Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Dirk Eick"'
Autor:
Tim-Michael Decker, Michael Kluge, Stefan Krebs, Nilay Shah, Helmut Blum, Caroline C. Friedel, Dirk Eick
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The bromodomain protein Brd4 is an epigenetic reader and plays a critical role in the development and maintenance of leukemia. Brd4 binds to acetylated histone tails and activates transcription by recruiting the positive elongation factor P-
Externí odkaz:
https://doaj.org/article/ba77fcb301da4351a857a418f3d765e0
Autor:
Dirk Eick
Publikováno v:
eLife, Vol 7 (2018)
The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
Externí odkaz:
https://doaj.org/article/8caffe359d554e03a29bd7556f4bb46d
Autor:
Saskia Gressel, Björn Schwalb, Tim Michael Decker, Weihua Qin, Heinrich Leonhardt, Dirk Eick, Patrick Cramer
Publikováno v:
eLife, Vol 6 (2017)
Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a ‘multi-omics’ approach to demonstrate that the duration of polyme
Externí odkaz:
https://doaj.org/article/241f4cf38a0d4bc59056a943842a6b8c
Autor:
Nicolas Descostes, Martin Heidemann, Lionel Spinelli, Roland Schüller, Muhammad Ahmad Maqbool, Romain Fenouil, Frederic Koch, Charlène Innocenti, Marta Gut, Ivo Gut, Dirk Eick, Jean-Christophe Andrau
Publikováno v:
eLife, Vol 3 (2014)
In mammals, the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II consists of 52 conserved heptapeptide repeats containing the consensus sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Post-translational modifications of the CTD coordinate the tr
Externí odkaz:
https://doaj.org/article/56988b85933f4d25b9e33e45db564b68
Autor:
Steven A. Johnsen, Tim Beissbarth, Mikael Simons, Elisabeth Kremmer, Dirk Eick, Corinna Hintermair, Theresa Gorsler, Chieh Hsu, Magali Hennion, Frank Kramer, Yvonne Begus-Nahrmann, Tanja Prenzel
PDf file - 174K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bf3d569986240a4b0768dba9ac0ae0
https://doi.org/10.1158/0008-5472.22389308.v1
https://doi.org/10.1158/0008-5472.22389308.v1
Autor:
Steven A. Johnsen, Tim Beissbarth, Mikael Simons, Elisabeth Kremmer, Dirk Eick, Corinna Hintermair, Theresa Gorsler, Chieh Hsu, Magali Hennion, Frank Kramer, Yvonne Begus-Nahrmann, Tanja Prenzel
PDF file - 1.1MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7490f0f79be4e495269e4fc157bf0e96
https://doi.org/10.1158/0008-5472.22389311.v1
https://doi.org/10.1158/0008-5472.22389311.v1
Autor:
Nilay Shah, Hesham Elsaman, Guoli Ma, Tobias Straub, Dirk Eick, Tim-Michael Decker, Ignasi Forné, Axel Imhof
Publikováno v:
Oncotarget
Oncotarget 10, 6934-6943 (2019)
Oncotarget 10, 6934-6943 (2019)
// Tim-Michael Decker 1 , 4 , Ignasi Forne 2 , Tobias Straub 3 , Hesham Elsaman 1 , Guoli Ma 1 , Nilay Shah 1 , 5 , Axel Imhof 2 and Dirk Eick 1 1 Department of Molecular Epigenetics, Helmholtz Center Munich and Center for Integrated Protein Science
Autor:
Corinna Hintermair, Yi-Hsuan Ho, Rajesh Kumar Kar, Corey M. Nemec, Asfa Ali, Sohail Akhtar, Aseem Z. Ansari, Dirk Eick, Audrey P. Gasch, Sandra C. Tseng, Kennedy J Ringelberg, Mohammad Faiz Ahmad, Amit Kumar Singh, Kirtimaan Syal
Publikováno v:
Nature chemical biology
Nat. Chem. Biol. 15, 123–131 (2019)
Nat. Chem. Biol. 15, 123–131 (2019)
Phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) governs stage-specific interactions with different cellular machines. The CTD consists of Y1S2P3T4S5P6S7 heptad repeats, and sequential phospho
Autor:
Michael Kluge, Caroline C. Friedel, Axel Imhof, Stefan Krebs, Ann Katrin Greifenberg, Muhammad Ahmad Maqbool, Yousra Yahia, Ignasi Forné, Nicolas Descostes, Jean-Christophe Andrau, Dirk Eick, Michaela Rohrmoser, Matthias Geyer, Anita Gruber-Eber, Helmut Blum
Publikováno v:
Nucleic Acids Research
Nucleic Acids Res. 47, 700-715 (2019)
Nucleic Acids Res. 47, 700-715 (2019)
Mammalian-wide interspersed repeats (MIRs) are retrotransposed elements of mammalian genomes. Here, we report the specific binding of zinc finger protein ZNF768 to the sequence motif GCTGTGTG (N20) CCTCTCTG in the core region of MIRs. ZNF768 binding
Autor:
François Le Dily, Narcis Fernandez Fuentes, Miguel Beato, Javier Quilez, Jose Carbonell Caballero, Dirk Eick, Priyanka Sharma, Chiara Di Vona, Roni H. G. Wright, Baldomero Oliva, Antonios Lioutas, Roland Schüller
Publikováno v:
Mol. Cell 73, 84-96 (2018)
HighlightsPeptidyl arginine deiminase 2 (PADI2) citrullinates arginine1810 (cit1810) present at carboxy-terminal domain of RNA polymerase II (RNAP2-CTD).PADI2 and R1810 of RNAP2-CTD regulate transcription and proliferation of breast cancer cells.Abse