han, Marie Wong-Erasmus, Monica Phimmachanh, Max Nobis, Chiara Pantarelli, Antonia L. Cadell, Yolande E. I. O’Donnell, King Ho Leong, Sophie Lynn, Fan-Suo Geng, Lujing Cui, Sabrina Yan, Joanna Achinger-Kawecka, Clare Stirzaker, Murray D. Norris, Michelle Haber, Toby N. Trahair, Frank Speleman, Katleen De Preter, Mark J. Cowley, Ozren Bogdanovic, Paul Timpson, Thomas R. Cox, Walter Kolch, Jamie I. Fletcher, Dirk Fey, David R. Croucher
Publikováno v:
SCIENCE ADVANCES
Gene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare cancer cells. However, we now demonstrate that chemoresistant neuroblastoma cells emerge at a much higher frequency when
Autor:
Nupur Mukherjee, Alacoque Browne, Laura Ivers, Tapesh Santra, Mattia Cremona, Bryan T. Hennessy, Norma O’Donovan, John Crown, Walter Kolch, Dirk Fey, Alex J. Eustace
Publikováno v:
Journal of Personalized Medicine; Volume 12; Issue 8; Pages: 1277
Triple negative breast cancer (TNBC) remains a therapeutic challenge due to the lack of targetable genetic alterations and the frequent development of resistance to the standard cisplatin-based chemotherapies. Here, we have taken a systems biology ap