Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Dirk, Schaudien"'
Autor:
Antonella L. Bastone, Violetta Dziadek, Philipp John-Neek, Friederike Mansel, Jenni Fleischauer, Eric Agyeman-Duah, Dirk Schaudien, Oliver Dittrich-Breiholz, Adrian Schwarzer, Axel Schambach, Michael Rothe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 515-533 (2023)
Safety assessment in retroviral vector-mediated gene therapy remains challenging. In clinical trials for different blood and immune disorders, insertional mutagenesis led to myeloid and lymphoid leukemia. We previously developed the In Vitro Immortal
Externí odkaz:
https://doaj.org/article/4d961949250f4d17b1e74ea409031a0e
Autor:
Emilie Kirstein, Dirk Schaudien, Mathias Wagner, Coline M. Diebolt, Alessandro Bozzato, Thomas Tschernig, Colya N. Englisch
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4392 (2024)
Transient receptor potential canonical sub-family channel 3 (TRPC3) is considered to play a critical role in calcium homeostasis. However, there are no established findings in this respect with regard to TRPC6. Although the parathyroid gland is a cru
Externí odkaz:
https://doaj.org/article/585965eebd7e4da8badfb255e41de3bd
Autor:
Jenni Fleischauer, Antonella Lucia Bastone, Anton Selich, Philipp John-Neek, Luisa Weisskoeppel, Dirk Schaudien, Axel Schambach, Michael Rothe
Publikováno v:
Cells, Vol 12, Iss 15, p 1978 (2023)
Murine hematopoietic stem and progenitor cells (HSPCs) are commonly used as model systems during gene therapeutic retroviral vector development and preclinical biosafety assessment. Here, we developed cell culture conditions to maintain stemness and
Externí odkaz:
https://doaj.org/article/b5b2afbbff114c7087cce1d60b31eee8
Autor:
Julia K. Bialek-Waldmann, Sabine Domning, Ruth Esser, Wolfgang Glienke, Mira Mertens, Krasimira Aleksandrova, Lubomir Arseniev, Suresh Kumar, Andreas Schneider, Johannes Koenig, Sebastian J. Theobald, Hsin-Chieh Tsay, Angela D.A. Cornelius, Agnes Bonifacius, Britta Eiz-Vesper, Constanca Figueiredo, Dirk Schaudien, Steven R. Talbot, Andre Bleich, Loukia M. Spineli, Constantin von Kaisenberg, Caren Clark, Rainer Blasczyk, Michael Heuser, Arnold Ganser, Ulrike Köhl, Farzin Farzaneh, Renata Stripecke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 621-641 (2021)
Acute myeloid leukemia (AML) patients with minimal residual disease and receiving allogeneic hematopoietic stem cell transplantation (HCT) have poor survival. Adoptive administration of dendritic cells (DCs) presenting the Wilms tumor protein 1 (WT1)
Externí odkaz:
https://doaj.org/article/aa4cf9a177124c648d5410e058e734cf
Publikováno v:
Frontiers in Public Health, Vol 10 (2022)
Various synthetic powders with primary particle sizes at the nanoscale and a high commercial impact have been studied using Wistar rats. The test materials were metal oxides, i.e., TiO2, ZnO and amorphous silica, and carbon black (technical soot). Do
Externí odkaz:
https://doaj.org/article/c289c661e8304f63a5e0a3aff4e2d2de
Autor:
Maike Stahlhut, Teng Cheong Ha, Ekaterina Takmakova, Michael A. Morgan, Adrian Schwarzer, Dirk Schaudien, Matthias Eder, Axel Schambach, Olga S. Kustikova
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Regulation of haematopoietic stem cell fate through conditional gene expression could improve understanding of healthy haematopoietic and leukaemia initiating cell (LIC) biology. We established conditionally immortalised myeloid progenitor c
Externí odkaz:
https://doaj.org/article/abfa46b0214b432b946d8f86d4a0f23f
Autor:
Tom Schreiner, Lisa Allnoch, Georg Beythien, Katarzyna Marek, Kathrin Becker, Dirk Schaudien, Stephanie Stanelle-Bertram, Berfin Schaumburg, Nancy Mounogou Kouassi, Sebastian Beck, Martin Zickler, Gülsah Gabriel, Wolfgang Baumgärtner, Federico Armando, Malgorzata Ciurkiewicz
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5124 (2022)
Similar to many other respiratory viruses, SARS-CoV-2 targets the ciliated cells of the respiratory epithelium and compromises mucociliary clearance, thereby facilitating spread to the lungs and paving the way for secondary infections. A detailed und
Externí odkaz:
https://doaj.org/article/754a6c7b008643068c20876c14265e21
Autor:
Otto Creutzenberg, Helena Oliveira, Lucian Farcal, Dirk Schaudien, Ana Mendes, Ana Catarina Menezes, Tatjana Tischler, Sabina Burla, Christina Ziemann
Publikováno v:
Nanomaterials, Vol 12, Iss 8, p 1254 (2022)
Graphene-related two-dimensional nanomaterials possess very technically promising characteristics, but gaps exist regarding their potential adverse health effects. Based on their nano-thickness and lateral micron dimensions, nanoplates exhibit partic
Externí odkaz:
https://doaj.org/article/8a6e1039a41b422fb4013d60da4ca98f
Autor:
Kokilavani Sivaraman, Sabine Wrenger, Bin Liu, Dirk Schaudien, Christina Hesse, Gema Gomez-Mariano, Sara Perez-Luz, Katherina Sewald, David DeLuca, Maria J Wurm, Paco Pino, Tobias Welte, Beatriz Martinez-Delgado, Sabina Janciauskiene
Publikováno v:
Journal of Leukocyte Biology. 113:58-70
Rodent models of lipopolysaccharide (LPS)–induced pulmonary inflammation are used for anti-inflammatory drug testing. We aimed to characterize mice responses to aerosolized LPS alone or with intraperitoneal (i.p.) delivery of alpha1-antitrypsin (AA
Autor:
Daniela Schwotzer, Monika Niehof, Dirk Schaudien, Heiko Kock, Tanja Hansen, Clemens Dasenbrock, Otto Creutzenberg
Publikováno v:
Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-25 (2018)
Abstract Background Understanding the molecular mechanisms of nanomaterial interacting with cellular systems is important for appropriate risk assessment. The identification of early biomarkers for potential (sub-)chronic effects of nanoparticles pro
Externí odkaz:
https://doaj.org/article/4ef1fca095f340739dce330b2f07efc7