Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Diptesh Sil"'
Autor:
Diptesh Sil, Sudipta Panja, Chinmay M. Jogdeo, Raj Kumar, Ao Yu, Cassandra E. Holbert, Ling Ding, Jackson R. Foley, Tracy Murray Stewart, Robert A. Casero, David Oupický
Publikováno v:
Molecules, Vol 27, Iss 8, p 2441 (2022)
Conformationally restrained polyamine analog PG11047 is a well-known drug candidate that modulates polyamine metabolism and inhibits cancer cell growth in a broad spectrum of cancers. Here, we report a structure–activity relationship study of the P
Externí odkaz:
https://doaj.org/article/d5eb1279941147268625daa3f0da0089
Autor:
Chuhan Zhang, Yu Hang, Weimin Tang, Diptesh Sil, Heather C. Jensen-Smith, Robert G. Bennett, Benita L. McVicker, David Oupický
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 669 (2022)
Alcohol-associated liver disease (AALD) is a major cause of liver disorders worldwide. Current treatment options are limited, especially for AALD-associated fibrosis. Promising approaches include RNA interference for miR-155 overexpression in Kupffer
Externí odkaz:
https://doaj.org/article/372bcf1685d943d29308743cd40e5f69
Autor:
Neha Kumari, Kasturi Siddhanta, Sudipta Panja, Vineet Joshi, Chinmay Jogdeo, Ekta Kapoor, Rubayat Khan, Sai Sundeep Kollala, Balawant Kumar, Diptesh Sil, Amar B. Singh, Daryl J. Murry, David Oupický
Publikováno v:
Pharmaceutical Research. 40:107-122
Nucleic acid (NA) therapy has gained importance over the past decade due to its high degree of selectivity and minimal toxic effects over conventional drugs. Currently, intravenous (IV) or intramuscular (IM) formulations constitute majority of the ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc18da48514b98d9d188af872140a90c
https://doi.org/10.1007/s11095-022-03415-7
https://doi.org/10.1007/s11095-022-03415-7
Publikováno v:
ACS Symposium Series ISBN: 9780841297821
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18598abc91b5eeba50351d1b174e804c
https://doi.org/10.1021/bk-2022-1410.ch007
https://doi.org/10.1021/bk-2022-1410.ch007
Autor:
Ao Yu, Siyuan Tang, Ling Ding, Jackson Foley, Weimin Tang, Huizhen Jia, Sudipta Panja, Cassandra E. Holbert, Yu Hang, Tracy Murray Stewart, Lynette M. Smith, Diptesh Sil, Robert A. Casero, David Oupický
Publikováno v:
Biomater Adv
RNA interference (RNAi) is an emerging therapeutic modality for cancer, which remains in critical need of effective delivery vectors due to the unfavorable biopharmaceutical properties of small RNAs. Polyamines are essential for functioning of mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb657bc03b74ce9e71065d7688583b8
https://pubmed.ncbi.nlm.nih.gov/35929290
https://pubmed.ncbi.nlm.nih.gov/35929290
Autor:
Ling Ding, Siyuan Tang, Weimin Tang, Deanna D. Mosley, Ao Yu, Diptesh Sil, Svetlana Romanova, Kristina L. Bailey, Daren L. Knoell, Todd A. Wyatt, David Oupický
Publikováno v:
Advanced science (Weinheim, Baden-Wurttemberg, Germany). 9(8)
Local pulmonary administration of therapeutic siRNA represents a promising approach to the treatment of lung fibrosis, which is currently hampered by inefficient delivery. Development of perfluorooctylbromide (PFOB) nanoemulsions as a way of improvin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28b8c41bae0e378f9b19d0e6fe3372a
https://pubmed.ncbi.nlm.nih.gov/34994102
https://pubmed.ncbi.nlm.nih.gov/34994102
Autor:
Siyuan Tang, Ao Yu, Ying Xie, Chuhan Zhang, Yu Hang, David Oupický, Ling Ding, Weimin Tang, Diptesh Sil
Publikováno v:
Mol Pharm
Pancreatic ductal adenocarcinoma is a deadly disease with limited treatment options due to late diagnosis and resistance to conventional chemotherapy. Among emerging therapeutic targets, the CXCR4 chemokine receptor and polo-like kinase 1 (PLK1) play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124e032fbd9010bc380c3431ac1fc660
https://pubmed.ncbi.nlm.nih.gov/34699242
https://pubmed.ncbi.nlm.nih.gov/34699242
Autor:
David Oupický, Ying Xie, Fei Yu, Weimin Tang, Siyuan Tang, Diptesh Sil, Jing Li, Rakesh K. Singh, David Větvička, Ao Yu, Chuhan Zhang, Yu Hang
Publikováno v:
J Control Release
Pancreatic ductal adenocarcinoma (PDAC) is a growing medical problem associated with extensive metastasis and high mortality. Intraperitoneal (IP) administration of therapeutics promises to help the treatment of cancers originated from organs in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cd867e1d0b51d64fb50b0b51b9ad68
https://europepmc.org/articles/PMC8122076/
https://europepmc.org/articles/PMC8122076/
Autor:
Omar Faruk, Dulal Hosen, Abbas Ahmed, Mohammed Muzibur Rahman, Rahul Sharma, Asha Kumari, Anita Rani, Anita Kumari, Manita Thakur, Kanika Mandhan, Manisha Chandel, Ajay Sharma, Shuai Jiang, Amjad Farooq, Meiling Zhang, Mengmeng Li, Lifang Liu, Emad S. Goda, Austine Ofondu Chinomso Iroegbu, Suprakas Sinha Ray, Raj Kumar, Chandrani Sarkar, Sudipta Panja, Chandra Khatua, Kishan Gugulothu, Diptesh Sil, Farooq Sher, Muntaha Ilyas, Maimoona Ilyas, Umer Liaqat, Eder C. Lima, Mika Sillanpää, Jiří Jaromír Klemeš, Narayanamoorthy Bhuvanendran, Sabarinathan Ravichandran, Mathiyazhagan Narayanan, Balaji Paulraj, Suresh Kumarasamy, Huaneng Su, Sabariswaran Kandasamy, Gaurav Yadav, Md. Ahmaruzzaman, Dimpee Sarmah, Ashok Bora, Niranjan Karak, Sajjad Hussain, Puneet Kaur, Rohit, Deepika Jamwal, Jae Young Park, Akash Katoch, Smrutimedha Parida, Dimple P. Dutta, Rahul Kandpal, Mohammad Shahadat, Rohana Adnan, Syed Wazed Ali, Shaikh Ziauddin Ahammad
'Nanocomposites derived from biorenewable sources have emerged as an important material for applications as diverse as energy storage, medicine, and environmental remediation. These nanocomposites have a high surface-to-volume ratio, facilitating eas
Autor:
Mallesh Beesu, Diptesh Sil, Sunil A. David, Umeharu Ohto, Mihiri S. Weerasinghe, Karishma K. Khetani, Giuseppe Caruso, Toshiyuki Shimizu, H. Tanji, Alex C. D. Salyer
Publikováno v:
Journal of Medicinal Chemistry
Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and monocyte-derived dendritic cells. Engagement by TLR8 agonists evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8942e63844cd0bb219eaaf9cb9dfd67
https://doi.org/10.1021/acs.jmedchem.5b01087
https://doi.org/10.1021/acs.jmedchem.5b01087