Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Autor: Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S. Henzel, Sabine M. Hölter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L. Pearson, Ildiko Racz, Birgit Rathkolb, Devon P. Ryan, Susanne Schröder, Irina Treise, Raffi Bekeredjian, Dirk H. Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Dan Ehninger

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)

Dietary restriction can extend the life of various model organisms. Here, Xie et al. show that intermittent periods of fasting achieved through every-other-day feeding protect mice against neoplastic disease but do not broadly delay organismal aging

Externí odkaz: https://doaj.org/article/212be03b3e8048e28651330ac60c124f

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis

Autor: Axel Walch, Tomas Ganz, Katarzyna Okreglicka, Michaela Aichler, Dirk Janik, Christian Buske, Cornelia Kuklik-Roos, Katja Muedder, Sandro Altamura, Camilla Ladinig, Mar tin Hrabé de Angelis, Timm Schroeder, Marcus Conrad, Naidu M. Vegi, Georg W. Bornkamm, Birgit Rathkolb, Lothar Hültner, Philipp S. Hoppe, Martina U. Muckenthaler, Frauke Neff, Manuela Schneider, Josef Mysliwietz, Manfred Kopf, Ana Rita da Silva

Publikováno v: Haematologica 105, 937-950 (2020)
Haematologica
Haematologica, 105 (4)

Glutathione peroxidase 4 (GPX4) is unique as it is the only enzyme that can prevent detrimental lipid peroxidation in vivo by reducing lipid peroxides to the respective alcohols thereby stabilizing oxidation products of unsaturated fatty acids. Durin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa98d93d77678efe2c4207c1c737f79
https://doi.org/10.3324/haematol.2018.212977

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

Autor: Lore Becker, Eva Kling, Evelyn Schiller, Ramona Zeh, Anja Schrewe, Sabine M Hölter, Ilona Mossbrugger, Julia Calzada-Wack, Valentina Strecker, Ilka Wittig, Iulia Dumitru, Tina Wenz, Andreas Bender, Michaela Aichler, Dirk Janik, Frauke Neff, Axel Walch, Leticia Quintanilla-Fend, Thomas Floss, Raffi Bekeredjian, Valérie Gailus-Durner, Helmut Fuchs, Wolfgang Wurst, Thomas Meitinger, Holger Prokisch, Martin Hrabě de Angelis, Thomas Klopstock

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114918 (2014)

Recently, mutations in the mitochondrial translation optimization factor 1 gene (MTO1) were identified as causative in children with hypertrophic cardiomyopathy, lactic acidosis and respiratory chain defect. Here, we describe an MTO1-deficient mouse

Externí odkaz: https://doaj.org/article/5fb946e312a94325a7492aee89c6f092

Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE−/− Alzheimer's mouse model

Autor: Soile Tapio, Stefan J. Kempf, Anna Saran, Martin R. Larsen, Ignacia Braga-Tanaka, Zarko Barjaktarovic, Dirk Janik, Frauke Neff, Satoshi Tanaka

Publikováno v: Kempf, S J, Janik, D, Barjaktarovic, Z, Braga-Tanaka III, I, Tanaka, S, Neff, F, Saran, A, Larsen, M R & Tapio, S 2016, ' Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/-Alzheimer's mouse model ', OncoTarget, vol. 7, no. 44, pp. 71817-71832 . https://doi.org/10.18632/oncotarget.12376
Oncotarget

Accruing data indicate that radiation-induced consequences resemble pathologies of neurodegenerative diseases such as Alzheimer´s. The aim of this study was to elucidate the effect on hippocampus of chronic low-dose-rate radiation exposure (1 mGy/da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f5748a814a715a96bb944fa622627d
https://doi.org/10.18632/oncotarget.12376

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

Autor: Andras Franko, Annette Feuchtinger, Helmut Fuchs, Bernd Reif, Hans-Ulrich Häring, Dirk Janik, Birgit Rathkolb, Annett Böddrich, Andreas Peter, Michaela Aichler, Andrés Camargo, Martin Hrabě de Angelis, Erich E. Wanker, Diana C. Rodriguez Camargo, Divita Garg, Frauke Neff

Publikováno v: Scientific Reports
Sci. Rep. 8:1116 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

The formation of amyloid fibrils by human islet amyloid polypeptide protein (hIAPP) has been implicated in pancreas dysfunction and diabetes. However, efficient treatment options to reduce amyloid fibrils in vivo are still lacking. Therefore, we test

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f517b968dc34ff8cd71111b568fd06
http://edoc.mdc-berlin.de/17048/1/17048oa.pdf