Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Dirk A. Lamprecht"'
Autor:
Jody Phelan, Klaas Van den Heede, Serge Masyn, Rudi Verbeeck, Dirk A. Lamprecht, Anil Koul, Richard J. Wall
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Tuberculosis (TB) remains one of the leading infectious disease killers in the world. The ongoing development of novel anti-TB medications has yielded potent compounds that often target single sites with well-defined mechanisms of action. Ho
Externí odkaz:
https://doaj.org/article/b4491d1e934544a5b1737f5ab702eac6
Autor:
Jared S. Mackenzie, Dirk A. Lamprecht, Rukaya Asmal, John H. Adamson, Khushboo Borah, Dany J. V. Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna Krieger, James C. Sacchettini, Joel N. Glasgow, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Bedaquiline (BDQ) is a known tuberculosis treatment, but the precise mechanism of cell death is unclear. Here, the authors explore the metabolic profiles of M. tuberculosis upon BDQ treatment and find reliance on glycolysis and synergistic cell death
Externí odkaz:
https://doaj.org/article/d680f868a7c742a69cdc3f6e9206d15b
Autor:
Vikram Saini, Krishna C. Chinta, Vineel P. Reddy, Joel N. Glasgow, Asaf Stein, Dirk A. Lamprecht, Md. Aejazur Rahman, Jared S. Mackenzie, Barry E. Truebody, John H. Adamson, Tafara T. R. Kunota, Shannon M. Bailey, Douglas R. Moellering, Jack R. Lancaster, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The importance of host-produced hydrogen sulfide (H2S) in microbial pathogenesis is poorly understood. Here, Saini et al. show that H2S alters Mycobacterium tuberculosis (Mtb) central metabolism, stimulates respiration to promote growth and TB diseas
Externí odkaz:
https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
Autor:
Shannon L. Russell, Dirk A. Lamprecht, Tawanda Mandizvo, Terrence T. Jones, Vanessa Naidoo, Kelvin W. Addicott, Chivonne Moodley, Bongani Ngcobo, David K. Crossman, Gordon Wells, Adrie J.C. Steyn
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3564-3579.e5 (2019)
Summary: The immunometabolic mechanisms underlying suboptimal T cell immunity in tuberculosis remain undefined. Here, we examine how chronic Mycobacterium tuberculosis (Mtb) and M. bovis BCG infections rewire metabolic circuits and alter effector fun
Externí odkaz:
https://doaj.org/article/da8c623993154564bb91cd0cae3fa819
Autor:
Tafara T. R. Kunota, Md. Aejazur Rahman, Barry E. Truebody, Jared S. Mackenzie, Vikram Saini, Dirk A. Lamprecht, John H. Adamson, Ritesh R. Sevalkar, Jack R. Lancaster, Michael Berney, Joel N. Glasgow, Adrie J. C. Steyn
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1285 (2021)
H2S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H2S has been shown to profoundly alter M. tuberculosis (Mtb) energy metabolism and growth. However, compelling evidence for endogenous production of H2S and its role in Mtb phys
Externí odkaz:
https://doaj.org/article/fec3048b30624ab090468cbae2579f5b
Autor:
Dirk A. Lamprecht, Peter M. Finin, Md. Aejazur Rahman, Bridgette M. Cumming, Shannon L. Russell, Surendranadha R. Jonnala, John H. Adamson, Adrie J. C. Steyn
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Several inhibitors of the electron transport chain (ETC) are active against Mycobacterium tuberculosis. Here, Lamprecht et al. show that a combination of known inhibitors (bedaquiline, Q203 and clofazimine) displays synergistic effects on the M. tube
Externí odkaz:
https://doaj.org/article/9a86dfe38a8246cd9d09bf2f836eeae4
Autor:
Vikram Saini, Bridgette M. Cumming, Loni Guidry, Dirk A. Lamprecht, John H. Adamson, Vineel P. Reddy, Krishna C. Chinta, James H. Mazorodze, Joel N. Glasgow, Melissa Richard-Greenblatt, Anaximandro Gomez-Velasco, Horacio Bach, Yossef Av-Gay, Hyungjin Eoh, Kyu Rhee, Adrie J.C. Steyn
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 572-585 (2016)
The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox bu
Externí odkaz:
https://doaj.org/article/e86030a4d9474eae8ff100fea63540c3
Autor:
Caroline S. Foo, Andréanne Lupien, Maryline Kienle, Anthony Vocat, Andrej Benjak, Raphael Sommer, Dirk A. Lamprecht, Adrie J. C. Steyn, Kevin Pethe, Jérémie Piton, Karl-Heinz Altmann, Stewart T. Cole
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with Mycobacterium tuberculosis. We report here on our work with AX-35, an arylvinylpiperazine amide, and four related analogs, which are potent antit
Externí odkaz:
https://doaj.org/article/adb9ac67e2c14c6b855d0f2b8719a48c
Publikováno v:
Southern African Journal of HIV Medicine, Volume: 24, Issue: 1, Pages: 1-9, Published: 2023
Background: HIV and AIDS continues to impose substantial healthcare challenges in sub-Saharan Africa, but there are limited local data comparing inpatient outcomes between people with HIV (PLWH) and those uninfected.Objectives: To compare cause-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fcc64a682d4e65e02e50f292b6c6de
https://doi.org/10.4102/sajhivmed.v24i1.1477
https://doi.org/10.4102/sajhivmed.v24i1.1477
Autor:
Asaf Stein, Jack R. Lancaster, Tafara T.R. Kunota, Shannon M. Bailey, Jared S. Mackenzie, Dirk A. Lamprecht, Adrie J. C. Steyn, Vineel P. Reddy, Krishna C. Chinta, Vikram Saini, Barry E. Truebody, Douglas R. Moellering, Md. Aejazur Rahman, John H. Adamson, Joel N. Glasgow
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Hydrogen sulfide (H2S) is involved in numerous pathophysiological processes and shares overlapping functions with CO and •NO. However, the importance of host-derived H2S in microbial pathogenesis is unknown. Here we show that Mtb-infected mice defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa427814c223c5b5ff6ca38726388540
https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3
https://doaj.org/article/20fabbdfe15b499283f6565afa5077d3