Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Dirk A, Heerding"'
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Methods and Figure Legends 1-2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a3405f44d49aec54206ba52ba0d265
https://doi.org/10.1158/0008-5472.22370963
https://doi.org/10.1158/0008-5472.22370963
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Figure 2 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426e3e38118b83488267a117b29c53cd
https://doi.org/10.1158/0008-5472.22370966
https://doi.org/10.1158/0008-5472.22370966
Autor:
Rakesh Kumar, Robert A. Copeland, Pearl S. Huang, Edgar R. Wood, Susan L. Strum, Elisabeth A. Minthorn, Jack D. Leber, Zhihong Lai, Anthony E. Choudhry, Elena V. Kleymenova, Robert S. Geske, Jason A. Kahana, Kimberly Robell, Shu-Yun Zhang, Tona M. Gilmer, Randy T. McConnell, Timothy J. Lansing, Victoria B. Knick, Derek J. Eberwein, Derek R. Duckett, Dirk A. Heerding, Nelson Rhodes
Supplementary Figure 1 from Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4abec9d184e4e3594165c4dd227e1f2
https://doi.org/10.1158/0008-5472.22370972.v1
https://doi.org/10.1158/0008-5472.22370972.v1
Autor:
Christopher L. Carpenter, Eldridge N. Nartey, Dominic Suarez, Elisabeth A. Minthorn, Jesus R. Medina, Louis V. LaFrance, Ralph A. Rivero, James F. Mack, Charles F. McHugh, Xinrong Tian, Dirk A. Heerding, Christina Ng Di Marco, Thomas J. Berrodin, Aishwarya Bhaskar, Biju Mangatt, William Hoi Hong Li, Brackley James, Martyr Cuthbert, Lorena A. Kallal, Michael Butticello, Jacob Rubin
Publikováno v:
Journal of Medicinal Chemistry. 64:16056-16087
Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacological inhibitors that directly target MYC have not yet yielded a drug-like molecule due to the lack of an
Autor:
Peter A. Jones, Ashley K. Wiseman, Helai P. Mohammad, Christopher S. Kershaw, Bryan W. King, Ian D. Waddell, Thau F. Ho, Stephen B. Baylin, Morris Muliaditan, Marcus Bantscheff, Elisabeth A. Minthorn, Thilo Werner, Alan P. Graves, Wendy A. Kellner, Phil Chapman, Mehul Patel, Anthony J. Jurewicz, Allan M. Jordan, Emma E. Fairweather, Rab K. Prinjha, Nino Campobasso, Anna Rutkowska, H. Christian Eberl, Ryan G. Kruger, Charles F. McHugh, Michael T. McCabe, Kristin M. Goldberg, Jon Paul Jaworski, Christopher L. Carpenter, Michael Steidel, Stuart Paul Romeril, Dirk A. Heerding, Lourdes Rueda, David T. Fosbenner, Amy N. Taylor, Jacques Briand, Shawn W. Foley, Arthur Groy, Andrew B. Benowitz, Xiaodong Cheng, Donald J. Ogilvie, Paola Grandi, Cunyu Zhang, Mei Li, Sarath Pathuri, Aidan G. Gilmartin, Christian S. Sherk, Juan I. Luengo, Mark Cockerill, Ali Raoof, Alexandra Stowell, Kathryn Keenan, Melissa B. Pappalardi, Makda Mebrahtu, Kristen Wong, Xing Zhang, Jessica L. Handler, Roger J. Butlin, John R. Horton, Susan Merrihew, Charlotte Burt, Dean E. McNulty
Publikováno v:
Nature Cancer. 2:1002-1017
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as the cytidine analogs decitabine or azacytidine, has demonstrated clinical ben
Structural Characterization of Dicyanopyridine Containing DNMT1-Selective, Non-Nucleoside Inhibitors
Autor:
John R. Horton, Sarath Pathuri, Kristen Wong, Ren Ren, Lourdes Rueda, David T. Fosbenner, Dirk A. Heerding, Michael T. McCabe, Melissa B. Pappalardi, Xing Zhang, Bryan W. King, Xiaodong Cheng
Publikováno v:
Structure
DNMT1 maintains the parental DNA methylation pattern on newly replicated hemimethylated DNA. The failure of this maintenance process causes aberrant DNA methylation that affects transcription and contributes to the development and progression of canc
Autor:
Jesús R, Medina, Xinrong, Tian, William H, Li, Dominic, Suarez, James F, Mack, Louis, LaFrance, Cuthbert, Martyr, James, Brackley, Christina, Di Marco, Ralph, Rivero, Dirk A, Heerding, Charles, McHugh, Elisabeth, Minthorn, Aishwarya, Bhaskar, Jacob, Rubin, Michael, Butticello, Christopher, Carpenter, Eldridge N, Nartey, Thomas J, Berrodin, Lorena A, Kallal, Biju, Mangatt
Publikováno v:
Journal of medicinal chemistry. 64(21)
Elevated expression of the
Autor:
Melissa Dumble, Ming-Chih Crouthamel, Shu-Yun Zhang, Michael Schaber, Dana Levy, Kimberly Robell, Qi Liu, David J Figueroa, Elisabeth A Minthorn, Mark A Seefeld, Meagan B Rouse, Sridhar K Rabindran, Dirk A Heerding, Rakesh Kumar
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100880 (2014)
Tumor cells upregulate many cell signaling pathways, with AKT being one of the key kinases to be activated in a variety of malignancies. GSK2110183 and GSK2141795 are orally bioavailable, potent inhibitors of the AKT kinases that have progressed to h
Externí odkaz:
https://doaj.org/article/332f1cf8dcff42b69e7e64f5dde37d45
Autor:
Ryan G. Kruger, Junya Qu, Dai-Shi Su, Helai P. Mohammad, Melissa B. Pappalardi, Patricia A. Elkins, Alan P. Graves, Dirk A. Heerding, William G. Bonnette, Joelle Lorraine Burgess, Juan I. Luengo, Jenny Zeng, Beth Anne Knapp-Reed, Mark J. Schulz, Alexander Joseph Reif, Jeffrey D. Carson, Raman P. Nagarajan, Caretha L. Creasy, Chuck W Blackledge, Kristen Wong, Melissa Stern, Charles F. McHugh, Hongyi Yu, Liping Wang
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report herein the discovery of isoxazole amides as potent and selective SET and MYND Domain-Containing Protein 3 (SMYD3) inhibitors. Elucidation of the structure–activity relationship of the high-throughput screening (HTS) lead
Autor:
Li Liu, Dania Haddad, Sachdev S. Sidhu, Jingsong Yang, Dirk A. Heerding, Jason Moffat, Kelly Federowicz, Yanjun Li, Satra Nim, Xiaohui Dong, Aiping Dong, Andreas Ernst, Yufeng Tong, Wei Zhang, Maria A. Sartori, Taras Makhnevych
Post-translational modification of the p53 signaling pathway plays an important role in cell cycle progression and stress-induced apoptosis. Indeed, a large body of work has shown that dysregulation of p53 and its E3 ligase MDM2 by the ubiquitin-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd465a1cf938299e96002e7f07b7c31f
https://publica.fraunhofer.de/handle/publica/254350
https://publica.fraunhofer.de/handle/publica/254350