Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot.

Autor: Barrios EL; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Mazer MB; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., McGonagill PW; Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Bergmann CB; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; University Hospital Ulm, Clinic for Trauma Surgery, Hand, Plastic, and Reconstructive Surgery Albert-Einstein-Allee 23, Ulm, Germany., Goodman MD; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Gould RW; Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Rao M; Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Polcz VE; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Davis RJ; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Del Toro DE; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Dirain ML; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Dram A; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Hale LO; Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Heidarian M; Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Kim CY; Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Kucaba TA; Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Lanz JP; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., McCray AE; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Meszaros S; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Miles S; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Nelson CR; Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Rocha IL; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Silva EE; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Ungaro RF; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Walton AH; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Xu J; Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Zeumer-Spataro L; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Drewry AM; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Liang M; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.; Department of Biostatistics, University of Florida College of Public Health and Health Professions and the University of Florida College of Medicine, Gainesville, Florida, USA., Bible LE; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Loftus TJ; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Turnbull IR; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Efron PA; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Remy KE; Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Brakenridge SC; Department of Surgery, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington, USA., Badovinac VP; Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.; Experimental Pathology PhD Program, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Griffith TS; Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.; Minneapolis VA Healthcare System, Minneapolis, Minnesota, USA., Moldawer LL; Sepsis and Critical Illness Research Center, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA., Hotchkiss RS; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA., Caldwell CC; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Jan 23; Vol. 9 (2). Date of Electronic Publication: 2024 Jan 23.

A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis.

Autor: Darden DB; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Dong X; Department of Biomedical Engineering, University of Florida College of Medicine, Gainesville, FL, United States., Brusko MA; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, United States., Kelly L; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Fenner B; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Rincon JC; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Dirain ML; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Ungaro R; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Nacionales DC; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Gauthier M; Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, United States., Kladde M; Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, United States., Brusko TM; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, United States., Bihorac A; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, United States., Moore FA; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Loftus T; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Bacher R; Department of Biostatistics, University of Florida, Gainesville, FL, United States., Moldawer LL; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Mohr AM; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States., Efron PA; Department of Surgery, University of Florida College of Medicine, Gainesville, FL, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Aug 16; Vol. 12, pp. 696536. Date of Electronic Publication: 2021 Aug 16 (Print Publication: 2021).

Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.

Autor: Mankowski RT; Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville, Florida., Thomas RM; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida.; Section of General Surgery, North Florida/South Georgia Veterans Health System, Gainesville, Florida., Darden DB; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Gharaibeh RZ; Department of Medicine, University of Florida, Gainesville, Florida., Hawkins RB; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Cox MC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Apple C; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Nacionales DC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Ungaro RF; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Dirain ML; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Moore FA; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Leeuwenburgh C; Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville, Florida., Brakenridge SC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Clanton TL; Department of Applied Physiology and Kinesiology, University of Florida College of Health and Human Performance, Gainesville, Florida., Laitano O; Department of Applied Physiology and Kinesiology, University of Florida College of Health and Human Performance, Gainesville, Florida., Moldawer LL; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Mohr AM; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida., Efron PA; Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville, Florida.; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, Florida.

Publikováno v: Shock (Augusta, Ga.) [Shock] 2021 Apr 01; Vol. 55 (4), pp. 519-525.

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.

Autor: Hollen MK; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Stortz JA; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Darden D; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Dirain ML; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Nacionales DC; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Hawkins RB; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Cox MC; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Lopez MC; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA., Rincon JC; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Ungaro R; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Wang Z; Department of Biostatistics, University of Florida College of Medicine, Gainesville, FL, USA., Wu Q; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Brumback B; Department of Biostatistics, University of Florida College of Medicine, Gainesville, FL, USA., Gauthier ML; Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA., Kladde M; Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA., Leeuwenburgh C; Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville, FL, USA., Segal M; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA., Bihorac A; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA., Brakenridge S; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Moore FA; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Baker HV; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA., Mohr AM; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Moldawer LL; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA., Efron PA; Department of Surgery, Shands Hospital, University of Florida College of Medicine, Room 6116, 1600 SW Archer Road, Gainesville, FL, 32610-0019, USA. philip.efron@surgery.ufl.edu.

Publikováno v: Critical care (London, England) [Crit Care] 2019 Nov 13; Vol. 23 (1), pp. 355. Date of Electronic Publication: 2019 Nov 13.

Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.

Autor: Raymond SL; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Hawkins RB; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Stortz JA; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Murphy TJ; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Ungaro R; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Dirain ML; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Nacionales DC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Hollen MK; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Rincon JC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Larson SD; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Brakenridge SC; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Moore FA; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Irimia D; Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America., Efron PA; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America., Moldawer LL; Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of America.

Publikováno v: PloS one [PLoS One] 2018 Oct 09; Vol. 13 (10), pp. e0205327. Date of Electronic Publication: 2018 Oct 09 (Print Publication: 2018).