Zobrazeno 1 - 4
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pro vyhledávání: '"Dipti Kanabar"'
Autor:
Dipti Kanabar, Mimansa Goyal, Emma I. Kane, Tejashri Chavan, Abbas Kabir, Xuechun Wang, Snehal Shukla, Joseph Almasri, Sona Goswami, Gizem Osman, Marino Kokolis, Donald E. Spratt, Vivek Gupta, Aaron Muth
Publikováno v:
Journal of medicinal chemistry. 65(13)
Gankyrin is an oncoprotein responsible for the development of numerous cancer types. It regulates the expression levels of multiple tumor suppressor proteins (TSPs) in liver cancer; however, gankyrin's regulation of these TSPs in breast and lung canc
Autor:
Amber M. D’Souza, Manu Gnanamony, Maria Thomas, Peter Hanley, Dipti Kanabar, Pedro de Alarcon, Aaron Muth, Nikolai Timchenko
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3068
Background: Gankyrin, a member of the 26S proteasome, is an overexpressed oncoprotein in hepatoblastoma (HBL) and hepatocellular carcinoma (HCC). Cjoc42 was the first small molecule inhibitor of Gankyrin developed; however, the IC50 values of >50 μM