Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Dirk, Daelemans"'
Autor:
Thomas Vercruysse, Els Vanstreels, Maarten Jacquemyn, Sandro Boland, Amuri Kilonda, Sara Allasia, Ilse Vandecaetsbeek, Hugo Klaassen, Matthias Versele, Patrick Chaltin, Arnaud Marchand, Dirk Daelemans
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nucle
Externí odkaz:
https://doaj.org/article/6d5b372d2108496cbb7b665ef0f808a6
Autor:
Vincent de Laat, Halit Topal, Xander Spotbeen, Ali Talebi, Jonas Dehairs, Jakub Idkowiak, Frank Vanderhoydonc, Tessa Ostyn, Peihua Zhao, Maarten Jacquemyn, Michele Wölk, Anna Sablina, Koen Augustyns, Tom Vanden Berghe, Tania Roskams, Dirk Daelemans, Maria Fedorova, Baki Topal, Johannes V. Swinnen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract A spontaneously occurring temperature increase in solid tumors has been reported sporadically, but is largely overlooked in terms of cancer biology. Here we show that temperature is increased in tumors of patients with pancreatic ductal aden
Externí odkaz:
https://doaj.org/article/8f15dc65565c4b5099ae63fd1bafc0fa
Autor:
Tatiane Assone, Soraya Maria Menezes, Fernanda de Toledo Gonçalves, Victor Angelo Folgosi, Marcos Braz, Jerusa Smid, Michel E. Haziot, Rosa M. N. Marcusso, Flávia E. Dahy, Augusto César Penalva de Oliveira, Evelien Vanderlinden, Sandra Claes, Dirk Daelemans, Jurgen Vercauteren, Dominique Schols, Jorge Casseb, Johan Van Weyenbergh
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Human T-Lymphotropic Virus type-1 (HTLV-1) is a unique retrovirus associated with both leukemogenesis and a specific neuroinflammatory condition known as HTLV-1-Associated Myelopathy (HAM). Currently, most proposed HAM biomarkers require invasive CSF
Externí odkaz:
https://doaj.org/article/0069aec1fea641599c5da5254ed3985f
Publikováno v:
Biosensors, Vol 14, Iss 8, p 362 (2024)
Orthoflaviviruses cause a major threat to global public health, and no antiviral treatment is available yet. Zika virus (ZIKV) entry, together with many other viruses, is known to be enhanced by phosphatidylserine (PS) receptors such as T-cell immuno
Externí odkaz:
https://doaj.org/article/db8590e2b8b44b2aa0598dee967d1205
Autor:
Jean Herman, Els Vanstreels, Dorothée Bardiot, Andrea E Prota, Natacha Gaillard, Ling-Jie Gao, Thomas Vercruysse, Leentje Persoons, Tinne Daems, Mark Waer, Piet Herdewijn, Thierry Louat, Michel O Steinmetz, Steven De Jonghe, Ben Sprangers, Dirk Daelemans
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0307153 (2024)
Microtubule-targeting agents are an important class of anti-cancer drugs; their full potential is however not realized because of significant myelotoxicity and neurotoxicity. We here report 3-nitropyridine analogues as a novel group of microtubule-ta
Externí odkaz:
https://doaj.org/article/6fdecf164cea42cdbd9b349cb2345daf
Autor:
Sabine Tejpar, Abhishek D Garg, Louis Boon, Massimiliano Mazzone, Jenny Sprooten, Isaure Vanmeerbeek, Stefan Naulaerts, Raquel Salvador, Jannes Govaerts, Rosa Trotta, Samantha Pretto, Shikang Zhao, Sarah Trusso Cafarello, Joren Verelst, Maarten Jacquemyn, Martyna Pociupany, Susan M Schlenner, Dirk Daelemans
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4d74b171dccc4687ac58e89d21d9fc32
Autor:
Tatiane Assone, Soraya Maria Menezes, Fernanda de Toledo Gonçalves, Victor Angelo Folgosi, Gabriela da Silva Prates, Tim Dierckx, Marcos Braz, Jerusa Smid, Michel E. Haziot, Rosa M. N. Marcusso, Flávia E. Dahy, Evelien Vanderlinden, Sandra Claes, Dominique Schols, Roberta Bruhn, Edward L. Murphy, Augusto César Penalva de Oliveira, Dirk Daelemans, Jurgen Vercauteren, Jorge Casseb, Johan Van Weyenbergh
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is an incapacitating neuroinflammatory disorder for which no disease-modifying therapy is available, but corticosteroids provide some clinical benefit. Although H
Externí odkaz:
https://doaj.org/article/a1b1dbdb7e4045c0b20219ba3b828e15
Autor:
Keren Lasker, Steven Boeynaems, Vinson Lam, Daniel Scholl, Emma Stainton, Adam Briner, Maarten Jacquemyn, Dirk Daelemans, Ashok Deniz, Elizabeth Villa, Alex S. Holehouse, Aaron D. Gitler, Lucy Shapiro
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
“Intracellular phase separation is emerging as a universal principle for organizing biochemical reactions in time and space. Here the authors show that PopZ condensate dynamics support cell division and using PopZ modular architecture, the tunable
Externí odkaz:
https://doaj.org/article/dea291a67d0a47ba85a97b024b6dede1
Publikováno v:
Molecules, Vol 28, Iss 20, p 7208 (2023)
A series of novel 2,6-diphenyl substituted imidazo[4,5-b]pyridines was designed and synthesized using optimized Suzuki cross coupling to evaluate their biological activity in vitro. The conditions of the Suzuki coupling were evaluated and optimized u
Externí odkaz:
https://doaj.org/article/6ad05f9049354cdebfc26b410827e2aa
Autor:
Anja Beč, Maja Cindrić, Leentje Persoons, Mihailo Banjanac, Vedrana Radovanović, Dirk Daelemans, Marijana Hranjec
Publikováno v:
Molecules, Vol 28, Iss 9, p 3720 (2023)
Herein, we present the design and synthesis of novel N-substituted benzimidazole-derived Schiff bases, and the evaluation of their antiviral, antibacterial, and antiproliferative activity. The impact on the biological activity of substituents placed
Externí odkaz:
https://doaj.org/article/d237f3365527426e993c24318d9204af