Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants

Autor: Guanghao Qi, Surya B. Chhetri, Debashree Ray, Diptavo Dutta, Alexis Battle, Samsiddhi Bhattacharjee, Nilanjan Chatterjee

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Genome-wide association studies (GWAS) have found widespread evidence of pleiotropy, but characterization of global patterns of pleiotropy remain highly incomplete due to insufficient power of current approaches. We develop fastASSET, a meth

Externí odkaz: https://doaj.org/article/1574b5117381400db27d1c4f2f4c96c0

Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood

Autor: Diptavo Dutta, Yuan He, Ashis Saha, Marios Arvanitis, Alexis Battle, Nilanjan Chatterjee

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Large-scale genetic association studies have identified many trait-associated variants that influence gene expression. Here, the authors present ARCHIE, a tool for identifying sets of genes whose regulation may be related to specific complex traits.

Externí odkaz: https://doaj.org/article/14f4f3a11b1c4bbd9ffc559c48723f34

Rare Genetic Variants Associated With Myocardial Fibrosis: Multi-Ethnic Study of Atherosclerosis

Autor: Mahsima Shabani, Diptavo Dutta, Bharath Ambale-Venkatesh, Wendy S. Post, Kent D. Taylor, Stephen S. Rich, Colin O. Wu, Naveen L. Pereira, Sanjiv J. Shah, Nilanjan Chatterjee, Jerome I. Rotter, Dan E. Arking, Joao A. C. Lima

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundRare pathogenic variants in cardiomyopathy (CM) genes can predispose to cardiac remodeling or fibrosis. We studied the carrier status for such variants in adults without clinical cardiovascular disease (CVD) in whom cardiac MRI (CMR)-derive

Externí odkaz: https://doaj.org/article/7d9e2463a1694f14ba1215e3dc41f0ab

Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study

Autor: Eugene P. Rhee, Aditya Surapaneni, Zihe Zheng, Linda Zhou, Diptavo Dutta, Dan E. Arking, Jingning Zhang, ThuyVy Duong, Nilanjan Chatterjee, Shengyuan Luo, Pascal Schlosser, Rupal Mehta, Sushrut S. Waikar, Santosh L. Saraf, Tanika N. Kelly, Lee L. Hamm, Panduranga S. Rao, Anna V. Mathew, Chi-yuan Hsu, Afshin Parsa, Ramachandran S. Vasan, Paul L. Kimmel, Clary B. Clish, Josef Coresh, Harold I. Feldman, Morgan E. Grams

Publikováno v: Kidney Int

Metabolomics genome wide association study (GWAS) help outline the genetic contribution to human metabolism. However, studies to date have focused on relatively healthy, population-based samples of White individuals. Here, we conducted a GWAS of 537

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582755de1fd3ae8c4986b9d630944c72
https://doi.org/10.1016/j.kint.2022.01.014

Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Autor: Stella Koutros, Lambertus A. Kiemeney, Parichoy Pal Choudhury, Roger L. Milne, Evangelina Lopez de Maturana, Yuanqing Ye, Vijai Joseph, Oscar Florez-Vargas, Lars Dyrskjøt, Jonine Figueroa, Diptavo Dutta, Graham G. Giles, Michelle A.T. Hildebrandt, Kenneth Offit, Manolis Kogevinas, Elisabete Weiderpass, Marjorie L. McCullough, Neal D. Freedman, Demetrius Albanes, Charles Kooperberg, Victoria K. Cortessis, Margaret R. Karagas, Alison Johnson, Molly R. Schwenn, Dalsu Baris, Helena Furberg, Dean F. Bajorin, Olivier Cussenot, Geraldine Cancel-Tassin, Simone Benhamou, Peter Kraft, Stefano Porru, Angela Carta, Timothy Bishop, Melissa C. Southey, Giuseppe Matullo, Tony Fletcher, Rajiv Kumar, Jack A. Taylor, Philippe Lamy, Frederik Prip, Mark Kalisz, Stephanie J. Weinstein, Jan G. Hengstler, Silvia Selinski, Mark Harland, Mark Teo, Anne E. Kiltie, Adonina Tardón, Consol Serra, Alfredo Carrato, Reina García-Closas, Josep Lloreta, Alan Schned, Petra Lenz, Elio Riboli, Paul Brennan, Anne Tjønneland, Thomas Otto, Daniel Ovsiannikov, Frank Volkert, Sita H. Vermeulen, Katja K. Aben, Tessel E. Galesloot, Constance Turman, Immaculata De Vivo, Edward Giovannucci, David J. Hunter, Chancellor Hohensee, Rebecca Hunt, Alpa V. Patel, Wen-Yi Huang, Gudmar Thorleifsson, Manuela Gago-Dominguez, Pilar Amiano, Klaus Golka, Mariana C. Stern, Wusheng Yan, Jia Liu, Shengchao Alfred Li, Shilpa Katta, Amy Hutchinson, Belynda Hicks, William A. Wheeler, Mark P. Purdue, Katherine A. McGlynn, Cari M. Kitahara, Christopher A. Haiman, Mark H. Greene, Thorunn Rafnar, Nilanjan Chatterjee, Stephen J. Chanock, Xifeng Wu, Francisco X. Real, Debra T. Silverman, Montserrat Garcia-Closas, Kari Stefansson, Ludmila Prokunina-Olsson, Núria Malats, Nathaniel Rothman

Publikováno v: European Urology, 84, 1, pp. 127-137
Koutros, S, Kiemeney, L A, Pal Choudhury, P, Milne, R L, Lopez de Maturana, E, Ye, Y, Joseph, V, Florez-Vargas, O, Dyrskjøt, L, Figueroa, J, Dutta, D, Giles, G G, Hildebrandt, M A T, Offit, K, Kogevinas, M, Weiderpass, E, McCullough, M L, Freedman, N D, Albanes, D, Kooperberg, C, Cortessis, V K, Karagas, M R, Johnson, A, Schwenn, M R, Baris, D, Furberg, H, Bajorin, D F, Cussenot, O, Cancel-Tassin, G, Benhamou, S, Kraft, P, Porru, S, Carta, A, Bishop, T, Southey, M C, Matullo, G, Fletcher, T, Kumar, R, Taylor, J A, Lamy, P, Prip, F, Kalisz, M, Weinstein, S J, Hengstler, J G, Selinski, S, Harland, M, Teo, M, Kiltie, A E, Tardón, A, Serra, C & UROMOL Consortium 2023, ' Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights ', European Urology, vol. 84, no. 1, pp. 127-137 . https://doi.org/10.1016/j.eururo.2023.04.020

Contains fulltext : 293880.pdf (Publisher’s version ) (Closed access) BACKGROUND: Genomic regions identified by genome-wide association studies (GWAS) for bladder cancer risk provide new insights into etiology. OBJECTIVE: To identify new susceptibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c200a167fe41649dcfa38403fe6a2b1
https://repository.ubn.ru.nl/handle/2066/293880