Zobrazeno 1 - 10
of 366
pro vyhledávání: '"Dirk, Haller"'
Autor:
Helena Heimes, Deborah Häcker, Hélène Omer, Daan R. van der Veen, Silke Kiessling, Dirk Haller
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103419- (2024)
Summary: Chemostat systems can be used to cultivate complex intestinal microbial communities ex vivo. Here, we present a protocol to transfer bacteria from human fecal material into chemostat systems as well as settings to simulate infant or adult co
Externí odkaz:
https://doaj.org/article/e0682ec67f5b4ffd968b311123b5662f
Autor:
Alessio Fasano, Benoit Chassaing, Dirk Haller, Eduard Flores Ventura, Maria Carmen-Collado, Nitida Pastor, Omry Koren, Roberto Berni Canani
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Here, we explored the vast potential of microbiome-based interventions in preventing and managing non-communicable diseases including obesity, diabetes, allergies, celiac disease, inflammatory bowel diseases, malnutrition, and cardiovascular diseases
Externí odkaz:
https://doaj.org/article/ee606a47d25a4cec947553d4fa37ec12
Autor:
Björn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel J. Windross, Laura Neises, Neha Mishra, Danielle Harris, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie T. Stengel, Go Ito, Christina Krötz, Olivia I. Coleman, Christian Jaeger, Dirk Haller, Søren R. Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon E. Adolph, Elisabeth Letellier, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109173- (2024)
Summary: Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the me
Externí odkaz:
https://doaj.org/article/b82b754dd2874bbc89024fd998a49788
Autor:
Amira Metwaly, Jelena Jovic, Nadine Waldschmitt, Sevana Khaloian, Helena Heimes, Deborah Häcker, Mohamed Ahmed, Nassim Hammoudi, Lionel Le Bourhis, Aida Mayorgas, Kolja Siebert, Marijana Basic, Tobias Schwerd, Matthieu Allez, Julian Panes, Azucena Salas, André Bleich, Sebastian Zeissig, Pamela Schnupf, Fabio Cominelli, Dirk Haller
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Background Crohn’s disease (CD) is associated with changes in the microbiota, and murine models of CD-like ileo-colonic inflammation depend on the presence of microbial triggers. Increased abundance of unknown Clostridiales and the microsc
Externí odkaz:
https://doaj.org/article/160bf4e0935a4c559e27d044a98b7180
Autor:
Marjolein Heddes, Baraa Altaha, Yunhui Niu, Sandra Reitmeier, Karin Kleigrewe, Dirk Haller, Silke Kiessling
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here, Heddes et al. demonstrate a major role for the intestinal circadian clock in driving microbiome dynamics. Microbiota transfer from intestinal clock-deficient mice promotes altered intestinal phenotypes, highlighting the importance of functional
Externí odkaz:
https://doaj.org/article/2e8c0f4ee7c04ba0adfbb9030ee7f77d
Autor:
Nikole Radani, Amira Metwaly, Sandra Reitmeier, Theresa Baumeister, Jonas Ingermann, Julia Horstmann, Akanksha Anand, Ingrid Gatz, Florian Kohlmayer, Klaus-Peter Janssen, Julia Slotta-Huspenina, Roland M. Schmid, Dirk Haller, Julian A. Abrams, Michael Quante
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 5, Pp 755-766 (2022)
Background and Aims: Esophageal adenocarcinoma (EAC) incidence has risen dramatically in the Western countries over the past decades. The underlying reasons are incompletely understood, and shifts in the esophageal microbiome have been postulated to
Externí odkaz:
https://doaj.org/article/ecf22d062de1458e84dc182c4f71316e
Autor:
Baraa Altaha, Marjolein Heddes, Violetta Pilorz, Yunhui Niu, Elizaveta Gorbunova, Michael Gigl, Karin Kleigrewe, Henrik Oster, Dirk Haller, Silke Kiessling
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101628- (2022)
Objective: Internal clocks time behavior and physiology, including the gut microbiome, in a circadian (∼24 h) manner. Mismatch between internal and external time, e.g. during shift work, disrupts circadian system coordination promoting the developm
Externí odkaz:
https://doaj.org/article/3a06fa1c0073488db168374a62acb59f
Autor:
David Schult, Sandra Reitmeier, Plamena Koyumdzhieva, Tobias Lahmer, Moritz Middelhoff, Johanna Erber, Jochen Schneider, Juliane Kager, Marina Frolova, Julia Horstmann, Lisa Fricke, Katja Steiger, Moritz Jesinghaus, Klaus-Peter Janssen, Ulrike Protzer, Klaus Neuhaus, Roland M. Schmid, Dirk Haller, Michael Quante
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
There is a growing debate about the involvement of the gut microbiome in COVID-19, although it is not conclusively understood whether the microbiome has an impact on COVID-19, or vice versa, especially as analysis of amplicon data in hospitalized pat
Externí odkaz:
https://doaj.org/article/0d64f28858eb4fdba2a6630ef6f2d6ee
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 4, Pp 1757-1770 (2021)
Summary Environmental and host‐associated microbial communities are complex ecosystems, of which many members are still unknown. Hence, it is challenging to study community dynamics and important to create model systems of reduced complexity that m
Externí odkaz:
https://doaj.org/article/563005513a9345c699e68f7b66cd1c2d
Autor:
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activatio
Externí odkaz:
https://doaj.org/article/3d0a007713ee43918ce086163783b2d9