Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Dipti V. Tillu"'
Autor:
Kenji Hanamura, Halley R. Washburn, Sean I. Sheffler-Collins, Nan L. Xia, Nathan Henderson, Dipti V. Tillu, Shayne Hassler, Daniel S. Spellman, Guoan Zhang, Thomas A. Neubert, Theodore J. Price, Matthew B. Dalva
Publikováno v:
PLoS Biology, Vol 19, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/ee726bf4dd72409bb93a6b137975995f
Autor:
Jamie K. Moy, Thomas Szabo-Pardi, Dipti V. Tillu, Salim Megat, Grishma Pradhan, Moeno Kume, Marina N. Asiedu, Michael D. Burton, Gregory Dussor, Theodore J. Price
Publikováno v:
Neurobiology of Pain, Vol 5, Iss , Pp - (2019)
Brain-derived neurotrophic factor (BDNF) signaling through its cognate receptor, TrkB, is a well-known promoter of synaptic plasticity at nociceptive synapses in the dorsal horn of the spinal cord. Existing evidence suggests that BDNF/TrkB signaling
Externí odkaz:
https://doaj.org/article/ac4227b8cd9546568e79bfd65ba62b36
Autor:
Scott Boitano, Justin Hoffman, Dipti V Tillu, Marina N Asiedu, Zhenyu Zhang, Cara L Sherwood, Yan Wang, Xinzhong Dong, Theodore J Price, Josef Vagner
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99140 (2014)
Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR2 with in vitro
Externí odkaz:
https://doaj.org/article/f422d5c90552473183a8efb73cc62b74
Autor:
Cara L. Sherwood, Marina N. Asiedu, Zhenyu Zhang, Josef Vagner, Dipti V. Tillu, Theodore J. Price, Scott Boitano, Candy M. Rivas, Justin Hoffman, Andrea N. Flynn, Kathryn DeFea
Publikováno v:
British Journal of Pharmacology. 172:4535-4545
Background and Purpose Proteinase-activated receptor-2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the four PARs that are activated by proteolytic cleavage of the extracellular amino terminus, resu
Autor:
Dipti V. Tillu, Travis Hughes, Theodore J. Price, Galo L. Mejia, Marina N. Asiedu, Bo Lian, Khadijah Mazhar, Kufreobong E. Inyang, Michael D. Burton, Gregory Dussor
Publikováno v:
Neuroscience. 359
New therapeutics to manage post-surgical pain are needed to mitigate the liabilities of opioid and other analgesics. Our previous work shows that key modulators of excitability in peripheral nociceptors, such as extracellular signal-regulated kinases
Autor:
Theodore J. Price, Halley R. Washburn, Guoan Zhang, Sean I. Sheffler-Collins, Nan L. Xia, Thomas A. Neubert, Dipti V. Tillu, Kenji Hanamura, Matthew B. Dalva, Nathan T Henderson, Daniel S. Spellman, Shayne N. Hassler
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 7, p e2002457 (2017)
PLoS Biology, Vol 15, Iss 7, p e2002457 (2017)
Extracellular phosphorylation of proteins was suggested in the late 1800s when it was demonstrated that casein contains phosphate. More recently, extracellular kinases that phosphorylate extracellular serine, threonine, and tyrosine residues of numer
Autor:
Andrea N. Flynn, Dipti V. Tillu, Marina N. Asiedu, Theodore J. Price, Renata Patek, Justin Hoffman, Zhenyu Zhang, Scott Boitano, Josef Vagner, Cara L. Sherwood
Publikováno v:
The FASEB Journal. 27:1498-1510
Protease-activated receptor-2 (PAR2) is a G-protein coupled receptor (GPCR) associated with a variety of pathologies. However, the therapeutic potential of PAR2 is limited by a lack of potent and specific ligands. Following proteolytic cleavage, PAR2
Autor:
Adia Shy, Frank Porreca, Theodore J. Price, Marina N. Asiedu, Ohannes K. Melemedjian, Dipti V. Tillu, Raul Sanoja, Bryce Bodell, Sourav Ghosh
Publikováno v:
The Journal of Neuroscience. 31:6646-6653
Sensitization of the pain pathway is believed to promote clinical pain disorders. We hypothesized that the persistence of a sensitized state in the spinal dorsal horn might depend on the activity of protein kinase M ζ (PKMζ), an essential mechanism
Publikováno v:
Pain. 136:331-339
The rostral ventromedial medulla (RVM) is involved in facilitation of spinal nociceptive processing and generation of hyperalgesia in inflammatory and neuropathic pain models. We hypothesized that the bilateral hyperalgesia that develops after repeat
Autor:
Stacie K. Totsch, Robert E. Sorge, Theodore J. Price, Tammie Quinn, Dipti V. Tillu, Elaine Murad, Adia Shy, Ji Young Kim, Galo L. Mejia, Gregory Dussor, Marina N. Asiedu, Alan P. Schumann, Patrick W. Mantyh
The mechanisms that lead to the maintenance of chronic pain states are poorly understood, but their elucidation could lead to new insights into how pain becomes chronic and how it can potentially be reversed. We investigated the role of spinal dorsal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b85c27a9b95c7ab3f34ef923b57b3c6
https://europepmc.org/articles/PMC4405552/
https://europepmc.org/articles/PMC4405552/