The Coordination of Local Translation, Membranous Organelle Trafficking, and Synaptic Plasticity in Neurons

Autor: Dipen Rajgor, Theresa M. Welle, Katharine R. Smith

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic prot

Externí odkaz: https://doaj.org/article/2fab1404294045748eb4162d9b564655

The Ins and Outs of miRNA-Mediated Gene Silencing during Neuronal Synaptic Plasticity

Autor: Dipen Rajgor, Jonathan G. Hanley

Publikováno v: Non-Coding RNA, Vol 2, Iss 1, p 1 (2016)

Neuronal connections through specialized junctions, known as synapses, create circuits that underlie brain function. Synaptic plasticity, i.e., structural and functional changes to synapses, occurs in response to neuronal activity and is a critical r

Externí odkaz: https://doaj.org/article/b12ce3438a924a20b5ec0820640f2fcd

Differential regulation of the Rac1 GTPase–activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons

Autor: Katharine R. Smith, Jonathan G. Hanley, Dipen Rajgor

Publikováno v: The Journal of Biological Chemistry
Smith, K, Rajgor, D & Hanley, J 2017, ' Differential regulation of the Rac1 GTPase activating protein (GAP) BCR during oxygen/glucose deprivation in hippocampal and cortical neurons ', Journal of Biological Chemistry, vol. 292, no. 49, pp. 20173–20183 . https://doi.org/10.1074/jbc.M117.796292

Brain ischemia causes oxygen and glucose deprivation (OGD) in neurons, triggering a cascade of events leading to synaptic accumulation of glutamate. Excessive activation of glutamate receptors causes excitotoxicity and delayed cell death in vulnerabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4583b73eda97443500d72b122dbb1e5
http://europepmc.org/articles/PMC5724004

Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation

Autor: Joshua D. Garcia, Dipen Rajgor, Jennifer L. Sanderson, Theresa M. Welle, Mark L. Dell'Acqua, Alicia Purkey, Katharine R. Smith

Publikováno v: Cell Reports. 31:107785

Molecular mechanisms underlying plasticity at brain inhibitory synapses remain poorly characterized. Increased postsynaptic clustering of GABAA receptors (GABAARs) rapidly strengthens inhibition during inhibitory long-term potentiation (iLTP). Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::816c478b260a7f79b866da42e1806eb9
https://doi.org/10.1016/j.celrep.2020.107785

NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity

Autor: Jonathan G. Hanley, Dipen Rajgor, Thomas M. Sanderson, Graham L. Collingridge, Mascia Amici

Publikováno v: Rajgor, D, Sanderson, T, Amici, M, Collingridge, G L & Hanley, J 2018, ' NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity ', EMBO Journal, vol. 37, no. 11, e97943 . https://doi.org/10.15252/embj.201797943
The EMBO Journal

MicroRNAs (miRNAs) repress translation of target mRNAs by associating with Argonaute (Ago) proteins to form the RNA‐induced silencing complex (RISC), underpinning a powerful mechanism for fine‐tuning protein expression. Specific miRNAs are requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a936e7d889ff1c28e384f949fac541c
https://research-information.bris.ac.uk/ws/files/156205604/embj.201797943.full.pdf