Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Dirk, Schübeler"'
Autor:
Inês A. M. Barbosa, Rajaraman Gopalakrishnan, Samuele Mercan, Thanos P. Mourikis, Typhaine Martin, Simon Wengert, Caibin Sheng, Fei Ji, Rui Lopes, Judith Knehr, Marc Altorfer, Alicia Lindeman, Carsten Russ, Ulrike Naumann, Javad Golji, Kathleen Sprouffske, Louise Barys, Luca Tordella, Dirk Schübeler, Tobias Schmelzle, Giorgio G. Galli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo p
Externí odkaz:
https://doaj.org/article/e2b59d291ce047f9846c8773ccba1759
Autor:
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Marianne Bachmann Salvy, Rui Lopes, Inês Amorim Monteiro Barbosa, Cecile Delmas, Alexandra Hinniger, Suzanne Chau, Markus Kaufmann, Simon Haenni, Karolin Berneiser, Maria Wahle, Ivana Moravec, Alexandra Vissières, Tania Poetsch, Erik Ahrné, Nathalie Carte, Johannes Voshol, Elisabeth Bechter, Jacques Hamon, Marco Meyerhofer, Dirk Erdmann, Matteo Fischer, Therese Stachyra, Felix Freuler, Sascha Gutmann, César Fernández, Tobias Schmelzle, Ulrike Naumann, Guglielmo Roma, Kate Lawrenson, Cristina Nieto-Oberhuber, Amanda Cobos-Correa, Stephane Ferretti, Dirk Schübeler, Giorgio Giacomo Galli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extrace
Externí odkaz:
https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c
Autor:
Paul Adrian Ginno, Dimos Gaidatzis, Angelika Feldmann, Leslie Hoerner, Dilek Imanci, Lukas Burger, Frederic Zilbermann, Antoine H. F. M. Peters, Frank Edenhofer, Sébastien A. Smallwood, Arnaud R. Krebs, Dirk Schübeler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Local activity of the DNA methylation machinery remains poorly understood. Here, the authors present a theoretical and experimental framework to infer methylation and demethylation rates at genome scale in mouse embryonic stem cells, finding that mai
Externí odkaz:
https://doaj.org/article/d71bbc029bb84f98b2659275c30cb32d
Autor:
Ramesh Yelagandula, Karin Stecher, Maria Novatchkova, Luca Michetti, Georg Michlits, Jingkui Wang, Pablo Hofbauer, Gintautas Vainorius, Carina Pribitzer, Luke Isbel, Sasha Mendjan, Dirk Schübeler, Ulrich Elling, Julius Brennecke, Oliver Bell
Publikováno v:
Nat Cell Biol
ZNF462 haploinsufficiency is linked to Weiss-Kruszka syndrome, a genetic disorder characterized by neurodevelopmental defects, including autism. Though conserved in vertebrates and essential for embryonic development, the molecular functions of ZNF46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451f492e1c2dd0cec55301c224f8cfee
https://doi.org/10.1038/s41556-022-01051-2
https://doi.org/10.1038/s41556-022-01051-2
Autor:
Sebastian Kaluscha, Silvia Domcke, Christiane Wirbelauer, Michael B. Stadler, Sevi Durdu, Lukas Burger, Dirk Schübeler
Publikováno v:
Nature Genetics. 54:1895-1906
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats in mammalian genomes. To what extent this entails direct inhibition of transcription factor (TF) binding versus indirect inhibition via recruitment of methyl-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2985aaf6b5aeebfcacdd0b9419894bd7
https://doi.org/10.1038/s41588-022-01241-6
https://doi.org/10.1038/s41588-022-01241-6
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcrip
Externí odkaz:
https://doaj.org/article/471b40b50d8c49149705427b2d4eb93f
Publikováno v:
PLoS Genetics, Vol 13, Iss 12, p e1007102 (2017)
Genomic location can inform on potential function and recruitment signals for chromatin-associated proteins. High mobility group (Hmg) proteins are of similar size as histones with Hmga1 and Hmga2 being particularly abundant in replicating normal tis
Externí odkaz:
https://doaj.org/article/330fb0cedc414b0f99aee51ed792af9e
Autor:
Ewa Surdziel, Ieuan Clay, Florian Nigsch, Anke Thiemeyer, Cyril Allard, Gregory Hoffman, John S Reece-Hoyes, Tanushree Phadke, Romain Gambert, Caroline Gubser Keller, Marie-Gabrielle Ludwig, Birgit Baumgarten, Mathias Frederiksen, Dirk Schübeler, Klaus Seuwen, Tewis Bouwmeester, Barna D Fodor
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183679 (2017)
Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which are dictated by environmental c
Externí odkaz:
https://doaj.org/article/ee373e8c093841f49ffecddc87bb7dda
Autor:
Luke Isbel, Murat Iskar, Sevi Durdu, Ralph S. Grand, Joscha Weiss, Eric Hietter-Pfeiffer, Zuzanna Kozicka, Alicia K. Michael, Lukas Burger, Nicolas H. Thomä, Dirk Schübeler
The genomic binding sites of the transcription factor (TF) and tumour suppressor p53 are unusually diverse in regards to their chromatin features, including histone modifications, opening the possibility that chromatin provides context-dependence for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faaae4657dd0d41d0867003bacabb2de
https://doi.org/10.1101/2022.08.23.504916
https://doi.org/10.1101/2022.08.23.504916
Publikováno v:
Nature reviews. Genetics. 23(12)
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA sequence motifs embedded in chromatin. Understanding how motifs are accessed in chromatin is crucial to comprehend differential transcriptional responses and the phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72c7aed5af38c3f0248471829b25b6d
https://pubmed.ncbi.nlm.nih.gov/35831531
https://pubmed.ncbi.nlm.nih.gov/35831531