Zobrazeno 1 - 10
of 562
pro vyhledávání: '"Dirk, Jäger"'
Autor:
Dirk Jäger, Aileen Berger, Alexandra Tuch, Claudia Luckner‐Minden, Rosa Eurich, Mario Hlevnjak, Andreas Schneeweiss, Peter Lichter, Sebastian Aulmann, Claus‐Peter Heussel, Carlo Fremd, Richard Harbottle, Inka Zörnig, Patrick Schmidt
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/d760168d1320416e85cdc19cb58e2a0d
Autor:
Nicolas Hohmann, Martin Ronald Sprick, Moritz Pohl, Azaz Ahmed, Jürgen Burhenne, Marietta Kirchner, Lucian Le Cornet, Markus Kratzmann, Jacek Hajda, Albrecht Stenzinger, Karen Steindorf, Stefan Delorme, Heinz‐Peter Schlemmer, Sabine Riethdorf, Ron vanSchaik, Klaus Pantel, Jens Siveke, Thomas Seufferlein, Dirk Jäger, Walter E. Haefeli, Andreas Trumpp, Christoph Springfeld
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2483-2493 (2023)
Abstract Expression of CYP3A5 protein is a basal and acquired resistance mechanism of pancreatic ductal adenocarcinoma cells conferring protection against the CYP3A and CYP2C8 substrate paclitaxel through metabolic degradation. Inhibition of CYP3A is
Externí odkaz:
https://doaj.org/article/c68c01273a54478990c71f106d610b42
Autor:
Muhammad Hasan Bashari, Fengjuan Fan, Sonia Vallet, Martin Sattler, Melissa Arn, Claudia Luckner-Minden, Henning Schulze-Bergkamen, Inka Zörnig, Frederik Marme, Andreas Schneeweiss, Michael H. Cardone, Joseph T. Opferman, Dirk Jäger, Klaus Podar
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/d689eaffe9c24d3592f0869a4443c025
Autor:
Marten Meyer, Christina Parpoulas, Titouan Barthélémy, Jonas P. Becker, Pornpimol Charoentong, Yanhong Lyu, Selina Börsig, Nadja Bulbuc, Claudia Tessmer, Lisa Weinacht, David Ibberson, Patrick Schmidt, Rüdiger Pipkorn, Stefan B. Eichmüller, Peter Steinberger, Katharina Lindner, Isabel Poschke, Michael Platten, Stefan Fröhling, Angelika B. Riemer, Jessica C. Hassel, Maria Paula Roberti, Dirk Jäger, Inka Zörnig, Frank Momburg
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Peptide-loaded MHC class I (pMHC-I) multimers have revolutionized our capabilities to monitor disease-associated T cell responses with high sensitivity and specificity. To improve the discovery of T cell receptors (TCR) targeting neoantigens of indiv
Externí odkaz:
https://doaj.org/article/2562f0907ae7489481331f6d349419cb
Autor:
Philipp Reimold, Georgi Tosev, Adam Kaczorowski, Jana Friedhoff, Constantin Schwab, Viktoria Schütz, Magdalena Görtz, Niklas Panzer, Martina Heller, Cem Aksoy, Ruth Himmelsbach, Thomas Walle, Stefanie Zschäbitz, Dirk Jäger, Anette Duensing, Albrecht Stenzinger, Markus Hohenfellner, Stefan Duensing
Publikováno v:
Diagnostics, Vol 14, Iss 7, p 741 (2024)
Background: Renal cell carcinoma (RCC) is among the most lethal urologic malignancies once metastatic. Current treatment approaches for metastatic RCC (mRCC) involve immune checkpoint inhibitors (ICIs) that target the PD-L1/PD-1 axis. High PD-L1 expr
Externí odkaz:
https://doaj.org/article/024657d17a2c4da0b88ebf9657dd40fd
Autor:
Alessia Floerchinger, Jessica E. Klein, Maximiliane S. C. Finkbeiner, Theresa E. Schäfer, Gwendolin Fuchs, Johannes Doerner, Hubert Zirngibl, Maximilian Ackermann, Hans M. Kvasnicka, Kerry A. Chester, Dirk Jäger, Claudia R. Ball, Guy Ungerechts, Christine E. Engeland
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-15 (2023)
Abstract Treatment with oncolytic measles vaccines (MV) elicits activation of immune cells, including natural killer (NK) cells. However, we found that MV-activated NK cells show only modest direct cytotoxic activity against tumor cells. To specifica
Externí odkaz:
https://doaj.org/article/631734c3778d40469ec6d6b74ebecfb0
Autor:
Rūta Veinalde, Gemma Pidelaserra-Martí, Coline Moulin, Lara M. Jeworowski, Linda Küther, Christian J. Buchholz, Dirk Jäger, Guy Ungerechts, Christine E. Engeland
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 43-58 (2022)
PD-1/PD-L1 checkpoint blockade has achieved unprecedented success in cancer immunotherapy. Nevertheless, many immune-excluded tumors are resistant to therapy. Combination with oncolytic virotherapy may overcome resistance by inducing acute inflammati
Externí odkaz:
https://doaj.org/article/b0640d5bf54b4f37a29eefe3f960eb3d
Autor:
Sophia Stahl-Toyota, Christoph Nikendei, Ede Nagy, Stefan Bönsel, Ivo Rollmann, Inga Unger, Julia Szendrödi, Norbert Frey, Patrick Michl, Carsten Müller-Tidow, Dirk Jäger, Hans-Christoph Friederich, Achim Hochlehnert
Publikováno v:
PLoS ONE, Vol 18, Iss 6 (2023)
Background Mental comorbidities of physically ill patients lead to higher morbidity, mortality, health-care utilization and costs. Objective The aim of the study was to investigate the impact of mental comorbidity and physical multimorbidity on the l
Externí odkaz:
https://doaj.org/article/0a54fcd2d741461aad02c62394ed6192
Autor:
Rūta Veinalde, Gemma Pidelaserra-Martí, Coline Moulin, Chin Leng Tan, Theresa E. Schäfer, Na Kang, Claudia R. Ball, Jonas Leichsenring, Albrecht Stenzinger, Lars Kaderali, Dirk Jäger, Guy Ungerechts, Christine E. Engeland
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionPancreatic ductal adenocarcinoma (PDAC) is largely refractory to cancer immunotherapy with PD-1 immune checkpoint blockade (ICB). Oncolytic virotherapy has been shown to synergize with ICB. In this work, we investigated the combination of
Externí odkaz:
https://doaj.org/article/ba74acb47dae49da8309a7f9f1784388
Autor:
Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Inka Zörnig, Dirk Jäger, Niels Halama
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Pancreatic ductal adenocarcinoma (PDA) is usually unresponsive to immunotherapeutic approaches. However, tertiary lymphoid structures (TLS) are associated with favorable patient outcomes in PDA. A better understanding of the B cell infiltrate and bio
Externí odkaz:
https://doaj.org/article/d020feab911c4d1fb6e309f2b562b91a