Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Diptadip Dattaroy"'
Autor:
Liu Liu, Kimberley El, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Glucagon, a hormone released from pancreatic α-cells, is critical for maintaining euglycemia and plays a key role in the pathophysiology of diabetes. To stimulate the development of new classes of therapeutic agents targeting glucagon relea
Externí odkaz:
https://doaj.org/article/351c5d2d342f41a0a55bf933e3b5e318
Autor:
Liu Liu, Kimberley EI, Diptadip Dattaroy, Luiz F. Barella, Yinghong Cui, Sarah M. Gray, Carla Guedikian, Min Chen, Lee S. Weinstein, Emily Knuth, Erli Jin, Matthew J. Merrins, Jeffrey Roman, Klaus H. Kaestner, Nicolai Doliba, Jonathan E. Campbell, Jürgen Wess
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/90b54496c01f4db795d6cee6a571c9d1
Autor:
Liu Liu, Diptadip Dattaroy, Katherine F. Simpson, Luiz F. Barella, Yinghong Cui, Yan Xiong, Jian Jin, Gabriele M. König, Evi Kostenis, Jefferey C. Roman, Klaus H. Kaestner, Nicolai M. Doliba, Jürgen Wess
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Glucagon, a hormone released from pancreatic α cells, plays a key role in maintaining euglycemia. New insights into the signaling pathways that control glucagon secretion may stimulate the development of novel therapeutic agents. In this study, we i
Externí odkaz:
https://doaj.org/article/c38dd95266e54296ab7d20f538d7f6e4
Autor:
Firas Alhasson, Ratanesh Kumar Seth, Sutapa Sarkar, Diana A. Kimono, Muayad S. Albadrani, Diptadip Dattaroy, Varun Chandrashekaran, Geoffrey I. Scott, Samir Raychoudhury, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 1-15 (2018)
High circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E
Externí odkaz:
https://doaj.org/article/74b238fabfc549c98d1cd9024c69439c
Autor:
Varun Chandrashekaran, Ratanesh K. Seth, Diptadip Dattaroy, Firas Alhasson, Jacek Ziolenka, James Carson, Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Saurabh Chatterjee
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 8-19 (2017)
Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown. The present study identifies high mobility
Externí odkaz:
https://doaj.org/article/24e8fd36be8c4ea0a6d7358176b07182
Autor:
Firas Alhasson, Suvarthi Das, Ratanesh Seth, Diptadip Dattaroy, Varun Chandrashekaran, Caitlin N Ryan, Luisa S Chan, Traci Testerman, James Burch, Lorne J Hofseth, Ronnie Horner, Mitzi Nagarkatti, Prakash Nagarkatti, Stephen M Lasley, Saurabh Chatterjee
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172914 (2017)
Many of the symptoms of Gulf War Illness (GWI) that include neurological abnormalities, neuroinflammation, chronic fatigue and gastrointestinal disturbances have been traced to Gulf War chemical exposure. Though the association and subsequent evidenc
Externí odkaz:
https://doaj.org/article/7a187cf52903468d946f658d5c67ac39
Autor:
Sahar Pourhoseini, Ratanesh Kumar Seth, Suvarthi Das, Diptadip Dattaroy, Maria B Kadiiska, Guanhua Xie, Gregory A Michelotti, Mitzi Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116780 (2015)
Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinus
Externí odkaz:
https://doaj.org/article/bc6886eb254b42b69ee1d751665f6df6
Autor:
Jian Jin, Liu Liu, Diptadip Dattaroy, Yinghong Cui, Gabriele M. König, Yan Xiong, Evi Kostenis, Luiz Felipe Barella, Jürgen Wess, Jefferey C. Roman, Katherine F. Simpson, Nicolai M. Doliba, Klaus H. Kaestner
Publikováno v:
JCI Insight
Glucagon, a hormone released from pancreatic α cells, plays a key role in maintaining euglycemia. New insights into the signaling pathways that control glucagon secretion may stimulate the development of novel therapeutic agents. In this study, we i
Autor:
James E. Melvin, Diptadip Dattaroy, Jürgen Wess, Mario Rossi, Jennifer Langel, Nicolai M. Doliba, Hongchao Zheng, Taro Mukaibo, Franz M. Matschinsky, Lu Zhu, Daniel H. Appella, Samer Hattar, Jonathan Pham, Amanda Cohen
Publikováno v:
Proceedings of the National Academy of Sciences. 116:18684-18690
Given the global epidemic in type 2 diabetes, novel antidiabetic drugs with increased efficacy and reduced side effects are urgently needed. Previous work has shown that M3 muscarinic acetylcholine (ACh) receptors (M3Rs) expressed by pancreatic β ce
Autor:
Amanda Cohen, Daniel Metzger, Derek B.J. Bone, Jonas R. Knudsen, Thomas E. Jensen, Jürgen Wess, Huiyan Lu, Diptadip Dattaroy, Regina J. Lee, Jaroslawna Meister
Publikováno v:
Diabetes
Skeletal muscle (SKM) insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Because G-protein–coupled receptors (GPCRs) represent excellent drug targets, we hypothesized that activation of specific functional classes of SK