Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Dirk Bumann"'
Autor:
Pascal Forrer, Darya Palianina, Claudia Stühler, Matthias Kreuzaler, Julien Roux, Jiagui Li, Christoph Schmutz, David Burckhardt, Fabian Franzeck, Daniela Finke, Alexander Schmidt, Dirk Bumann, Nina Khanna
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionGram-negative bacillary bacteremia poses a significant threat, ranking among the most severe infectious diseases capable of triggering life-threatening sepsis. Despite the unambiguous involvement of neutrophils in this potentially fatal d
Externí odkaz:
https://doaj.org/article/f248e605f0424033abfa4c81039890fc
Publikováno v:
Royal Society Open Science, Vol 11, Iss 4 (2024)
For a profound understanding of antagonistic coevolution, it is necessary to identify the coevolving genes. The bacterium Pasteuria and its host, the microcrustacean Daphnia, are a well-characterized paradigm for co-evolution, but the underlying gene
Externí odkaz:
https://doaj.org/article/a73beef178884947b7e9bae913fc5d8e
Autor:
Alexandre Luscher, Véronique Gasser, Dirk Bumann, Gaëtan L. A. Mislin, Isabelle J. Schalk, Thilo Köhler
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen responsible for acute and chronic infections in immunocompromised hosts. This organism is known to compete efficiently against coinfecting microorganisms, due in part to the secretion of an
Externí odkaz:
https://doaj.org/article/a7fc5dda6dda4e04972664a33eda9ab5
Autor:
Patrick Hauswirth, Jonas Buck, Ramya Puligilla, Claudio Luca Alter, Sandro Sieber, Beatrice Claudi, Joseph Fanous, Dirk Bumann, Jörg Huwyler
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 5, p 99 (2023)
Introduction: Blood infections from multi-drug-resistant Salmonella pose a major health burden. This is especially true because Salmonella can survive and replicate intracellularly, and the development of new treatment strategies is dependent on expe
Externí odkaz:
https://doaj.org/article/0c7e1f50b348432794061c38b095f880
Publikováno v:
BMC Microbiology, Vol 20, Iss 1, Pp 1-6 (2020)
Abstract Background Gene editing is key for elucidating gene function. Traditional methods, such as consecutive single-crossovers, have been widely used to modify bacterial genomes. However, cumbersome cloning and limited efficiency of negative selec
Externí odkaz:
https://doaj.org/article/e1d87fe616d84149a8a7b465bc4f888b
Autor:
Satya Prathyusha Bhamidimarri, Tessa R Young, Muralidharan Shanmugam, Sandra Soderholm, Arnaud Baslé, Dirk Bumann, Bert van den Berg
Publikováno v:
PLoS Biology, Vol 19, Iss 11, p e3001446 (2021)
Copper, while toxic in excess, is an essential micronutrient in all kingdoms of life due to its essential role in the structure and function of many proteins. Proteins mediating ionic copper import have been characterised in detail for eukaryotes, bu
Externí odkaz:
https://doaj.org/article/af8157dec86e4154a2b6cbf9055eb196
Autor:
David Haschka, Piotr Tymoszuk, Verena Petzer, Richard Hilbe, Simon Heeke, Stefanie Dichtl, Sergej Skvortsov, Egon Demetz, Sylvia Berger, Markus Seifert, Anna-Maria Mitterstiller, Patrizia Moser, Dirk Bumann, Manfred Nairz, Igor Theurl, Guenter Weiss
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Iron is an essential nutrient for mammals as well as for pathogens. Inflammation-driven changes in systemic and cellular iron homeostasis are central for host-mediated antimicrobial strategies. Here, we studied the role of the iron storage protein fe
Externí odkaz:
https://doaj.org/article/209b2aeb2249437fa007338aa127d5eb
Autor:
Ruchika Dehinwal, Danielle Cooley, Alexey V. Rakov, Akhil S. Alugupalli, Joey Harmon, Olivier Cunrath, Prashanth Vallabhajosyula, Dirk Bumann, Dieter M. Schifferli
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Bacterial outer membrane vesicles (OMVs) mediate critical bacterium-bacterium and host-microbial interactions that influence pathogenesis through multiple mechanisms, including the elicitation of inflammatory responses, delivery of virulence factors,
Externí odkaz:
https://doaj.org/article/5cda3a57d9994e359b660a611990399a
Autor:
Olivier Cunrath, Dominik M. Meinel, Pauline Maturana, Joseph Fanous, Julien M. Buyck, Pamela Saint Auguste, Helena M.B. Seth-Smith, Jonas Körner, Christoph Dehio, Vincent Trebosc, Christian Kemmer, Richard Neher, Adrian Egli, Dirk Bumann
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 479-487 (2019)
Background: Efflux pumps mediate antimicrobial resistance in several WHO critical priority bacterial pathogens. However, most available data come from laboratory strains. The quantitative relevance of efflux in more relevant clinical isolates remains
Externí odkaz:
https://doaj.org/article/83adf038018a43549d6ed8f1a82d4214
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Altered lipid metabolism in macrophages is associated with various important inflammatory conditions. Although lipid metabolism is an important target for therapeutic intervention, the metabolic requirement involved in lipid accumulation during pro-i
Externí odkaz:
https://doaj.org/article/321ec069674b4a23b5d6615ab65f87e2