Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Dirk Bartnik"'
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Akademický článek
Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination.
Autor: Antonia Nicole Klein, Tamar Ziehm, Markus Tusche, Johan Buitenhuis, Dirk Bartnik, Annett Boeddrich, Thomas Wiglenda, Erich Wanker, Susanne Aileen Funke, Oleksandr Brener, Lothar Gremer, Janine Kutzsche, Dieter Willbold
Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153035 (2016)
The aggregation of amyloid-β (Aβ) is postulated to be the crucial event in Alzheimer's disease (AD). In particular, small neurotoxic Aβ oligomers are considered to be responsible for the development and progression of AD. Therefore, elimination of
Externí odkaz: https://doaj.org/article/083680e70c82443787f8e0d46841487d
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2
Akademický článek
Development of a small D-enantiomeric Alzheimer's amyloid-β binding peptide ligand for future in vivo imaging applications.
Autor: Susanne Aileen Funke, Dirk Bartnik, Julian Marius Glück, Kasia Piorkowska, Katja Wiesehan, Urs Weber, Balazs Gulyas, Christer Halldin, Andrea Pfeifer, Christian Spenger, Andreas Muhs, Dieter Willbold
Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41457 (2012)
Alzheimer's disease (AD) is a devastating disease affecting predominantly the aging population. One of the characteristic pathological hallmarks of AD are neuritic plaques, consisting of amyloid-β peptide (Aβ). While there has been some advancement
Externí odkaz: https://doaj.org/article/ce9a1aae78d8452baa52b21d0c56408f
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3
A synthetic amino acid substitution of Tyr10 in Aβ peptide sequence yields a dominant negative variant in amyloidogenesis
Autor: Christian Lévêque, Jacques Fantini, Dirk Bartnik, Mariarosa A. B. Melone, Honoree Mazargui, Tiphany Gouget, Dieter Willbold, Susanne Aileen Funke, Lorena Perrone
Publikováno v: Aging Cell. 11:530-541
Alzheimer's disease (AD) is the most common cause of dementia in elderly people, and age is the major nongenetic risk factor for sporadic AD. A hallmark of AD is the accumulation of amyloid in the brain, which is composed mainly of the amyloid beta-p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42aaf681e75bf2449728c0fa82e4eedd
https://doi.org/10.1111/j.1474-9726.2012.00814.x
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5
Oral Treatment with the d-Enantiomeric Peptide D3 Improves the Pathology and Behavior of Alzheimer’s Disease Transgenic Mice
Autor: Dirk Bartnik, Luitgard Nagel-Steger, Andreas Müller-Schiffmann, Carsten Korth, Renu Batra-Safferling, Inga Kadish, Torsten Sehl, Christine Moriscot, Oleksandr Brener, Thomas van Groen, Heinrich Sticht, Dieter Willbold, Guy Schoehn, Susanne Aileen Funke, Anselm H. C. Horn
Publikováno v: ACS Chemical Neuroscience. 1:639-648
Several lines of evidence suggest that the amyloid-β-peptide (Aβ) plays a central role in the pathogenesis of Alzheimer's disease (AD). Not only Aβ fibrils but also small soluble Aβ oligomers in particular are suspected to be the major toxic spec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cfa9582d6a69b371e82d2ae2a3b14d
https://doi.org/10.1021/cn100057j
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7
Treatment of D3 removes amyloid deposits, reduces inflammation, and improves cognition in aged APP/PS1 double transgenic mice
Autor: Dieter Willbold, Dirk Bartnik, Susanne Aileen Funke, Thomas van Groen, Inga Kadish
Publikováno v: Alzheimer disease & associated disorders 34(3), 609-620 (2013). doi:10.3233/JAD-121792
One of the characteristic pathological hallmarks of Alzheimer's disease (AD) is neuritic plaques. The sequence of events leading to deposition of amyloid-β (Aβ) peptides in plaques is not clear. Here we investigate the effects of D3, an Aβ oligome
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96968dcfab843a4cb79e7babe41b25c1
https://juser.fz-juelich.de/record/133637
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8
Treatment with Aβ42 binding D-amino acid peptides reduce amyloid deposition and inflammation in APP/PS1 double transgenic mice
Autor: Thomas, van Groen, Inga, Kadish, Aileen, Funke, Dirk, Bartnik, Dieter, Willbold
Publikováno v: Advances in protein chemistry and structural biology. 88
One of the two characteristic pathological hallmarks of Alzheimer's disease (AD) are neuritic plaques. The sequence of events leading to the extracellular deposition of amyloid β (Aβ) peptides in plaques or in diffuse deposits is not clear. Here we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5b10598756b873872bd7cfd1ec33883
https://pubmed.ncbi.nlm.nih.gov/22814708
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9
Treatment with Aβ42 Binding d-Amino Acid Peptides Reduce Amyloid Deposition and Inflammation in APP/PS1 Double Transgenic Mice
Autor: Inga Kadish, Aileen Funke, Dirk Bartnik, Thomas van Groen, Dieter Willbold
One of the two characteristic pathological hallmarks of Alzheimer's disease (AD) are neuritic plaques. The sequence of events leading to the extracellular deposition of amyloid β (Aβ) peptides in plaques or in diffuse deposits is not clear. Here we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8178374a1e9a9db1ed7c96b5c374e74d
https://doi.org/10.1016/b978-0-12-398314-5.00005-2
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10
Development of a small D-enantiomeric Alzheimer's amyloid-β binding peptide ligand for future in vivo imaging applications
Autor: Dieter Willbold, Susanne Aileen Funke, Kasia Piorkowska, Andreas Muhs, Andrea Pfeifer, Urs Weber, Christian Spenger, Balázs Gulyás, Christer Halldin, Katja Wiesehan, Dirk Bartnik, Julian Glück
Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41457 (2012)
PLoS one 7(7), e41457 (2012). doi:10.1371/journal.pone.0041457
PLoS ONE
Alzheimer's disease (AD) is a devastating disease affecting predominantly the aging population. One of the characteristic pathological hallmarks of AD are neuritic plaques, consisting of amyloid-beta peptide (A beta). While there has been some advanc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc681e976b0465b7f80e8842ef756f9
http://europepmc.org/articles/PMC3404088?pdf=render
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