Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Dipanjan Chowdhury"'
Autor:
Miguel Angel Pardo-Cea, Xavier Farré, Anna Esteve, Joanna Palade, Roderic Espín, Francesca Mateo, Eric Alsop, Marc Alorda, Natalia Blay, Alexandra Baiges, Arzoo Shabbir, Francesc Comellas, Antonio Gómez, Montserrat Arnan, Alex Teulé, Monica Salinas, Laura Berrocal, Joan Brunet, Paula Rofes, Conxi Lázaro, Miquel Conesa, Juan Jose Rojas, Lars Velten, Wojciech Fendler, Urszula Smyczynska, Dipanjan Chowdhury, Yong Zeng, Housheng Hansen He, Rong Li, Kendall Van Keuren-Jensen, Rafael de Cid, Miquel Angel Pujana
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-22 (2024)
Abstract Background The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk r
Externí odkaz:
https://doaj.org/article/5f8c5c339bf345519940b8098cf83a6d
Autor:
Eva Tsaousidou, Jędrzej Chrzanowski, Pascal Drané, Grace Y. Lee, Nadine Bahour, Zeqiu Branden Wang, Shijun Deng, Zhe Cao, Kaimeng Huang, Yizhou He, Mateusz Kaminski, Dominika Michalek, Ekin Güney, Kalindi Parmar, Wojciech Fendler, Dipanjan Chowdhury, Gökhan S. Hotamışlıgil
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114337- (2024)
Summary: It is unclear whether metabolic health corresponds to reduced oncogenesis or vice versa. We study Tudor-interacting repair regulator (TIRR), an inhibitor of p53 binding protein 1 (53BP1)-mediated p53 activation, and the physiological consequ
Externí odkaz:
https://doaj.org/article/c830c19e952a4a9ebd6b580b85dca154
Autor:
Gaofeng Cui, Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James R. Thompson, David J. Schuller, Alexandre Detappe, Michael T. Perfetti, Lindsey I. James, Stephen V. Frye, Dipanjan Chowdhury, Georges Mer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair. Using a series of small molecule antagonists, we demonstrate a conformati
Externí odkaz:
https://doaj.org/article/0f5b7e97b6324cda80e7ab7f47fa3f98
Autor:
Kevin Elias, Urszula Smyczynska, Konrad Stawiski, Zuzanna Nowicka, James Webber, Jakub Kaplan, Charles Landen, Jan Lubinski, Asima Mukhopadhyay, Dona Chakraborty, Denise C. Connolly, Heather Symecko, Susan M. Domchek, Judy E. Garber, Panagiotis Konstantinopoulos, Wojciech Fendler, Dipanjan Chowdhury
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Identifying germline BRCA1/2 mutation carriers is vital for reducing their risk of breast and ovarian cancer. To derive a serum miRNA-based diagnostic test we used samples from 653 healthy women from six international cohorts, including 350
Externí odkaz:
https://doaj.org/article/a02df781daaa4b0c894cbc2fcadb377a
Autor:
Utsarga Adhikary, Joao A. Paulo, Marina Godes, Shrabasti Roychoudhury, Michelle S. Prew, Yael Ben-Nun, Ellen W. Yu, Amit Budhraja, Joseph T. Opferman, Dipanjan Chowdhury, Steven P. Gygi, Loren D. Walensky
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113176- (2023)
Summary: MCL-1 is a high-priority target due to its dominant role in the pathogenesis and chemoresistance of cancer, yet clinical trials of MCL-1 inhibitors are revealing toxic side effects. MCL-1 biology is complex, extending beyond apoptotic regula
Externí odkaz:
https://doaj.org/article/8e604e1e9c314f39806640bf06f448b9
Autor:
Panagiotis A. Konstantinopoulos, Alexandre André B. A. da Costa, Doga Gulhan, Elizabeth K. Lee, Su-Chun Cheng, Andrea E. Wahner Hendrickson, Bose Kochupurakkal, David L. Kolin, Elise C. Kohn, Joyce F. Liu, Elizabeth H. Stover, Jennifer Curtis, Nabihah Tayob, Madeline Polak, Dipanjan Chowdhury, Ursula A. Matulonis, Anniina Färkkilä, Alan D. D’Andrea, Geoffrey I. Shapiro
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
A randomized phase 2 study recently showed that the addition of ATR inhibitor berzosertib to gemcitabine improved PFS compared to gemcitabine alone in patients with ovarian cancer. In this preplanned exploratory study, the authors demonstrate that a
Externí odkaz:
https://doaj.org/article/47ca4fa1fe9849e2a78a9dcd5d68a796
Autor:
Allison Gockley, Konrad Pagacz, Stephen Fiascone, Konrad Stawiski, Nicole Holub, Kathleen Hasselblatt, Daniel W. Cramer, Wojciech Fendler, Dipanjan Chowdhury, Kevin M. Elias
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Neural network analyses of circulating miRNAs have shown potential as non-invasive screening tests for ovarian cancer. A clinically useful test would detect occult disease when complete cytoreduction is most feasible. Here we used murine xenografts t
Externí odkaz:
https://doaj.org/article/9d8861da54ff467785e0f139b9f5edb2
Autor:
Anniina Färkkilä, Doga C. Gulhan, Julia Casado, Connor A. Jacobson, Huy Nguyen, Bose Kochupurakkal, Zoltan Maliga, Clarence Yapp, Yu-An Chen, Denis Schapiro, Yinghui Zhou, Julie R. Graham, Bruce J. Dezube, Pamela Munster, Sandro Santagata, Elizabeth Garcia, Scott Rodig, Ana Lako, Dipanjan Chowdhury, Geoffrey I. Shapiro, Ursula A. Matulonis, Peter J. Park, Sampsa Hautaniemi, Peter K. Sorger, Elizabeth M. Swisher, Alan D. D’Andrea, Panagiotis A. Konstantinopoulos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
A Phase I/II trial previously revealed variable anti-tumor efficacy of the PARP inhibitor niraparib in combination with the PD-1 inhibitor pembrolizumab in platinum-resistant ovarian cancer patients. Here, the authors perform an integrated genomic an
Externí odkaz:
https://doaj.org/article/bd4459e944254dc4845c521cfcab9cf4
Autor:
Konrad Pagacz, Przemyslaw Kucharski, Urszula Smyczynska, Szymon Grabia, Dipanjan Chowdhury, Wojciech Fendler
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background The consensus on how to choose a reference gene for serum or plasma miRNA expression qPCR studies has not been reached and none of the potential candidates have yet been convincingly validated. We proposed a new in silico approach
Externí odkaz:
https://doaj.org/article/b74f48ca291749519a0d5573c5ed5a34
Autor:
Xiao-Feng Zheng, Sanket S. Acharya, Katherine N. Choe, Kumar Nikhil, Guillaume Adelmant, Shakti Ranjan Satapathy, Samanta Sharma, Keith Viccaro, Sandeep Rana, Amarnath Natarajan, Peter Sicinski, Jarrod A. Marto, Kavita Shah, Dipanjan Chowdhury
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.
Externí odkaz:
https://doaj.org/article/2c564c99951247baadb473f227a8cb95