Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome.

Autor: Goran Hamid Mohammad, S W M Olde Damink, Massimo Malago, Dipok Kumar Dhar, Stephen P Pereira

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151635 (2016)

Pancreatic cancer has a 5-year survival rate of less than 4%. Despite advances in diagnostic technology, pancreatic cancer continues to be diagnosed at a late and incurable stage. Accurate biomarkers for early diagnosis and to predict treatment respo

Externí odkaz: https://doaj.org/article/862c7b5dc7cb48daa1f1700da10af990

Acute Cholecystitis and Cholelithiasis Developed after Esophagectomy

Autor: Mitsuo Tachibana, Shoichi Kinugasa, Hiroshi Yoshimura, Dipok Kumar Dhar, Shuhei Ueda, Toshiyuki Fujii, Takeru Nakamoto, Ioannis Kyriazanos, Naofumi Nagasue

Publikováno v: Canadian Journal of Gastroenterology, Vol 17, Iss 3, Pp 175-178 (2003)

BACKGROUND: Although the prevalence of gallstone disease after gastrectomy is reported to be high, its prevalence after esophagectomy is scarcely reported.

Externí odkaz: https://doaj.org/article/d52a24e7eae4407eb3fed03f11610c5e

Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer

Autor: Dipok Kumar Dhar, Steven W.M. Olde Damink, Massimo Malagó, Pilar Acedo, Goran Mohammad, Vessela Vassileva, Stephen P. Pereira

Publikováno v: Cancers, 11(9):1372. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 11, Iss 9, p 1372 (2019)
Cancers
Cancers 11(9), (2019). doi:10.3390/cancers11091372
Volume 11
Issue 9

Reprogrammed glucose metabolism is one of the hallmarks of cancer, and increased expression of key glycolytic enzymes, such as pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA), has been associated with poor prognosis in various malignanci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5638e3710116a9939277f39dd34aa7
https://cris.maastrichtuniversity.nl/en/publications/42d81cce-3271-4d74-b73d-b8f5729e0440

A Novel Approach to Ultrasound-Mediated Tissue Decellularization and Intra-Hepatic Cell Delivery in Rats

Autor: Nader Saffari, Massimo Malagó, Dipok Kumar Dhar, Goran Mohammad, Ki Joo Pahk

Publikováno v: Ultrasound in Medicine & Biology. 42:1958-1967

Liver transplantation is the mainstay of treatment for end stage liver diseases, including metabolic and congenital liver diseases. The number of suitable donor organs is, however, limited, and a whole-liver transplant requires complex surgery. Cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731bf24a3dd70858ed95ebd349cd22b3
https://doi.org/10.1016/j.ultrasmedbio.2016.03.020

The adenosine monophosphate-activated protein kinase-vacuolar adenosine triphosphatase-pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells

Autor: Massimo Pinzani, Andrew J. Hall, Francesco De Chiara, Benoit Viollet, Ana Levi, Giuseppe Mazza, Zhang Zhenzhen, Martina Marrali, Giusi Marrone, Anabel Fernández-Iglesias, Katrin Böttcher, Tu Vinh Luong, Dipok Kumar Dhar, Lisa Longato, Krista Rombouts

Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2018, 68 (3), pp.1140-1153. ⟨10.1002/hep.30029⟩
Hepatology, 2018, 68 (3), pp.1140-1153. ⟨10.1002/hep.30029⟩

Liver fibrosis and cirrhosis are characterized by activation of hepatic stellate cells (HSCs), which is associated with higher intracellular pH (pHi). The vacuolar H+ adenosine‐triphosphatase (v‐ATPase) multisubunit complex is a key regulator of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b52179cb6cb3ff7820ee074806705c
https://www.hal.inserm.fr/inserm-02349906