Zobrazeno 1 - 10
of 16 644
pro vyhledávání: '"Directed Evolution"'
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Improving crop traits requires genetic diversity, which allows breeders to select advantageous alleles of key genes. In species or loci that lack sufficient genetic diversity, synthetic directed evolution (SDE) can supplement natural variation, thus
Externí odkaz:
https://doaj.org/article/5f2a600c2b944db286321e1bfdfb5756
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 7691-7708 (2024)
Xun Zhou,1,2,* Jingzhou Liu,2,* Shuang Xiao,2,3,* Xiaoqing Liang,1,2 Yi Li,2 Fengzhen Mo,3 Xin Xin,2 Yang Yang,2 Chunsheng Gao1,2 1School of Pharmacy, Henan University, Kaifeng, People’s Republic of China; 2State Key Laboratory of Toxic
Externí odkaz:
https://doaj.org/article/58c2fe22206644798bb3b5c759c63da4
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract Adeno-associated viruses 2 (AAV2) are minute viruses renowned for their capacity to infect human cells and akin organisms. They have recently emerged as prominent candidates in the field of gene therapy, primarily attributed to their inheren
Externí odkaz:
https://doaj.org/article/553499d5eb064011adeae295355f32b3
Publikováno v:
Frontiers in Catalysis, Vol 4 (2024)
In the past 20 years, unspecific peroxygenases (UPOs) have emerged as promising biocatalysts for various organic transformations. Particularly, we have witnessed great attention being paid to the screening of new enzymes and expansion of the substrat
Externí odkaz:
https://doaj.org/article/5dc8d277b2a14b6fa0b7e7465b718a21
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Directed evolution is a powerful tool that can bypass gaps in our understanding of the sequence-function relationship of proteins and still isolate variants with desired activities, properties, and substrate specificities. The rise of directed evolut
Externí odkaz:
https://doaj.org/article/c1bc1e805d0a446b9d89e7f53b9ac9c8
Autor:
Yao‐An Yu, Wan‐Ju Lien, Wen‐Ching Lin, Yi‐Chung Pan, Sin‐Wei Huang, Chung‐Yuan Mou, Che‐Ming Jack Hu, Kurt Yun Mou
Publikováno v:
Advanced Science, Vol 11, Iss 33, Pp n/a-n/a (2024)
Abstract The development of immune cell engagers (ICEs) can be limited by logistical and functional restrictions associated with fusion protein designs, thus limiting immune cell recruitment to solid tumors. Herein, a high affinity superantigen‐bas
Externí odkaz:
https://doaj.org/article/268a26cde0e142bcba3823b5f3520a6e
Autor:
Shazrul Fazry, Ahmed Abdulkareem Najm, Ibrahim Mahmood Mahdi, Arnold Ang, LiTing Lee, Choy-Theng Loh, Sharifah Sakinah Syed Alwi, Fang Li, Douglas Law
Publikováno v:
PeerJ, Vol 12, p e17894 (2024)
Various studies have demonstrated that directed evolution is a powerful tool in enhancing protein properties. In this study, directed evolution was used to enhance the efficacy of synthesised Anabas testudineus AtMP1 antimicrobial peptides (AMPs) in
Externí odkaz:
https://doaj.org/article/e6a129619fad4f41a6c9370faeaeb3d9
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
D-Phenyllactic acid (D-PLA) is a potent antimicrobial typically synthesized through chemical methods. However, due to the complexity and large pollution of these reactions, a simpler and more eco-friendly approach was needed. In this study, a strain
Externí odkaz:
https://doaj.org/article/0d8325048ab541a8bf1a4e53101d48e1
Autor:
Shuiqin Jiang, Dong Yi
Publikováno v:
Pharmaceutical Fronts, Vol 06, Iss 03, Pp e252-e264 (2024)
Biocatalysis has been widely used to prepare drug leads and intermediates. Enzymatic synthesis has advantages, mainly in terms of strict chirality and regional selectivity compared with chemical methods. However, the enzymatic properties of wild-type
Externí odkaz:
https://doaj.org/article/50e9c66a55394bb2bf5ab684992e138d