Výsledky vyhledávání - "Dirk Smikalla"

Dexamethasone prevents LPS-induced microglial activation and astroglial impairment in an experimental bacterial meningitis co-culture model

Autor: Andreas Schoebel, Pedro M. Faustmann, Georg Zoidl, Dirk Smikalla, Daniel Hinkerohe, Uwe Schlegel, Claus G. Haase, Aiden Haghikia

Publikováno v: Brain Research. 1329:45-54

We analyzed the effect of dexamethasone on gram-negative bacteria derived lipopolysaccharide (LPS) induced inflammation in astroglial/microglial co-cultures. At the cellular level the microglial phenotype converted to an activated type after LPS incu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1123146cb4a045aaf5d87c6061f280
https://doi.org/10.1016/j.brainres.2010.03.012

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Intracellular application of TNF-alpha impairs cell to cell communication via gap junctions in glioma cells

Autor: Pauline Lafenêtre, Daniel Hinkerohe, Aiden Haghikia, Kerstin Ladage, Rolf Dermietzel, Pedro M. Faustmann, Arash Haghikia, Claus G. Haase, Dirk Smikalla

Publikováno v: Journal of Neuro-Oncology. 86:143-152

Human gliomas are the most common class of brain neoplasm. In order to better characterize their response to inflammation, we evaluated the influence of tumor necrosis factor alpha (TNF-alpha) on the coupling behaviour and the membrane resting potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40db3ed4720cf3c687b8052748919046
https://doi.org/10.1007/s11060-007-9462-8

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Effects of cytokines on microglial phenotypes and astroglial coupling in an inflammatory coculture model

Autor: Katharina Heupel, Dirk Smikalla, Aiden Haghikia, Claus G. Haase, Rolf Dermietzel, Daniel Hinkerohe, Pedro M. Faustmann

Publikováno v: Glia. 52:85-97

Cytokines play an important role in the onset, regulation, and propagation of immune and inflammatory responses within the central nervous system (CNS). The main source of cytokines in the CNS are microglial cells. Under inflammatory conditions, micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f834089f1b0433f21e49c90207c175c1
https://doi.org/10.1002/glia.20223

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Microglia activation influences dye coupling and Cx43 expression of the astrocytic network

Autor: Dominika Szlachta, Dorothee Krause, Sabine Romberg, Rolf Dermietzel, Pedro M. Faustmann, Daniel Hinkerohe, Dirk Smikalla, Claus G. Haase

Publikováno v: Glia. 42(2)

Under inflammatory conditions, activated microglia are capable of producing proinflammatory cytokines that are reported to influence cell-to-cell communication. The present study was performed to evaluate the influence of microglial activation on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eea3328b50670e67c6863eff1065c42
https://pubmed.ncbi.nlm.nih.gov/12655594

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