Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dipam Patel"'
Autor:
Krishnarup Ghoshdastidar, Hoshang Patel, Hitesh Bhayani, Ankit Patel, Kinjal Thakkar, Dinesh Patel, Manoranjan Sharma, Jaideep Singh, Jogeswar Mohapatra, Abhijit Chatterjee, Dipam Patel, Rajesh Bahekar, Rajiv Sharma, Lakshmikant Gupta, Nirmal Patel, Poonam Giri, Nuggehally R. Srinivas, Mukul Jain, Debdutta Bandyopadhyay, Pankaj R. Patel, Ranjit C. Desai
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract Bruton's tyrosine kinase (BTK) plays a central and pivotal role in controlling the pathways involved in the pathobiology of cancer, rheumatoid arthritis (RA), and other autoimmune disorders. ZYBT1 is a potent, irreversible, specific BTK inhi
Externí odkaz:
https://doaj.org/article/426ccabb23744fc0aceb0a7d29b505f0
Autor:
Darshan Joshi, Rajesh Bahekar, Shubhangi Soman, Pradip Jadav, Dipam Patel, Amitgiri Goswami, Jignesh Pethani, Jeevan Kumar, Jitendra Patel, Rajesh Sundar, Poonamgiri Goswami, Krishnarup Goshdastidar, Hoshang Patel, Ankit Patel, Debdutta Bandyopadhyay, Abhijit Chattarjee, Manoranjan Sharma, Mukul Jain, Ranjit Desai
Publikováno v:
Bioorganic chemistry. 130
To discover the best-in-class Bruton's Tyrosine Kinase (BTK) inhibitors, for th treatment of autoimmune disorders like cancer (B-Cell Lymphoma (BCL)) and rheumatoid arthritis (RA), in the present investigation, novel structural optimizations were car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4f6b580e492454dbe243bc5a720bf4
https://pubmed.ncbi.nlm.nih.gov/36403335
https://pubmed.ncbi.nlm.nih.gov/36403335
Autor:
Krishnarup Ghoshdastidar, Jeevan Kumar, Jogeswar Mahapatra, Ranjit C. Desai, Dipam Patel, Debdutta Bandyopadhyay, S. Sachchidanand, Purvi Vyas, Rajesh Bahekar, Radhika Funde, Abhijit Chatterjee, Poonam Giri, Shubhangi S. Soman, Bhushan N. Dave, Rajendra Chopade
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1313-1319
PI3Kδ is implicated in various inflammatory and autoimmune diseases. For the effective treatment of chronic immunological disorders such as rheumatoid arthritis, it is essential to develop isoform selective PI3Kδ inhibitors. Structure guided optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de12126b0618081b11549b208238c51f
https://doi.org/10.1016/j.bmcl.2019.04.007
https://doi.org/10.1016/j.bmcl.2019.04.007
Autor:
Dinesh Patel, Dipam Patel, Pankaj R. Patel, Jogeswar Mohapatra, Hoshang Patel, Krishnarup Ghoshdastidar, Abhijit Chatterjee, Rajiv P. Sharma, Mukul R. Jain, Jaideep Singh, Manoranjan Sharma, Poonam Giri, Kinjal Thakkar, Debdutta Bandyopadhyay, Rajesh Bahekar, Hitesh Bhayani, Ranjit C. Desai, Ankit Patel, Lakshmikant Gupta, Nuggehally R. Srinivas, Nirmal Patel
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Bruton's tyrosine kinase (BTK) plays a central and pivotal role in controlling the pathways involved in the pathobiology of cancer, rheumatoid arthritis (RA), and other autoimmune disorders. ZYBT1 is a potent, irreversible, specific BTK inhibitor tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4e4ffa841ea0712306327b9f3c7fca
https://doaj.org/article/426ccabb23744fc0aceb0a7d29b505f0
https://doaj.org/article/426ccabb23744fc0aceb0a7d29b505f0
Autor:
Dheerendra Pandey, Rajesh Bahekar, Brijesh Sutariya, Dipam Patel, Ramchandra Ranvir, Vishal Patel, Hiren Patel, Amit Joharapurkar, Samadhan Kshirsagar, Mukul R. Jain, Maulik Patel, Shekhar Kadam
Publikováno v:
Cardiovascular & Hematological Agents in Medicinal Chemistry. 16:35-43
Background Obesity, diabetes and dyslipidemica are the key pathogenic stimulus that enhances progression of Non-Alcoholic Fatty Liver Disease (NAFLD). Coagonist of Glucagon Like- Peptide-1 (GLP-1) Receptor (GLP-1R) and Glucagon Receptor (GCGR) are be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfba0fb49d05486059716daf11e390c8
https://doi.org/10.2174/1871525716666180118152158
https://doi.org/10.2174/1871525716666180118152158
Autor:
Dipam Patel, Hiren M. Patel, Shekhar Kadam, Brijesh Sutariya, Mukul R. Jain, Rajesh Bahekar, Amit Joharapurkar, Vishal Patel, Samadhan Kshirsagar, Dheerendra Pandey, Maulik Patel, Ramchandra Ranvir
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:587-596
Nonalcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. Coagonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) are under clinical investigation for the treatment of obesity and type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdd0c75f9c2082a3aac32f5a57dcdfb
https://doi.org/10.1139/cjpp-2017-0683
https://doi.org/10.1139/cjpp-2017-0683
Autor:
Dipam Patel, Vishal Patel, Hiren M. Patel, Dheerendra Pandey, Rajesh Bahekar, Brijesh Sutariya, Amit Joharapurkar, Mukul R. Jain, Samadhan Kshirsagar, Maulik Patel
Publikováno v:
Biomedicine & Pharmacotherapy. 98:364-371
Coagonists of Glucagon-like peptide-1 (GLP-1) and glucagon receptors are under clinical investigation for treatment of obesity associated with diabetes. In addition to their role in glucose homeostasis, GLP-1 and glucagon modulate lipid metabolism. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b4e57b4c090a40ffebce2a37c6a6e9
https://doi.org/10.1016/j.biopha.2017.12.068
https://doi.org/10.1016/j.biopha.2017.12.068
Autor:
Dipam Patel, Ranjit C. Desai, Darshan A. Joshi, Amitgiri D. Goswami, Sameer Agarwal, Jignesh P. Pethani, Pradip Jadav, Rajesh Bahekar, Hardik A. Shah, Bhushan N. Dave
Publikováno v:
Organic Process Research & Development. 21:266-272
Hexahydrocyclopentapyrrolone derivatives constitute an important class of bicycles, and it represents an essential pharmacophore for diversified pharmacological activities. A highly efficient process for the synthesis of tert-butyl(3aR,6aS)-5-oxohexa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f2938d965f14bb3a70a126017ae12db
https://doi.org/10.1021/acs.oprd.6b00399
https://doi.org/10.1021/acs.oprd.6b00399
Autor:
Reza Monfaredi, Kevin Cleary, Chima O. Oluigbo, Dipam Patel, Likhita Madiraju, Ajeet Wankhede
Publikováno v:
Medical Imaging: Image-Guided Procedures
In brain tumor ablation procedures, imaging for path planning and tumor ablation are performed in two different sessions. Using pre-operative MR images, the neurosurgeon determines an optimal ablation path to maximize tumor ablation in a single path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a35cf573ec0ffa7e166b7ce3acd0230e
https://doi.org/10.1117/12.2512352
https://doi.org/10.1117/12.2512352
Autor:
Debdutta Bandyopadhyay, Jigar Desai, Abhijit Chatterjee, Hoshang Patel, S. Sachchidanand, Rajesh Bahekar, Jeevan Kumar, Dipam Patel, Krishnarup Ghoshdastidar, Anil Argade, Harilal Patel, Archana Gite, Bhaumin Patel, Sanjay Gite, Jogeswar Mahapatra, Nandini Panchal, Rajesh Sundar, Ranjit C. Desai, Shubhangi S. Soman
Publikováno v:
Bioorganic Chemistry. 99:103851
Selective inhibition of janus kinase (JAK) has been identified as an important strategy for the treatment of autoimmune disorders. Optimization at the C2 and C4-positions of pyrimidine ring of Cerdulatinib led to the discovery of a potent and orally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f57c25ee9d80ecff1fec355cd350348
https://doi.org/10.1016/j.bioorg.2020.103851
https://doi.org/10.1016/j.bioorg.2020.103851