Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Dirk, Erdmann"'
Autor:
Yannick Mesrouze, Gustavo Aguilar, Marco Meyerhofer, Fedir Bokhovchuk, Catherine Zimmermann, Patrizia Fontana, Alexandra Vissières, Hans Voshol, Dirk Erdmann, Markus Affolter, Patrick Chène
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract The TEAD transcription factors are the most downstream elements of the Hippo pathway. Their transcriptional activity is modulated by different regulator proteins and by the palmitoylation/myristoylation of a specific cysteine residue. In thi
Externí odkaz:
https://doaj.org/article/f02b86fa3df24797a39ed636e8605ba1
Autor:
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Marianne Bachmann Salvy, Rui Lopes, Inês Amorim Monteiro Barbosa, Cecile Delmas, Alexandra Hinniger, Suzanne Chau, Markus Kaufmann, Simon Haenni, Karolin Berneiser, Maria Wahle, Ivana Moravec, Alexandra Vissières, Tania Poetsch, Erik Ahrné, Nathalie Carte, Johannes Voshol, Elisabeth Bechter, Jacques Hamon, Marco Meyerhofer, Dirk Erdmann, Matteo Fischer, Therese Stachyra, Felix Freuler, Sascha Gutmann, César Fernández, Tobias Schmelzle, Ulrike Naumann, Guglielmo Roma, Kate Lawrenson, Cristina Nieto-Oberhuber, Amanda Cobos-Correa, Stephane Ferretti, Dirk Schübeler, Giorgio Giacomo Galli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extrace
Externí odkaz:
https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
PDF - 60K, Linear correlation observed between tumor growth inhibition (% T/C) or tumor regression and the fraction of time over the in vivo S473P-Akt IC80 in different cancer cell line-derived tumor xenografts implanted in nude mice (represented as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c451963b6c78f1e12fd0af2cb9344
https://doi.org/10.1158/1535-7163.22500847.v1
https://doi.org/10.1158/1535-7163.22500847.v1
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
Somatic PIK3CA mutations are frequently found in solid tumors, raising the hypothesis that selective inhibition of PI3Kα may have robust efficacy in PIK3CA-mutant cancers while sparing patients the side-effects associated with broader inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d1880b1b9abb1f6035e8d18e36185fc
https://doi.org/10.1158/1535-7163.c.6536590.v1
https://doi.org/10.1158/1535-7163.c.6536590.v1
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
PDF - 129K, Legends for Supplementary Figures 1 through 4 and Supplementary Tables 1 through 7. Supplementary Table 1. Determination of NVP-BYL719 in vitro effects on human protein kinases. Supplementary Table 2. Activity profile of NVP-BYL719 in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295e1f6fc6768a196f59f54ff9ba1231
https://doi.org/10.1158/1535-7163.22500844.v1
https://doi.org/10.1158/1535-7163.22500844.v1
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
PDF - 71K, Rat1-myr-p110alpha (blue), beta (green) or delta (red) cells were treated with increasing concentrations of NVP-BYL719 for 30 minutes. Levels of S473P-Akt in cell extracts were quantified by Reverse Phase Protein Array as described in (18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a02ee14f5f344ca6973b40eeaaaa26f
https://doi.org/10.1158/1535-7163.22500853
https://doi.org/10.1158/1535-7163.22500853
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
PDF - 92K, NVP-BYL719 does not inhibit mTOR and PIKKs involved in DNA damage-repair processes. A. TSC1 -/- MEFs cells were grown in a 96-well format and treated for 1 h with increased concentrations of RAD001 or NVP-BYL719 (from 0.5 nmol/L to 10 ?mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8197a6d90441300a276be28b78d902af
https://doi.org/10.1158/1535-7163.22500850
https://doi.org/10.1158/1535-7163.22500850
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
PDF - 37K, NVP-BYL719 was tested at 10 different concentrations (from 0.5 nmol/L to 10 μmol/L in 1 third dilution steps) against CLK2 (A) and LRRK2 (B). SelectScreenTM Kinase Profiling Service uses XLfit from IDBS to determine the IC50 values (IC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74b8da5e4235968139cffb97675bf08
https://doi.org/10.1158/1535-7163.22500856.v1
https://doi.org/10.1158/1535-7163.22500856.v1
Autor:
Carlos F. Barbas, Dirk Erdmann, Bruce E. Torbett, Dennis A. Sheeter, Arndt Brachat, Daniel Guthy, Sharon Bergquist, Mario P. Tschan, Pilar Blancafort
Supplementary Figure 2 from Modulation of drug resistance by artificial transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585a9653634796d7216e12181142e95c
https://doi.org/10.1158/1535-7163.22483788.v1
https://doi.org/10.1158/1535-7163.22483788.v1
Autor:
Carlos F. Barbas, Dirk Erdmann, Bruce E. Torbett, Dennis A. Sheeter, Arndt Brachat, Daniel Guthy, Sharon Bergquist, Mario P. Tschan, Pilar Blancafort
Supplementary Figure 1 from Modulation of drug resistance by artificial transcription factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a99e6dc796a3cd22fd64387083de52
https://doi.org/10.1158/1535-7163.22483791.v1
https://doi.org/10.1158/1535-7163.22483791.v1