Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Dirk, Wohlleber"'
Autor:
Knud Esser, Xiaoming Cheng, Jochen M. Wettengel, Julie Lucifora, Lea Hansen-Palmus, Katharina Austen, Armando A. Roca Suarez, Sarah Heintz, Barbara Testoni, Firat Nebioglu, Minh Tu Pham, Shangqing Yang, Alma Zernecke, Dirk Wohlleber, Marc Ringelhan, Mathias Broxtermann, Daniel Hartmann, Norbert Hüser, Julia Mergner, Andreas Pichlmair, Wolfgang E. Thasler, Mathias Heikenwalder, Georg Gasteiger, Andreas Blutke, Axel Walch, Percy A. Knolle, Ralf Bartenschlager, Ulrike Protzer
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 2, Pp 201-221 (2023)
Background & Aims: A single hepatitis B virus (HBV) particle is sufficient to establish chronic infection of the liver after intravenous injection, suggesting that the virus targets hepatocytes via a highly efficient transport pathway. We therefore i
Externí odkaz:
https://doaj.org/article/9fd675743fc64b5f93ebf586a31ab2ba
Autor:
Beatrice T. Laudenbach, Karsten Krey, Quirin Emslander, Line Lykke Andersen, Alexander Reim, Pietro Scaturro, Sarah Mundigl, Christopher Dächert, Katrin Manske, Markus Moser, Janos Ludwig, Dirk Wohlleber, Andrea Kröger, Marco Binder, Andreas Pichlmair
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
RNA of some viruses is protected from degradation by a 5′ triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.
Externí odkaz:
https://doaj.org/article/83808abd13804cb1901e95ef41afb37f
Autor:
Marcus Brugger, Melanie Laschinger, Sandra Lampl, Annika Schneider, Katrin Manske, Dena Esfandyari, Norbert Hüser, Daniel Hartmann, Katja Steiger, Stefan Engelhardt, Dirk Wohlleber, Percy A. Knolle
Publikováno v:
JHEP Reports, Vol 4, Iss 5, Pp 100465- (2022)
Background & Aims: Increased sensitivity towards tumor necrosis factor (TNF)-induced cell death in virus-infected hepatocytes has revealed a so far unrecognized hepatocyte-intrinsic antiviral immune surveillance mechanism, for which no in vitro or ex
Externí odkaz:
https://doaj.org/article/d30298ff222c47149b68e90c4a9b5176
Autor:
Annika Schneider, Sandra Kurz, Katrin Manske, Marianne Janas, Mathias Heikenwälder, Thomas Misgeld, Michaela Aichler, Sebastian Felix Weissmann, Hans Zischka, Percy Knolle, Dirk Wohlleber
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Mitochondria are key for cellular metabolism and signalling processes during viral infection. We report a methodology to analyse mitochondrial properties at the single-organelle level during viral infection using a recombinant adenovirus cod
Externí odkaz:
https://doaj.org/article/9deaae37133b4a689730d1568a261e15
Autor:
Yuhan Yin, Anna Sichler, Josef Ecker, Melanie Laschinger, Gerhard Liebisch, Marcus Höring, Marijana Basic, André Bleich, Xue-Jun Zhang, Ludwig Kübelsbeck, Johannes Plagge, Emely Scherer, Dirk Wohlleber, Jianye Wang, Yang Wang, Marcella Steffani, Pavel Stupakov, Yasmin Gärtner, Fabian Lohöfer, Carolin Mogler, Helmut Friess, Daniel Hartmann, Bernhard Holzmann, Norbert Hüser, Klaus-Peter Janssen
Publikováno v:
Journal of Hepatology. 78:820-835
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a25748f5bf50972b4dac2d6705f14b1
https://doi.org/10.1016/j.jhep.2022.12.028
https://doi.org/10.1016/j.jhep.2022.12.028
Autor:
Katrin Manske, Annika Schneider, Chunkyu Ko, Percy A. Knolle, Katja Steiger, Ulrike Protzer, Dirk Wohlleber
Publikováno v:
Viruses, Vol 13, Iss 11, p 2273 (2021)
Immunity against hepatitis B virus (HBV) infection is complex and not entirely understood so far, including the decisive factors leading to the development of chronic hepatitis B. This lack of a mechanistic understanding of HBV-specific immunity is a
Externí odkaz:
https://doaj.org/article/4f515b1db01a4d0f9470d29af1867d8b
Publikováno v:
Vaccines, Vol 9, Iss 11, p 1333 (2021)
Chronic hepatitis B affects more than 250 million individuals worldwide, putting them at risk of developing liver cirrhosis and liver cancer. While antiviral immune responses are key to eliminating hepatitis B virus (HBV) infections, insufficient ant
Externí odkaz:
https://doaj.org/article/312508e884104ee695c394701ea6736e
Autor:
Eva Schrom, Maja Huber, Manish Aneja, Christian Dohmen, Daniela Emrich, Johannes Geiger, Günther Hasenpusch, Annika Herrmann-Janson, Verena Kretzschmann, Olga Mykhailyk, Tamara Pasewald, Prajakta Oak, Anne Hilgendorff, Dirk Wohlleber, Heinz-Gerd Hoymann, Dirk Schaudien, Christian Plank, Carsten Rudolph, Rebekka Kubisch-Dohmen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 350-365 (2017)
Changes in lifestyle and environmental conditions give rise to an increasing prevalence of liver and lung fibrosis, and both have a poor prognosis. Promising results have been reported for recombinant angiotensin-converting enzyme 2 (ACE2) protein ad
Externí odkaz:
https://doaj.org/article/067d30ab42c94fd7a7632e3a5b0cfe2c
Publikováno v:
Annual Review of Analytical Chemistry. 15:1-16
Cellular organelles are highly specialized compartments with distinct functions. With the increasing resolution of detection methods, it is becoming clearer that same organelles may have different functions or properties not only within different cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f43cee6fea6e5d5a38700955f700ceb
https://doi.org/10.1146/annurev-anchem-061020-111722
https://doi.org/10.1146/annurev-anchem-061020-111722
Autor:
Sebastian J. Schober, Melanie Thiede, Hendrik Gassmann, Carolin Prexler, Busheng Xue, David Schirmer, Dirk Wohlleber, Stefanie Stein, Thomas G. P. Grünewald, Dirk H. Busch, Guenther H. S. Richter, Stefan E. G. Burdach, Uwe Thiel
Publikováno v:
Cells, Vol 9, Iss 7, p 1581 (2020)
In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4+ versus CD8+ T cells targeting a peptide from six transmembrane epithelial antigen of the prostate 1 (
Externí odkaz:
https://doaj.org/article/0469f1a4caae43debbaa3450bb0f0170