Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Dirk Tourwé"'
Autor:
Santo Previti, Michael Desgagné, Dirk Tourwé, Florine Cavelier, Philippe Sarret, Steven Ballet
Publikováno v:
Journal of Peptide Science. 29
Chronic pain is one of the most critical health issues worldwide. Despite considerable efforts to find therapeutic alternatives, opioid drugs remain the gold standard for pain management. The administration of μ-opioid receptor (MOR) agonists is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de23a55c91276e864aef08b2cde0199d
https://doi.org/10.1002/psc.3471
https://doi.org/10.1002/psc.3471
Publikováno v:
Current Medicinal Chemistry. 27:6744-6768
The neuromedin U peptide sequence is highly conserved between various species. Neuromedin U is involved in a variety of physiological processes. It exerts its effects via two neuromedin U receptors, NMUR1 and NMUR2. These receptors are characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4c0809b774fffd083a17b591c885c9
https://doi.org/10.2174/0929867326666190916143028
https://doi.org/10.2174/0929867326666190916143028
Publikováno v:
ARKIVOC, Vol 2012, Iss 5, Pp 163-174 (2012)
Externí odkaz:
https://doaj.org/article/b50be569aed3472d872793b8954689d2
Autor:
Steven Ballet, Jolien De Neve, Frédéric Bihel, Frédéric Simonin, Dirk Tourwé, Thomas M. A. Barlow
Publikováno v:
RSC Medicinal Chemistry
RSC Medicinal Chemistry, 2021, 12 (6), pp.828-870. ⟨10.1039/D1MD00041A⟩
RSC Med Chem
RSC Medicinal Chemistry, Royal Society of Chemistry, 2021
RSC Medicinal Chemistry, 2021, 12 (6), pp.828-870. ⟨10.1039/D1MD00041A⟩
RSC Med Chem
RSC Medicinal Chemistry, Royal Society of Chemistry, 2021
One of the main challenges in contemporary medicinal chemistry is the development of safer analgesics, used in the treatment of pain. Currently, moderate to severe pain is still treated with the “gold standard” opioids whose long-term often leads
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad0b75b0fb537714b4ed95a2ea83ea0
https://hal-cnrs.archives-ouvertes.fr/hal-03435229
https://hal-cnrs.archives-ouvertes.fr/hal-03435229
Autor:
Arthur Lamouroux, Simon Gonzalez, Charlotte Martin, Yu Jing, Steven Ballet, Suwen Zhao, Dirk Tourwé, Savannah Y. Williams, Roger D. Cone, Santo Previti, Luis E. Gimenez, Kevin Van Holsbeeck, Raymond C. Stevens, Yiran Wu, Olivier Van der Poorten, Charlie Hollanders
The melanocortin receptors (MC1R-MC5R) belong to class A G-protein-coupled receptors (GPCRs) and are known to have receptor-specific roles in normal and diseased states. Selectivity for MC4R is of particular interest due to its involvement in various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5590f0bbc12873632d63e9a272c4fa0
https://doi.org/10.1021/acs.jmedchem.0c01620
https://doi.org/10.1021/acs.jmedchem.0c01620
Autor:
Simon Gonzalez, Dirk Tourwé, Philippe Sarret, Mariana Spetea, Florine Cavelier, Santo Previti, Charlotte Martin, Linda Kunze, Mélanie Vivancos, Stevany Louis, Louis Gendron, Elke Dewolf, Maria Dumitrascuta, Steven Ballet, Emilie Eiselt, Annalisa Blasiol
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (21), pp.12929-12941. ⟨10.1021/acs.jmedchem.0c01376⟩
Journal of Medicinal Chemistry, American Chemical Society, 2020, 63 (21), pp.12929-12941. ⟨10.1021/acs.jmedchem.0c01376⟩
International audience; Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid agonist tetrapeptide H-Dmt-D-Arg-Aba-β-Ala-NH 2 (KGOP01) was fused t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d847dbf764c975a594956d0282309fc
https://biblio.vub.ac.be/vubir/optimized-opioidneurotensin-multitarget-peptides-from-design-to-structureactivity-relationship-studies(b5565787-3be0-4e48-8dac-9092ed30584e).html
https://biblio.vub.ac.be/vubir/optimized-opioidneurotensin-multitarget-peptides-from-design-to-structureactivity-relationship-studies(b5565787-3be0-4e48-8dac-9092ed30584e).html
Publikováno v:
Medicinal Chemistry. 14:400-408
Background Benzazepines received great attention in the field of medicinal chemistry since this scaffold has been recognized to belong to the important family of privileged templates. More specifically, the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa1935b071284123fbeb5fcf6dbe5c3
https://doi.org/10.2174/1573406413666171002122233
https://doi.org/10.2174/1573406413666171002122233
Autor:
Jean Martinez, Steven Ballet, Astrid Knuhtsen, Olivier Van der Poorten, Lubomir Vezenkov, Nadir Bettache, Baptiste Legrand, Macarena Sánchez-Navarro, Marcel Garcia, Dirk Tourwé, Muriel Amblard, Júlia García-Pindado, Meritxell Teixidó, Daniel Sejer Pedersen
Publikováno v:
ChemBioChem. 19:696-705
Non-cationic and amphipathic indoloazepinone-constrained (Aia) oligomers have been synthesized as new vectors for intracellular delivery. The conformational preferences of the [l-Aia-Xxx]n oligomers were investigated by circular dichroism (CD) and NM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd8dff07d861eef58bdf3d4545b139f
https://doi.org/10.1002/cbic.201700678
https://doi.org/10.1002/cbic.201700678
Autor:
Dirk Tourwé, Nikolaos A. Parisis, Steven Ballet, Andreas G. Tzakos, Mark P. Del Borgo, Olivier Van der Poorten, Antonis D. Tsiailanis, Baydaa Hirmiz, Robert E Widdop, Marie-Isabel Aguilar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 43:128086
The Renin-Angiotensin System (RAS) plays a crucial role in numerous pathological conditions. Two of the critical RAS players, the angiotensin receptors AT1R and AT2R, possess differential functional profiles, although they share high sequence similar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf6bd8b89afa140b4f0029ed1b566c5
https://doi.org/10.1016/j.bmcl.2021.128086
https://doi.org/10.1016/j.bmcl.2021.128086
Publikováno v:
European Journal of Organic Chemistry. 2017:4678-4694
This microreview briefly summarises recent developments in cyclisation to afford small, medium and large rings (five to 30 members) by way of both catalysed and uncatalysed azide–alkyne cycloaddition (AAC). The standard AAC reactions – intramolec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af02c0f4a1804615e48426ff107096b
https://doi.org/10.1002/ejoc.201700521
https://doi.org/10.1002/ejoc.201700521