Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Dipankar Bhandari"'
Autor:
Annamaria Sgromo, Tobias Raisch, Praveen Bawankar, Dipankar Bhandari, Ying Chen, Duygu Kuzuoğlu-Öztürk, Oliver Weichenrieder, Elisa Izaurralde
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Roquin proteins downregulate target mRNA expression by recruiting effectors such as the CCR4-NOT deadenylase complex. Here the authors provide molecular details of how Roquin proteins recruit the CCR4-NOT complex to repress the expression of its targ
Externí odkaz:
https://doaj.org/article/dd58df3ad8ed437f920ca025930a2428
Autor:
Cátia Igreja, Ying Chen, Lara Wohlbold, Ramona Weber, Dipankar Bhandari, Eugene Valkov, Chung Te Chang, Yevgen Levdansky, Sowndarya Muthukumar, Elisa Izaurralde
Publikováno v:
Nucleic Acids Research
XRN1 is the major cytoplasmic exoribonuclease in eukaryotes, which degrades deadenylated and decapped mRNAs in the last step of the 5′–3′ mRNA decay pathway. Metazoan XRN1 interacts with decapping factors coupling the final stages of decay. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1c112ae6d5d7bf8d45dfca95f2570d
http://europepmc.org/articles/PMC6753473
http://europepmc.org/articles/PMC6753473
Autor:
Tobias Raisch, Elisa Izaurralde, Oliver Weichenrieder, Cátia Igreja, Annamaria Sgromo, Dipankar Bhandari, Csilla Keskeny
Publikováno v:
Genes & Development. 33:236-252
The multisubunit CCR4–NOT mRNA deadenylase complex plays important roles in the posttranscriptional regulation of gene expression. The NOT4 E3 ubiquitin ligase is a stable component of the CCR4–NOT complex in yeast but does not copurify with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0118dad42a77ae2994369297bcfc1ca
https://doi.org/10.1101/gad.320952.118
https://doi.org/10.1101/gad.320952.118
Autor:
Kevin Sabath, Tobias Raisch, Sigrun Helms, Oliver Weichenrieder, Eugene Valkov, Elisa Izaurralde, Dipankar Bhandari
Publikováno v:
The EMBO Journal
Nanos proteins repress the expression of target mRNAs by recruiting effector complexes through non‐conserved N‐terminal regions. In vertebrates, Nanos proteins interact with the NOT1 subunit of the CCR4–NOT effector complex through a NOT1 inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7567338f0d77b235e8624ba3bd4b0e23
http://europepmc.org/articles/PMC5207322
http://europepmc.org/articles/PMC5207322
Publikováno v:
Parasitology Research. 113:2941-2949
In nearly complete absence of transcriptional regulation, messenger RNA (mRNA) turnover mediated through specific cis-elements plays a predominant role in the control of differential gene expression for the disease causing trypanosomatid parasites. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6e21cd585eb62ecaf7c6032e693dfc
https://doi.org/10.1007/s00436-014-3956-z
https://doi.org/10.1007/s00436-014-3956-z
Publikováno v:
Genes & Development. 28:888-901
The RNA-binding proteins of the Nanos family play an essential role in germ cell development and survival in a wide range of metazoan species. They function by suppressing the expression of target mRNAs through the recruitment of effector complexes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb63763e1a8fb11d80895905cc7c2fe
https://doi.org/10.1101/gad.237289.113
https://doi.org/10.1101/gad.237289.113
Autor:
Dipankar Bhandari, Ramona Weber, Tobias Raisch, Cátia Igreja, Maria Fauser, Aoife Hanet, Duygu Kuzuoğlu-Öztürk, Vincenzo Ruscica, Chung Te Chang, Felix Räsch, Lara Wohlbold
Publikováno v:
Life Science Alliance
The putative UPF1-like SF1 helicase HELZ directly interacts with the CCR4–NOT deadenylase complex to induce translational repression and 5′-to-3′ decay of bound mRNAs.
Eukaryotic superfamily (SF) 1 helicases have been implicated in various
Eukaryotic superfamily (SF) 1 helicases have been implicated in various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7156357f9f72d6482f003742d02cead6
https://doi.org/10.26508/lsa.201900405
https://doi.org/10.26508/lsa.201900405
Autor:
Annamaria Sgromo, Ying Chen, Elisa Izaurralde, Tobias Raisch, Praveen Bawankar, Oliver Weichenrieder, Dipankar Bhandari, Duygu Kuzuoğlu-Öztürk
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Human (Hs) Roquin1 and Roquin2 are RNA-binding proteins that promote mRNA target degradation through the recruitment of the CCR4-NOT deadenylase complex and are implicated in the prevention of autoimmunity. Roquin1 recruits CCR4-NOT via a C-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6752cee835a1ad22e18de8276ac79da
https://pubmed.ncbi.nlm.nih.gov/28165457
https://pubmed.ncbi.nlm.nih.gov/28165457
Autor:
Mary Christie, Daniel Peter, Dipankar Bhandari, Stefanie Jonas, Belinda Loh, Elisa Izaurralde, Eric Huntzinger, Oliver Weichenrieder
Publikováno v:
Nature structuralmolecular biology. 21(7)
Structural analyses reveal the asymmetric assembly of Neurospora crassa PAN2–PAN3 complex and, along with functional work on the proteins from different species, indicate an essential role for PAN3 in coordinating PAN2-mediated deadenylation with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e54deec43982237ba78994517763b12
https://pubmed.ncbi.nlm.nih.gov/24880343
https://pubmed.ncbi.nlm.nih.gov/24880343
Autor:
Partha Saha, Dipankar Bhandari
Publikováno v:
FEMS microbiology letters. 273(2)
The lack of transcriptional regulation in trypanosomatids suggests the presence of distinct posttranscriptional mechanisms to control differential gene expression. In fact, the stability of S-phase specific mRNAs in these parasites is determined prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dbf01cb96e267449c7fc3ff665540d
https://pubmed.ncbi.nlm.nih.gov/17559572
https://pubmed.ncbi.nlm.nih.gov/17559572