Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Dirk E. Martens"'
Autor:
Kylie Hesp, Jans M. E. van der Heijden, Stephanie Munroe, Detmer Sipkema, Dirk E. Martens, Rene H. Wijffels, Shirley A. Pomponi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The potential of sponge-derived chemicals for pharmaceutical applications remains largely unexploited due to limited available biomass. Although many have attempted to culture marine sponge cells in vitro to create a scalable production plat
Externí odkaz:
https://doaj.org/article/ade6368b29044d5f976d33f6f4798005
Autor:
Lucas Nik Reger, Martin Saballus, Annika Kappes, Markus Kampmann, Rene H. Wijffels, Dirk E. Martens, Julia Niemann
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Monoclonal antibodies (mAb) are commonly manufactured by either discontinuous operations like fed-batch (FB) or continuous processes such as steady-state perfusion. Both process types comprise opposing advantages and disadvantages in areas such as pl
Externí odkaz:
https://doaj.org/article/1b37f17414ba4accb90602fdac2bd5c2
Autor:
Lucas Nik Reger, Martin Saballus, Markus Kampmann, Rene H. Wijffels, Dirk E. Martens, Julia Niemann
Publikováno v:
Bioengineering, Vol 10, Iss 12, p 1391 (2023)
Monoclonal antibodies are the workhorse of the pharmaceutical industry due to their potential to treat a variety of different diseases while providing high specificity and efficiency. As a consequence, a variety of production processes have been esta
Externí odkaz:
https://doaj.org/article/21cce618a42648e7b384f4e7a01a7f43
Autor:
Lucas Nik Reger, Martin Saballus, Jens Matuszczyk, Markus Kampmann, Rene H. Wijffels, Dirk E. Martens, Julia Niemann
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Monoclonal antibodies (mAb) have gained enormous therapeutic application during the last decade as highly efficient and flexible tools for the treatment of various diseases. Despite this success, there remain opportunities to drive down the manufactu
Externí odkaz:
https://doaj.org/article/bfd18d78c01c4adc8b8a526f3d05f4a5
Autor:
Linda van Oosten, Jort J. Altenburg, Cyrielle Fougeroux, Corinne Geertsema, Fred van den End, Wendy A. C. Evers, Adrie H. Westphal, Simon Lindhoud, Willy van den Berg, Daan C. Swarts, Laurens Deurhof, Andreas Suhrbier, Thuy T. Le, Shessy Torres Morales, Sebenzile K. Myeni, Marjolein Kikkert, Adam F. Sander, Willem Adriaan de Jongh, Robert Dagil, Morten A. Nielsen, Ali Salanti, Max Søgaard, Timo M. P. Keijzer, Dolf Weijers, Michel H. M. Eppink, René H. Wijffels, Monique M. van Oers, Dirk E. Martens, Gorben P. Pijlman
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Vaccines pave the way out of the SARS-CoV-2 pandemic. We have developed a virus-like particle (VLP)-based vaccine using the baculovirus-insect cell expression system, a robust production platform known for its scalability, low cost, and safety. Bacul
Externí odkaz:
https://doaj.org/article/9d799f0e15554e7aafc11f877069c7c0
Autor:
Kylie Hesp, John L. Flores Alvarez, Ana-Maria Alexandru, Jip van der Linden, Dirk E. Martens, Rene H. Wijffels, Shirley A. Pomponi
Publikováno v:
Frontiers in Marine Science, Vol 7 (2020)
Sponges and their associated microorganisms are the most prolific source of marine natural products, and many attempts have been made at creating a marine sponge cell line to produce these products efficiently. However, limited knowledge on the nutri
Externí odkaz:
https://doaj.org/article/b862e54857624874a6e5165f70a9859a
Autor:
Matthias J. H. Gerritzen, Ronald H. W. Maas, Jan van den Ijssel, Lonneke van Keulen, Dirk E. Martens, René H. Wijffels, Michiel Stork
Publikováno v:
Microbial Cell Factories, Vol 17, Iss 1, Pp 1-10 (2018)
Abstract Background Outer membrane vesicles (OMVs) are nanoparticles released by Gram-negative bacteria and can be used as vaccines. Often, detergents are used to promote release of OMVs and to remove the toxic lipopolysaccharides. Lipopolysaccharide
Externí odkaz:
https://doaj.org/article/6cd9142f0f5a471fad568b9e5d595e9b
Autor:
Lenneke de Winter, Iago Teles Dominguez Cabanelas, Dirk E. Martens, René H. Wijffels, Maria J. Barbosa
Publikováno v:
Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract Background Day/night cycles regulate the circadian clock of organisms to program daily activities. Many species of microalgae have a synchronized cell division when grown under a day/night cycle, and synchronization might influence biomass y
Externí odkaz:
https://doaj.org/article/8d208a9046b242db8029ae4c60a34c9a
Autor:
Gorben P. Pijlman, Carissa Grose, Tessy A. H. Hick, Herman E. Breukink, Robin van den Braak, Sandra R. Abbo, Corinne Geertsema, Monique M. van Oers, Dirk E. Martens, Dominic Esposito
Publikováno v:
Viruses, Vol 12, Iss 12, p 1448 (2020)
Baculovirus expression vectors are successfully used for the commercial production of complex (glyco)proteins in eukaryotic cells. The genome engineering of single-copy baculovirus infectious clones (bacmids) in E. coli has been valuable in the study
Externí odkaz:
https://doaj.org/article/8500244a4580486199fd2a92c3836476
Autor:
Jort J. Altenburg, Maarten Klaverdijk, Damien Cabosart, Laurent Desmecht, Sonja S. Brunekreeft‐Terlouw, Joshua Both, Vivian I. P. Tegelbeckers, Marieke L. P. M. Willekens, Linda van Oosten, Tessy A. H. Hick, Tom M. H. van der Aalst, Gorben P. Pijlman, Monique M. van Oers, René H. Wijffels, Dirk E. Martens
Publikováno v:
Biotechnology Progress 39 (2023) 2
Biotechnology Progress, 39(2)
Biotechnology Progress, 39(2)
Real-time, detailed online information on cell cultures is essential for understanding modern biopharmaceutical production processes. The determination of key parameters, such as cell density and viability, is usually based on the offline sampling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34304b0b912c3e36584ba4e1d958d52c
https://doi.org/10.1002/btpr.3318
https://doi.org/10.1002/btpr.3318